Prognostics

Found 27 technologies within Prognostics RSS ATOM

SiMREPS Analysis Software - v 1.0

6250-1 – This package contains installers for two programs that perform single-molecule kinetic fingerprinting (SiMREPS=single-molecule recognition through equilibrium Poisson sampling) analysis using one or more grayscale TIF stacks (movies) as input. The first program generates intensity-versus-time traces form grayscale TIF stacks for subsequent kinetic analysis. The second program performs... Read More

Corticocardiac Coupling as a Risk Factor for Sudden Death

6687 – Sudden death occurs in more than 400,000 Americans annually and is a significant and under-recognized consequence of stroke. Identification of patients at risk for sudden death after stroke poses a major challenge. Recently, an animal model of stroke uncovered a surge in synchronous brain and heart electrical activity (corticocardiac coupling) hours before sudden death. This finding was... Read More

Analytic Morphomics: High Speed Medical Image Automated Analysis Method

4834 – Millions of medical imaging scans, such as computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) are taken each year to aid medical professionals in treating their patients. However, after the images have served their initial purpose, they are rarely referenced again. Recently, the informatics sciences have grown to encompass morphometry, or the... Read More

Machine Learning for Hepatitis C

6348 – This technology provides a novel method for the prognosis of Hepatitis C progression. Hepatitis C is often chronic, and of those with chronic Hepatitis C, ~65% eventually develop chronic liver disease, and ~15% develop cirrhosis which is often a precursor for liver cancer. It is currently difficult to predict which individuals will develop complications from chronic Hepatitis C infection. ... Read More

High-Confidence Single-Molecule Detection of RNA Biomarkers

6250 – Rapid, Amplification- and Label-Free, Ultrahigh-Confidence Counting of Single RNA and Other Biomarker Molecules in Patient Samples MicroRNAs (miRNAs) and other non-coding RNAs (ncRNAs) have recently emerged as promising diagnostic biomarkers for virtually all pathologies, including cancer, heart disease, diabetes, Alzheimer’s, and viral infection. We have developed a novel technology... Read More

Pharmacogenomic response and prognosis software without disease specificity

6337 – This technology predicts outcomes of pharmaceutical use based on data from previous patients to identify the best course of action, the major goal of pharmacogenomics. Many classes of disease have large percentages of patients who do not respond to medications, represented wasted time, money, and patient wellness. Understanding pharmacogenomics will help save tens of millions of dollars in... Read More

Renal Risk Index Calculator

6460 – The Renal Risk Index (RRI) uses patient qualities after transplant to predict the possibility of End-Stage Renal Failure (ESRD) in patients. ESRD affects 339 people per million, and can be caused by poor recipient response to liver transplantation. However, predicting which patients are most at risk for ESRD after liver transplantation is a difficult task. The RRI is a powerful measure of... Read More

Microfluidic Device for Capture and Release of Rare Cells

6590 – This technology describes a new microfluidic device which utilizes a blend film of graphene oxide (GO) sheets and thermally responsive polymers to enable efficient cell capture and release, including circulating tumor cells (CTCs). Current microfluidics-based CTC isolation technologies are capable of isolating, enumerating and characterizing CTCs, however, CTC release after selective... Read More

NPHP Nucleic Acids and Proteins

2417p1 – UM File # 2417p1 Background Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, constitutes the most frequent genetic cause for end-stage renal disease (ESRD) in children and young adults. NPHP is a progressive hereditary kidney disease marked by anemia, polyuria, renal loss of sodium, progressing to chronic renal failure, tubular atrophy, interstitial fibrosis, glomerular... Read More

PON3 and Uses Thereof

1855d1 – The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability to alter PON3 associated activities, methods for generating antibodies useful in the detection of PON3, and... Read More

Utilizing biomarkers to predict MDS patient sensitivity to DNA methyltransferase inhibitors

6380 – Myelodysplastic syndromes (MDS) and MDS/myeloproliferative (MDS/MPN) overlap syndromes are marrow stem-cell disorders characterized by ineffective haematopoiesis leading to a reduction in blood cells, with one-third of cases progressing to acute myeloid leukemia (AML). MDS can be a primary disease involving gene mutations and widespread gene hypermethylation at advanced stages, or can be a... Read More

Identification and targeting immune-activated transcriptional pathways for cancer stem cell immunotherapy in solid tumors

6033 – Identification and targeting immune-activated transcriptional pathways for cancer stem cell immunotherapy in solid tumors The cross-talk between immune system and cancer stem cells in the tumor microenvironment, and the mechanisms on how they interact to influence tumor development and progression is still not fully understood. Using tumor samples from ovarian and breast cancer patients,... Read More

Epithelial Mesenchymal Transition (EMT) Prognostic Signature for Non-small Cell Lung Cancer

5919 – Epithelial Mesenchymal Transition (EMT) Based Prognostic Signature for Non-small Cell Lung Cancer Recent advances in proteomics and genome sequencing have revolutionized an era of cancer therapy where clinical, proteomic and genomic information are used in assessing an individual’s risk for disease, prevention and treatment. Researchers at the University of Michigan used a TGF-β induced EMT... Read More

Biomarker for Chronic Diarrhea Associated with Irritable Bowel Syndrome

4920 – Irritable bowel syndrome (IBS) is a functional disorder of the intestine affecting the normal motility. IBS is characterized by abdominal pain and altered bowel habits in the absence of an obvious pathology. Based on bowel patterns, IBS can be subtyped into IBS-D (diarrhea predominant) or IBS-C (constipation predominant). Due to the limited knowledge about IBS pathogenesis, there is currently... Read More

