Office of Technology Transfer – University of Michigan
51-95 of 95 technologies within Clinical Applications RSS ATOM

Identification of the Gene (NPHP4) Causing Nephronophthisis Type 4 and Retinis Pigmentosa

2417 – Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, constitutes the most frequent genetic cause for end-stage renal disease (ESRD) in children and young adults. NPHP is a progressive hereditary kidney disease marked by anemia, polyuria, renal loss of sodium, progressing to chronic renal failure, tubular atrophy, interstitial fibrosis, glomerular sclerosis, and medullary... Read More

A Method and Apparatus for Alignment of a Sequence of High Dimensional Data

3043 – Image registration transforms different sets of data into a single coordinate system and is thus critical for comparison and integration of data obtained from different measurements. This technique is useful in the medical imaging field as well as in other monitoring, observation and tracking applications. Image registration is complex especially when the images to be correlated exhibit... Read More

Galphai2 RGS-insensitive Mouse

2991 – Regulators of G-protein signaling (RGS) proteins are important components of signal transduction pathways initiated through G-protein-coupled receptors (GPCRs). The RGS proteins have been proposed as novel drug targets since targeting GPCRs directly is the basis for the development of many therapeutics. Furthermore, evidence is mounting that RGS proteins may play a role in disease states... Read More

Schizophrenia Gene #1 - Two Mutations

3076 – Schizophrenia affects ~ 1% of Americans. Diagnosis of schizophrenia and other neuropsychiatric disorders currently relies on behavorial symptoms, such as massive disruption of thinking, mood and overall behavior. Researchers at the University of Michigan have identified markers for neuropsychiatric disorders. In particular, they have studied genetically susceptible regions for... Read More

3D Bioengineered Internal Anal Sphincter(IAS)

2957 – Fecal incontinence affects people of all ages and social backgrounds and can have devastating psychological and economic consequences. This disorder largely attributed to decreased mechanical efficiency of the internal anal sphincter (IAS), yet little is known about the pathophysiological mechanisms responsible for the malfunction of sphincteric smooth muscle at the cellular level. Two... Read More

Isolation of Stem Cells

2939 – Cancer of the oral cavity accounts for approximately 30% of cancers of head and the neck region. When the cancer is treated with surgical intervention, reconstruction of the oral cavity is often required to maintain function and appearance. In these cases, mucosal grafts are used to help with wound closure. One of the clinical limitations for this procedure is the shortage of oral mucosa.... Read More

Reinstatement of Force Generation in 3D Bioengineered Internal Anal Sphincter of Aged Cells

2956 – Fecal incontinence affects approximately 5.5 million Americans, although actual number of people affected may be higher, due to low report rate. Prevalence of fecal incontinence varies by report with a range of 6-15% of women affected and 6-10% of men affected, with the incidence increasing with age. As there are various causes of fecal incontinence including constipation, loss of rectum... Read More

Nucleic Acids and Polypeptides Involved in the Production of Cryptophycin

2863 – Cryptophycins are a novel chemical compounds characterized by their cyclic structure from which their activity is derived. These compounds are isolated from blue-green algae and have been discovered to have potent cytotoxic activity selectively against tumors. In order to explore the possibility of this compound for anti-cancer applications, more efficient synthesis methods for this... Read More

A New Approach for Designing Biodegradable/Bioresorbable Tissue Augmentation/ Reconstruction Devices

2753 – Biomaterials have been widely explored for tissue engineering applications to restore, maintain, or improve tissue function. In particular, biodegradable materials are often used as an initial scaffolding to promote the ingrowth of cells from the surrounding microenvironment and their integration into the implant, with the eventual goal of the biomaterial being replaced by the regenerated... Read More

The Purification of Hematopoietic Stem Cells

2693 – Hematopoietic stem cells (HSCs) are the precursor cells for a variety of blood cells. Because of their self-renewal properties, these cells have been used in transplantation to treat patients with cancers and other disorders related to the blood and immune system. In recent studies, these cells have been implicated for their potential to become cell types other than the blood cells,... Read More

Disturbance in the Neuropathy Target Esterase Pathway Causes Degenerative Neurologic Disease

2611 – Motor neuron disorders include amyotrophic lateral sclerosis, autosomal recessive spastic paraplegia, hereditary spastic paraplegia, primary lateral sclerosis, progressive pseudobulbar palsy, progressive muscular atrophy, progressive bulbar palsy, and postpolio syndrome. Symptoms characteristic for a specific type of motor neuron disorder vary according to the part of the nervous system... Read More

