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Peptide Specific for Fibroblast Growth Factor Receptor 2 (FGFR2) for the Detection and Treatment of Epithelial-Derived Cancers
7309 – Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane receptor tyrosine kinase that signals cell division, growth and differentiation. Defects in FGFR2 expression and signaling are oncogenic and occur in some of the most aggressive and common cancer types, including breast, prostate, esophageal and colorectal cancer. FGFR2 is therefore a promising early cancer biomarker and an... Read More
A High-throughput Fluorescence Assay for the Determination of Spontaneous Viral Mutation Rates
7383 – The technology disclosed is a Luria-Delbruck fluctuation test for influenza virus mutation rates that scores reversion to fluorescence in a set of 12 mutant green fluorescent proteins (GFP). Globally, seasonal influenza is a major cause of severe respiratory infections, leading to excessive hospitalizations and 1 million deaths/year. The global influenza market (vaccines, antivirals, and... Read More
Moisture imaging of wound and burn depth for clinical assessment
6458 – Physicians and surgeons treating wounds and burns perform debridements simply according to how the insult looks. There is no objective or well-accepted method to assess wound depth or other characteristics. Punch biopsies may be used to evaluate wounds, but the procedure may impair restorative processes and cause infection. A single biopsy also does not allow for wound observation at multiple... Read More
Respiratory rhythm matrix (RRM), a new method for sleep apnea detection
6918 – Sleep apnea can be defined as a group of disorders characterized by abnormalities of breathing while sleeping. Breathing is interrupted from a few seconds to minutes, occurring several times over the course of a routine sleep. Airway blockage occurs as the patient sleeps. The blockage occurs between the soft palate and/or the back of the tongue and the pharynx. As the patient breathes, the... Read More
Corticocardiac Coupling as a Risk Factor for Sudden Death
6687 – Sudden death occurs in more than 400,000 Americans annually and is a significant and under-recognized consequence of stroke. Identification of patients at risk for sudden death after stroke poses a major challenge. Recently, an animal model of stroke uncovered a surge in synchronous brain and heart electrical activity (corticocardiac coupling) hours before sudden death. This finding was... Read More
Analytic Morphomics: High Speed Medical Image Automated Analysis Method
4834 – Millions of medical imaging scans, such as computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) are taken each year to aid medical professionals in treating their patients. However, after the images have served their initial purpose, they are rarely referenced again. Recently, the informatics sciences have grown to encompass morphometry, or the... Read More
Targeted absolute quantitative proteomics assay
6740 – The rapidly expanding field of proteomics is changing the way we understand cellular function, and paving the path for new diagnostics and medicines each day. The proteomics industry is projected to expand at a rate of 19% per year to a market value of approximately $12B by 2019, making it one of the fastest growing scientific markets in the world. As the medical and pharmaceutical fields... Read More
Applications of novel ErbB2 selective peptides
6579 – The membrane receptor ErbB2 (also known as HER2/neu) is a member of the epidermal growth factor receptor (EGFR) family. ErbB2 is amplified and overexpressed in many epithelial-derived malignancies including breast, ovarian, and lung cancers. Agents capable of selectively targeting ErbB2 can be used for diagnostics, prognostic indications, imaging and therapeutic applications. The... Read More
An automated high-throughput method for identifying long non-coding RNAs associated with cancer
6286 – Cancer is the second leading cause of death in the United States. While recent efforts at analyzing the transcriptome of cancer patients have focused on studying protein-encoding genes, several long non-coding RNA (lncRNA) transcriptions have been found to promote oncogenesis. Previous attempts at identifying these cancer-associated lncRNAs have been limited. The evolution of high-throughput... Read More
Machine Learning for Hepatitis C
6348 – This technology provides a novel method for the prognosis of Hepatitis C progression. Hepatitis C is often chronic, and of those with chronic Hepatitis C, ~65% eventually develop chronic liver disease, and ~15% develop cirrhosis which is often a precursor for liver cancer. It is currently difficult to predict which individuals will develop complications from chronic Hepatitis C infection. ... Read More
High-Confidence Single-Molecule Detection of RNA Biomarkers