NOTCH2 Mutations are Common in Splenic Marginal Zone Lymphoma and Predict a Poor Prognosis

5388 – Lymphomas are a heterogeneous group of hematological malignancies that accounts for ~5% of all cancers worldwide. Due to their heterogeneity, lymphomas vary significantly in their severity, from indolent to very aggressive forms. Thus, accurate diagnosis and prediction of disease progression is very important in determining the best treatment course for each patient. Splenic marginal zone... Read More

Modulation of EMT/MET States of Cancer Stem Cells

5299 – microRNAs, or miRNAs, are short pieces of non-protein-coding regulatory ribonucleic acid (RNA) averaging 20 nucleotides in length that were first discovered in 1993. To date, nearly 1000 have been identified in the human genome and are reported to play an active role in nearly every cell type. Interestingly, it has been reported that different cancers produce unique miRNAs, and several... Read More

Analysis of Pseudogene Expression in the Transcriptomic Landscape of Cancer

5067 – Cancer-specific pseudogenes were found by high throughput transcriptome analysis. Current evidence suggests that pseudogenes may provide another layer of gene regulation. Recent work to identify pseudogenes has been difficult given the high sequence similarity with coding genes. However, using RNA-Seq and high throughput sequencing, investigators were able to find and group pseudogenes... Read More

Diagnosis and Inhibition of Metastatic Prostate Cancer Using Raf-kinase Protein (RKIP) Gene Products

2104 – Cancer can be perceived as a disease resulting from breakdown of communication between and within cells. While there are many different effects, the changes in mitogen-activated protein kinase pathways play a profound role. Cancerous mutations in these pathways frequently affect Ras and Raf in the extracellular signal-regulated kinase pathway. Recent discoveries of activating mutations in... Read More

Therapy and Diagnosis of Cancer and Autoimmune Diseases

3732 – Breast cancer is the most common cancer among women, and the second most common cause of cancer death in women in the United States. Early detection and new treatments, as well as discovery of abnormalities in several genes involved in the development and progression of breast cancer, have improved the survival rates of breast cancer patients. Analysis of such genes may be a predictor of... Read More

Brain Tumor Marker

3667 – Existing cancer screening tests are often invasive, expensive, and lack strong diagnostic utility. For example, prostate cancer is typically diagnosed with a digital rectal exam and/or prostate specific antigen (PSA) screening, which has limited sensitivity and specificity. Thus, development of additional serum and tissue cancer biomarkers is needed to supplement current screening... Read More

Prognostic Markers for Cancer

3557 – Prostate cancer is a leading cause of cancer-related death in American men, second only to lung cancer. While clinically localized prostate cancer can be effectively ablated using surgical or radiation treatments, advanced disease, however, remains essentially incurable. It is therefore essential to distinguish aggressive versus indolent forms of prostate cancer at an earlier stage in... Read More

Breast Cancer Targeted Therapy

3524 – Breast cancer is the most common cancer among women worldwide and is the second most common cause of cancer death in women in the United States. Early detection and new treatments have improved survival rates of breast cancer. Particularly, a number of genes involved in the development and progression of breast cancer have abnormalities in breast cancers. Analysis of these genes for... Read More

Identification, Enrichment and Use of Mammalian Photoreceptor Precursors

3501 – According to the National Center for Health Statistics, National Health Interview Survey (Disability Supplement, 1994 and 1995), approximately 1.3 million people in the U. S. were legally blind, with estimated annual cost of $4 billion to the federal government. In the developed countries, a majority of diseases leading to untreatable blindness involve the death of photoreceptors. Since... Read More

Method for Diagnosing or Treating Prostate and Breast Cancer

3259 – According to the American Cancer Society, prostate and breast cancer have the highest rate of new diagnosis in the US with approximately 200,000 new diagnoses for each every year. There is a great need for tools and therapeutics that reliably detect and inhibit these cancers. Recent studies have indicated that more malignant prostate and breast cancer cell lines secrete vimentin, an... Read More

Identification of the Gene (NPHP4) Causing Nephronophthisis Type 4 and Retinis Pigmentosa

2417 – Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, constitutes the most frequent genetic cause for end-stage renal disease (ESRD) in children and young adults. NPHP is a progressive hereditary kidney disease marked by anemia, polyuria, renal loss of sodium, progressing to chronic renal failure, tubular atrophy, interstitial fibrosis, glomerular sclerosis, and medullary... Read More

Disturbance in the Neuropathy Target Esterase Pathway Causes Degenerative Neurologic Disease

2611 – Motor neuron disorders include amyotrophic lateral sclerosis, autosomal recessive spastic paraplegia, hereditary spastic paraplegia, primary lateral sclerosis, progressive pseudobulbar palsy, progressive muscular atrophy, progressive bulbar palsy, and postpolio syndrome. Symptoms characteristic for a specific type of motor neuron disorder vary according to the part of the nervous system... Read More

A Novel Gene and its Protein Product that when mutated Causes Myoclonus, Ataxia and Dystonia Syndromes, and Cayman Ataxia

2463 – Ataxia is a clinical sign of lack of muscle coordination, affecting a variety of voluntary movements such as walking, speech, and swallowing. It may also signify a group of degenerative diseases of the nervous system, which may be of sporadic or hereditary nature. Hereditary ataxia is a group of rare genetic neuromuscular disorders. It is often caused by a gene defect that produces... Read More