Protein Microarray Analysis Uncovers a Tumor Antigen that Induces a Humoral Immune Response in Colon Cancer

2555 – In the United States, colorectal cancer is the second leading cause of all cancer deaths. If the cancer is found and treated early before it spreads to lymph nodes or other organs, the survival rate is higher. However, less than 40% of colon cancers are discovered at an early stage. Colon cancer is diagnosed by fecal occult blood test, digital rectal examination, barium enema, or... Read More

Delivery System for Treatment of Brain (or other organs) Diseases/Disorders

2496 – One of the challenges in the administration of anticancer therapeutics is the targeted delivery of the therapeutic to the tumor cells in a specific and exclusive manner. As most anticancer agents strongly interfere with replication and other cellular functions, and are often cytotoxic, nonspecific delivery of these agents to noncancerous cells leads to serious toxic side effects. In... Read More

A Novel Gene and its Protein Product that when mutated Causes Myoclonus, Ataxia and Dystonia Syndromes, and Cayman Ataxia

2463 – Ataxia is a clinical sign of lack of muscle coordination, affecting a variety of voluntary movements such as walking, speech, and swallowing. It may also signify a group of degenerative diseases of the nervous system, which may be of sporadic or hereditary nature. Hereditary ataxia is a group of rare genetic neuromuscular disorders. It is often caused by a gene defect that produces... Read More

ErbB-2 Selective Small Molecule Kinase Inhibitors

2396 – Cancer is one of the leading causes of death, second only to heart disease in both men and women. Breast cancer is the most common tumor in women, representing 32% of all new cancer cases and causing 18% of cancer-related deaths of women in the US. One promising avenue for the development of cancer treatments is based on blocking abnormal cell signaling pathways associated with cancers.... Read More

Anti-cancer Screening Test for Inhibitors of HIP1 Function and Specific Inhibitors of HIP1 Function

2392 – Existing cancer screening tests are often invasive, expensive, and lack strong diagnostic utility. For example, prostate cancer is typically diagnosed with a digital rectal exam and/or prostate specific antigen (PSA) screening, which has limited sensitivity and specificity. Thus, development of additional serum and tissue cancer biomarkers is needed to supplement current screening... Read More

Microarray Analysis of Gene Expression in the Aging Human Retina

2247 – Aging is a universal event in all eukaryotes. In humans, it is associated with progressive and perhaps irreversible impairment of physiological functions, including vision. Age related macular degeneration (AMD) is a major cause of untreatable vision loss in the elderly. The etiology of this disease is dependent upon complex interactions between genetic and environmental risk factors; the... Read More

Inhibitors of RGS Proteins

2157 – RGS proteins represent a novel family of proteins that regulate the activity of G protein and G protein-coupled receptors. There are over twenty members of this protein family, and it continues to grow as new members are discovered. The primary action of RGS proteins is to speed the deactivation of G proteins thus inhibiting G protein signaling. G protein-coupled receptors are involved in... Read More

Porous Materials with High Surface Area

2150 – Membranes have been typically used for filtration, reverse osmosis (hyperfiltration), dialysis, pervaporation, and gas separation applications. A solid membrane can be made of synthetic polymers, natural macromolecules, inorganic compounds, ceramic or metallic materials, and are generally fabricated through sintering, stretching, extrusion, phase inversion and etching, or casting. Porous... Read More

Functionally Tailored Composite Devices for Tissue Regeneration and Bioactive Factor Delivery

2142 – Selective laser sintering is a solid freeform fabrication method which is capable of fabricating complexly shaped objects directly from computer models. The method is commercially available, and builds objects in a layer by layer manner, using laser to selectively fuse powder particles. While conventional selective laser sintering technology allows a user to create variation in material... Read More

Molecular Cloning of Orphanin FQ Receptor Gene and Differential Tissue Expression of Splice Variants

2060 – Functional gastrointestinal (GI) and motility disorders affect millions of people of all ages, but presently few treatments are able to restore function. More than 50% of patients undergoing abdominal surgery suffer from post-operative ileus, which currently has no effective treatment. The investigators have demonstrated that Orphanin FQ (OFQ), a neruropeptide, in gastrointestinal... Read More

ExVivo Produced Oral Mucosa Equivalent: A Tissue Engineered Human Oral Mucosa

2045 – Tissue engineering and regenerative medicine has created considerable interest in the clinical application of stem cells to both regenerate body tissues and to deliver genetic material. As an example, production of a specific gene-transduced oral mucosal graft that for reconstruction of major oral defects would be an asset to reconstructive surgery and/or gene therapy. Primary human... Read More