6250 – Rapid, Amplification- and Label-Free, Ultrahigh-Confidence Counting of Single RNA and Other Biomarker Molecules in Patient Samples MicroRNAs (miRNAs) and other non-coding RNAs (ncRNAs) have recently emerged as promising diagnostic biomarkers for virtually all pathologies, including cancer, heart disease, diabetes, Alzheimer’s, and viral infection. We have developed a novel technology... Read More
Pharmacogenomic response and prognosis software without disease specificity
6337 – This technology predicts outcomes of pharmaceutical use based on data from previous patients to identify the best course of action, the major goal of pharmacogenomics. Many classes of disease have large percentages of patients who do not respond to medications, represented wasted time, money, and patient wellness. Understanding pharmacogenomics will help save tens of millions of dollars in... Read More
Renal Risk Index Calculator
6460 – The Renal Risk Index (RRI) uses patient qualities after transplant to predict the possibility of End-Stage Renal Failure (ESRD) in patients. ESRD affects 339 people per million, and can be caused by poor recipient response to liver transplantation. However, predicting which patients are most at risk for ESRD after liver transplantation is a difficult task. The RRI is a powerful measure of... Read More
Microfluidic Device for Capture and Release of Rare Cells
6590 – This technology describes a new microfluidic device which utilizes a blend film of graphene oxide (GO) sheets and thermally responsive polymers to enable efficient cell capture and release, including circulating tumor cells (CTCs). Current microfluidics-based CTC isolation technologies are capable of isolating, enumerating and characterizing CTCs, however, CTC release after selective... Read More
Polycolonal antibodies for various species of fluorescent proteins
6416 – With billions of neurons connected by trillions of synapses, the brain is by far the most intricate and complex organ. A complete map of the brain’s connections will be essential to understanding its function. Some of the tools that have been invaluable towards creating this map are the colorful range of fluorescent proteins used to label individual neurons and subcellular structures. ... Read More
Novel oncogenic TYK2 gene fusion identified as biomarker for cutaneous T-cell lymphoma
6283 – Cutaneous T-cell lymphomas (CTCL) are the most frequent primary lymphomas of the skin, with mycosis fungioides being the most prevalent form accounting for 60% of cases. Although CTCL is treatable in early stages, its diagnosis can be difficult due to the lack of specific biomarkers and dependence on clinical and histological observations that can be misdiagnosed as benign skin diseases. In... Read More
MAP2K1 (MEK1) mutations in Langerhans Cell Histiocytosis
6281 – Langerhans Cell Histiocytosis (LCH) is a rare and complicated disease. The pathophysiology of this disorder is still debated. Around half of all LCH cases present with a mutation in the gene BRAF resulting in a constitutively active protein. Until recently the other half of patients were left without knowledge of what is driving the disease. This technology identifies another driving mutation... Read More
Primary Aldosteronism Molecular Diagnostic
6338 – High blood pressure affects over 970 million people worldwide. Of these, over 38 million are expected to have primary aldosteronism (PA), a medication resistant form of high blood pressure that requires special treatment. With currently over 3 million patients domestically, the US incidence of PA is expected to increase as the population grows older and heavier. Current methods for diagnosing... Read More
Peptide Biomarkers for Diagnosis of Colorectal Cancer
6269 – Colorectal cancer is the third most diagnosed cancer, with 1.4 million new cases worldwide in 2012. In the United States alone in 2014, an estimated 136,830 new cases will be diagnosed, and about 50,310 deaths will result from the disease. Ninety percent of patients survive if diagnosed during the localized stage of colorectal cancer (5-year survival rate), but only 40% of colorectal cancer... Read More
The Use of IL-6 Targeted Therapies in Overcoming Trastuzumab Resistance
5193 – As a fifth leading cause of cancer-related death, 1 out of 8 U.S. women will develop invasive breast cancer over the course of her lifetime. Among all breast cancer cases, 20% to 25% make too much of protein known as human epidermal growth factor receptor 2 (HER2). These breast cancers are known be fast growing and much more aggressive than other types of breast cancer. Treatment using... Read More
NPHP Nucleic Acids and Proteins
2417p1 – UM File # 2417p1 Background Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, constitutes the most frequent genetic cause for end-stage renal disease (ESRD) in children and young adults. NPHP is a progressive hereditary kidney disease marked by anemia, polyuria, renal loss of sodium, progressing to chronic renal failure, tubular atrophy, interstitial fibrosis, glomerular... Read More
PON3 and Uses Thereof
