Cardiovascular

Found 10 technologies within Cardiovascular RSS ATOM

PON3 and Uses Thereof

1855d1 – The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability to alter PON3 associated activities, methods for generating antibodies useful in the detection of PON3, and... Read More

An Ostial Stenting System

3602 – While use of stents has revolutionized the field of vascular interventions, significant challenges remain. For example, in non-coronary beds the ostial location is particularly prone to develop atherosclerosis and is the commonest site of disease in renal vessels. The goal of treatment in these lesions is to adequately cover the vessel ostium without leaving excess stent protruding into... Read More

Local Pulsewave Velocity Measurement Using a Linear Array

3529 – This technology uses standard ultrasound imaging equipment to measure arterial pulse wave velocity and intramural strain locally and non-invasively. Measuring these two parameters simultaneously and locally enables early detection of local changes in arterial compliance. Reduced arterial compliance indicates the presence of various diseases including caradiovascular diseases, diabetes,... Read More

Inhibitors of RGS Proteins

2157 – RGS proteins represent a novel family of proteins that regulate the activity of G protein and G protein-coupled receptors. There are over twenty members of this protein family, and it continues to grow as new members are discovered. The primary action of RGS proteins is to speed the deactivation of G proteins thus inhibiting G protein signaling. G protein-coupled receptors are involved in... Read More

Functionally Tailored Composite Devices for Tissue Regeneration and Bioactive Factor Delivery

2142 – Selective laser sintering is a solid freeform fabrication method which is capable of fabricating complexly shaped objects directly from computer models. The method is commercially available, and builds objects in a layer by layer manner, using laser to selectively fuse powder particles. While conventional selective laser sintering technology allows a user to create variation in material... Read More

Discrimination of one to one Tachycardias Using the Variability of Atrioventricular and Ventriculoatrial Intervals

1999 – Cardiac rhythm management devices known as implantable cardioverter/defibrillators (ICDs) are designed to treat ventricular tachyarrhythmias by delivering an electrical shock pulse to the heart. Cardioversion and/or defibrillation can be used to terminate most tachyarrhythmias, including VT and VF. The electric shock terminates the tachyarrhythmia by depolarizing all of the myocardium... Read More

Compositions and Methods Useful in Prophylaxis and Treatment Conditions Related to Oxidative Damage, Endotoxemia and Chemical Toxicity

1855 – Endotoxic shock is a condition, provoked by the release of lipopolysaccharide (LPS) from the outer membrane of most gram negative bacteria (e.g., Escherichia coli; Salmonella tymphimurium). One example of a condition involving Endotoxic shock is sepsis. Sepsis is a systemic reaction characterized by arterial hypotension, metabolic acidosis, decreased systemic vascular resistance,... Read More

Technique for Making Angle-Independent Ultrasound Volume Flow Measurements

1710 – Volume flow measurements have always been the most desired ultrasound flow measurement. Unfortunately, such measreuments have been difficult to obtain or the accuray has been limited, and because of this, volume flow measurements are almost never used. The preferred embodiment is useful in an ultrasound system for measuring the volume of fluid flow within a region of interest. In... Read More

Fractional Moving Blood Volume Estimation with Power Doppler Ultrasound

1216 – In the diagnosis of various medical conditions, it is often useful to examine soft tissues and/or blood flow within the body to show structural details of organs and blood vessels in these organs. Multiple studies have demonstrated increased vascularity (blood flow) in many tumors relative to that of normal tissue, and multiple attempts have been made to depict these differences in... Read More

Melanocortin-3, Melanocortin-4, and Melanocortin-5 Receptors

0853 – Melanocortins, products of pro-opiomelanocortin (POMC) post-translational processing, are known to have a broad array of physiological actions. Nakanishi, S. et al., Nature 278:423-427 (1979). Aside from their well known effects on adrenal cortical functions (adrenocorticotropic hormone, ACTH) and on melanocytes (melanocyte stimulating hormone, MSH), melanocortins have been shown to... Read More