Microtubular Materials and Material/Cell Constructs

1992 – Tissue engineering aims at creating biological alternatives to harvested tissues and organs for transplantation. Scaffolding plays a crucial role in the 3-dimensional neo tissue formation. Synthetic biodegradable polymers are attractive candidates for scaffolding fabrication because they do not carry the risk of pathogen transmission and immuno-rejection, and because they degrade and... Read More

Polyclonal Antibodies to Eotaxin

2022 – Polyclonal Antibodies to Eotaxin

A Specific Antibody for RhoC That Can be Used for Molecular Diagnostics of Human Specimens

2013 – Despite increased awareness of breast cancer and its prevalence, predicting patient outcome is remains difficult. Although the likelihood of metastasis is thought to be linked to the aggressiveness, growth, and size of the primary neoplasm, this is not always the case. There are many small breast cancers with a highly aggressive behavior and discouraging outcome that remain undertreated... Read More

Discrimination of one to one Tachycardias Using the Variability of Atrioventricular and Ventriculoatrial Intervals

1999 – Cardiac rhythm management devices known as implantable cardioverter/defibrillators (ICDs) are designed to treat ventricular tachyarrhythmias by delivering an electrical shock pulse to the heart. Cardioversion and/or defibrillation can be used to terminate most tachyarrhythmias, including VT and VF. The electric shock terminates the tachyarrhythmia by depolarizing all of the myocardium... Read More

UVA (360-400) and UVB (300-325) Specific Sunscreens

1927 – Sun exposure may result in skin photodamage, primarily due to irradiation by ultraviolet A and B rays (UVA and UVB, respectively). Presently, ranges of UV wavelengths thought to be damaging are considered to be 280-320 nm and 320-360 nm for UVB and UVA, respectively. Compounds or mixtures of compounds that absorb UVA and UVB radiation of these wavelengths are used as sunscreens to prevent... Read More

Surgical Knife

1907 – Anterior lens capsule surgery can often be a difficult procedure with existing surgical instruments due to the requirement to create small tears upon the fragile anterior lens capsule for cataract removal. A University of Michigan clinical ophthalmologist has designed and created a working prototype of a surgical blade for incising the intraocular tissue, such as the anterior... Read More

Inhibition of HIV Replication by Blocking IL-8 , GRO-alpha, and /or CXCR2 Function

1891 – Medical therapy for infection with the human immunodeficiency virus type 1 (HIV-1) has improved over the last several years. However, many patients still fail to respond to the available pharmacologic agents, due to drug resistance and other factors. In addition, the antivirals currently available are often not well tolerated by patients. The currently available drugs for treating HIV-1... Read More

Transgenic Mouse Model for Basal Cell Carcinoma

1828 – Basal cell carcinoma (BCC) is the most prevalent form of skin cancer. Annually, approximately 75% of the 1,000,000 new cases of skin cancer diagnosed in the United States are basal cell carcinomas. A major hurdle in the development of new treatments has been the lack of an adequate BCC mouse model that will help scientists understand the genetics and pathobiology of this common disease,... Read More

Positron Emitting Internal Marker for Identification of Tissues by PET Scanning

1806 – Medical diagnostic imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often rely on targeting aids or landmarking devices, which help identify anatomical locations of visualized areas. One of the most common methods used to date is the radiopharmaceutically-assisted technique. This method depends on cellular uptake of suitable imaging... Read More

Compositions and Methods Useful in Prophylaxis and Treatment Conditions Related to Oxidative Damage, Endotoxemia and Chemical Toxicity

1855 – Endotoxic shock is a condition, provoked by the release of lipopolysaccharide (LPS) from the outer membrane of most gram negative bacteria (e.g., Escherichia coli; Salmonella tymphimurium). One example of a condition involving Endotoxic shock is sepsis. Sepsis is a systemic reaction characterized by arterial hypotension, metabolic acidosis, decreased systemic vascular resistance,... Read More

Technique for Making Angle-Independent Ultrasound Volume Flow Measurements

1710 – Volume flow measurements have always been the most desired ultrasound flow measurement. Unfortunately, such measreuments have been difficult to obtain or the accuray has been limited, and because of this, volume flow measurements are almost never used. The preferred embodiment is useful in an ultrasound system for measuring the volume of fluid flow within a region of interest. In... Read More