1855d1 – The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability to alter PON3 associated activities, methods for generating antibodies useful in the detection of PON3, and... Read More
Utilizing biomarkers to predict MDS patient sensitivity to DNA methyltransferase inhibitors
6380 – Myelodysplastic syndromes (MDS) and MDS/myeloproliferative (MDS/MPN) overlap syndromes are marrow stem-cell disorders characterized by ineffective haematopoiesis leading to a reduction in blood cells, with one-third of cases progressing to acute myeloid leukemia (AML). MDS can be a primary disease involving gene mutations and widespread gene hypermethylation at advanced stages, or can be a... Read More
Molecular Markers of Prostate Cancer Progression
3552 – UM File # 3552 Background Afflicting one out of nine men over age 65, prostate cancer is a leading cause of male cancer-related death. Prostate cancer is typically diagnosed with a digital rectal exam and/or prostate specific antigen (PSA) screening. PSA is used as a marker for prostate cancer because only prostate cells secrete it. However, a major limitation of the serum PSA test is a lack... Read More
Novel epithelial growth factor receptor – targeting peptides for cancer detection
5992 – Colorectal cancer is the third most common type of cancer in the U.S., causing over 50,000 deaths annually. However, this deadly cancer can be cured through routine screening and diagnosis at early stages. Epithelial growth factor receptor (EGFR) is a cell surface marker that stimulates cell growth, proliferation and differentiation. EGFR is overexpressed in several kinds of cancer (compared... Read More
Novel predictive and pharmacodynamic serum biomarkers for treatment with L-carnitine in patients with sepsis
6190 – Sepsis represents one of the fastest growing health-care problems today, and is responsible for more than 250,000 deaths every year. Annually, over 2.5 million patients are admitted to intensive care units due to severe sepsis and healthcare costs associated with sepsis exceeds $17 billion in the US alone. Despite the advancements in the sepsis treatment, management of the illness is... Read More
Smart dental composite material utilizing thiol–ene polymerization mechanism to reduce resin shrinkage.
6131 – According to the U.S Census Bureau, in 2010 nearly 36 million people age of 65 and over lived in the United States, accounting for just over 12% of the total population. Oral diseases and conditions are common among these Americans who grew up without the benefit of community water fluoridation and other fluoride products. The older population in 2030 is projected to be twice as large as in... Read More
Delta-like 4 as a biomarker for tuberculosis diagnosis
6122 – Tuberculosis (TB) infection caused by Mycobacterium tuberculosis is second leading cause for deaths worldwide resulting from a single infection after HIV/AIDS. Currently, 19-43.5% of the world’s population is infected with M. tuberculosis of which 75% of the cases reported are in underdeveloped and developing countries. Most infections are latent and only 1 in 10 infected individuals progress... Read More
Identification and targeting immune-activated transcriptional pathways for cancer stem cell immunotherapy in solid tumors
6033 – Identification and targeting immune-activated transcriptional pathways for cancer stem cell immunotherapy in solid tumors The cross-talk between immune system and cancer stem cells in the tumor microenvironment, and the mechanisms on how they interact to influence tumor development and progression is still not fully understood. Using tumor samples from ovarian and breast cancer patients,... Read More
Rare targetable recurrent RAF gene fusions in advanced prostate cancer, gastric cancer and melanoma
4829 – Recurrent gene fusions are a unique class of genetic aberrations that are widespread and are the hallmark of several types of cancer. Currently known recurrent fusions, that were identified in prostate cancer phenotypes, involve erythroblastosis virus E26 transformation-specific (ETS) family transcription factors and their products are considered ‘undruggable’ by conventional approaches.... Read More
SLC45A3-BRAF, Rare targetable recurrent androgen responsive RAF gene fusions in advanced prostate cancer
4374 – Recurrent gene fusions are a unique class of genetic aberrations that are widespread and are the hallmark of several types of cancer. Currently known recurrent fusions, that were identified in prostate cancer phenotypes, involve erythroblastosis virus E26 transformation-specific (ETS) family transcription factors and their products are considered undruggable by conventional approaches.... Read More
Uses of Flavivirus Protein 3D Structure and Protein Production
5988 – Described here is the 3-dimensional structure of the flavivirus nonstructural glycoprotein (NS1) as well as the methodology to produce, isolate, and purify NS1. In the fields of infectious diseases and virology this technological development will be group breaking for the development of vaccines, antivirals, antibodies, and diagnostics for the treatment of multiple infections from this... Read More