Synthetic nano-scale fibrous extracellular matrix

1566 – Biodegradable polymers have been widely used as scaffolding materials to regenerate new tissues. In addition to material biocompatibility, physical parameters of the material is central in the successful integration of the seeded cells into the biomaterial as well as the integration of the construct into the host upon implantation. Some of these physical parameters include the form of the... Read More

CIPER: A Novel Protein That Promotes Apoptosis and NF-kB Activation

1550 – Most cells in the body die through a non-inflammatory, energy-dependent form of cell death called apoptosis. Recent research into the molecular mechanisms of apoptosis has revealed that apoptosis is a genetically programmed process that can become deranged when the components of the cellular apoptotic machinery are mutated or present in inappropriate quantities. Dysregulation of apoptosis... Read More

Gas Foaming to Create Open Pore Structure

1360 – The lack of autologous and allogeneic tissue suitable for transplantation has driven the development of the tissue engineering field, in which new tissues are created from cultured cells and biomaterials. This is advantageous because these cells can be expanded in vitro and cultured for use by multiple patients. The biomaterial serves as a vehicle to localize the cells of interest, a... Read More

Isomers of 3-Hydroxymethyl Swainsonine

1314 – Swainsonine is a potent inhibitor of Golgi a-mannosidase II, a late-stage glycoprotein processing enzyme necessary for the incorporation of cancer-associated antigenic carbohydrates. Inhibition of this enzyme prevents the expression of these tumor-associated glycoproteins, resulting in good antitumor and antimetastatic activity without the usual cytotoxic effects of traditional... Read More

Thin-Film, Flat-Panel Dosimeter

1246 – Dosimetry is a measurement and/or calculation of absorbed dose of energy per unit mass of the irradiated target material. In medical applications, the target material is usually the patient, where several modes of diagnostics and therapy rely on ionizing irradiation, including radiotherapy, x-rays, electrons, protons, neutrons, and heavy ions. For example, in radiation therapy for cancer,... Read More

Fractional Moving Blood Volume Estimation with Power Doppler Ultrasound

1216 – In the diagnosis of various medical conditions, it is often useful to examine soft tissues and/or blood flow within the body to show structural details of organs and blood vessels in these organs. Multiple studies have demonstrated increased vascularity (blood flow) in many tumors relative to that of normal tissue, and multiple attempts have been made to depict these differences in... Read More

Cell Culture System for Propagation of Kaposi's Sarcoma Associated Virus (HHVS)

1177 – Kaposi’s sarcoma (KS) was originally described in the late 1800’s as a rare and relatively benign neoplasm of elderly men of Jewish or Mediterranean descent. Today, KS is recognized as the most common malignancy in AIDS patients, affecting approximately 20% of human immunodeficiency virus-1 (HIV-1)-positive patients (1-3). AIDS-related KS (also known as epidemic KS) is clinically more... Read More

Melanocortin-3, Melanocortin-4, and Melanocortin-5 Receptors

0853 – Melanocortins, products of pro-opiomelanocortin (POMC) post-translational processing, are known to have a broad array of physiological actions. Nakanishi, S. et al., Nature 278:423-427 (1979). Aside from their well known effects on adrenal cortical functions (adrenocorticotropic hormone, ACTH) and on melanocytes (melanocyte stimulating hormone, MSH), melanocortins have been shown to... Read More

Hybridoma Cell Line 1E7E8, Monoclonal Antibody UMCD2

0323 – Monoclonal antibody 1E7E8 specific for the CD2 molecule

Monoclonal Antibody UM4D4

0238 – Monoclonal antibody UMCD6

Barttin Mutation, Gene and Their Uses

2459 – Bartter syndrome is a rare autosomal recessive kidney disease characterized by the kidneys’ inability to reabsorb chloride (salt). Failure to reabsorb chloride leads to excessive salt delivery to the distal tubules of the kidney resulting in excessive salt and water loss from the body. This disease arises on average in 1.2-1.7 cases per 100,000 persons and is caused by mutations in the... Read More

visual depiction of patient's ability to get out of bed with or without assistance

Functional Independence Measure Software, Based on Barthel Index, Assesses Activities of Daily Living (ADLs) with Animated Images

4537 – This functional independence measurement tool is computer-animated medical diagnostic software, based on the commonly used Barthel Index, that evaluates a patient’s functional independence and quality of life prior to or during treatment for a traumatic injury, chronic disability, or disease. This functional independence assessment tool, called Language Independent Functional Evaluation... Read More

Page 2 of 2 12