Epithelial Mesenchymal Transition (EMT) Prognostic Signature for Non-small Cell Lung Cancer
5919 – Epithelial Mesenchymal Transition (EMT) Based Prognostic Signature for Non-small Cell Lung Cancer Recent advances in proteomics and genome sequencing have revolutionized an era of cancer therapy where clinical, proteomic and genomic information are used in assessing an individual’s risk for disease, prevention and treatment. Researchers at the University of Michigan used a TGF-β induced EMT... Read More
Urinary Biomarkers of Lower Urinary Tract Symptoms in Women with Cystocele
5916 – Biomarkers are increasingly being identified as objective and non invasive tools in clinical diagnosis of Lower urinary tract symptoms (LUTS) associated with cystocele (pelvic organ prolapse or bladder prolapse), overactive bladder (OAB), etc. LUTS are a group of symptoms that include discomfort and problems with emptying the urinary bladder. LUTS is associated with pelvic floor disorders... Read More
Fusion peptides from oncogenic chimeric proteins as specific biomarkers of cancer
5840 – Researchers at University of Michigan developed a method to diagnose cancer subtypes involving chromosomal translocation. Chromosomal translocations encoding chimeric fusion proteins constitute one of the most common mechanisms underlying oncogenic transformation in human cancer. Current approaches to identify chromosomal translocation include fluorescent in situ hybridization (FISH) and... Read More
Activating Estrogen Receptor Mutations in Hormone Resistant Metastatic Breast Cancer
5884 – Activating Estrogen Receptor Mutations in Hormone Resistant Metastatic Breast Cancer Recent advances in genome sequencing have revolutionized an era of cancer therapy where clinical and genomic information are used in assessing an individual’s risk for disease, prevention and treatment. Researchers from the University of Michigan collected normal tissue, primary diagnostic tumors and... Read More
Biomarker for Chronic Diarrhea Associated with Irritable Bowel Syndrome
4920 – Irritable bowel syndrome (IBS) is a functional disorder of the intestine affecting the normal motility. IBS is characterized by abdominal pain and altered bowel habits in the absence of an obvious pathology. Based on bowel patterns, IBS can be subtyped into IBS-D (diarrhea predominant) or IBS-C (constipation predominant). Due to the limited knowledge about IBS pathogenesis, there is currently... Read More
RNA Chimeras in Human Leukemia and Lymphoma
5734 – Chimeric RNA as a diagnostic marker of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL) Using paired-end tag sequencing of RNA transcripts from chronic lymphocytic leukemia (CLL) patients, researchers at the University of Michigan have identified nine chimeric RNAs expressed in CLL patients. Among these chimeric RNAs are two recurrent and reciprocal chimeric RNA that was... Read More
Monoclonal Antibodies Against a Cancer Marker
2164p1 – UM File # 2164p1 Background Existing cancer screening tests are often invasive, expensive, and lack strong diagnostic utility. For example, prostate cancer is typically diagnosed with a digital rectal exam and/or prostate specific antigen (PSA) screening, which has limited sensitivity and specificity. Thus, development of additional serum and tissue cancer biomarkers is needed to supplement... Read More
TERSE: Transmission and Emission Reconstruction Software Environment
0873 – TERSE: a transmission and emission reconstruction environment for SPECT, has been developed at the University of Michigan by Jeff Fessler and Edward Ficaro, in a collaboration between the Department of Electrical Engineering and Computer Science (EECS) and the Division of Nuclear Medicine. TERSE consists of an X-windows graphical user interface to portions of the ASPIRE software libraries... Read More
Cell-Specific Mineralocorticoid Receptor Theranostics for Inflammatory Diseases
5525 – Current mineralocorticoid receptor (MR) antagonists have side effect when treating cardiovascular diseases. Activation of MRs promotes inflammation and cardiovascular disease. Patients suffer from these diseases can benefit from MR blockage by MR antagonists, such as spironolactone and eplerenone. However, these traditional MR antagonists have limitations including off-target effects and... Read More
Methods for the detection and diagnosis of osteoporosis and osteogenesis imperfecta using atomic force microscopy
5466 – This technology utilizes atomic force microscopy (AFM) imaging and two-dimensional fast Fourier transform (2D FFT) analysis to examine collagen fibril D-spacing in collagenous tissues. Collagen is the major building block of many human tissues, including skin, tendons, and bone. Structurally, collagen molecules are arranged into fibrils that contain repeating staggered gaps termed D-periodic... Read More
Universal, Quantitative Antibody Labeling Platform
5514 – Newly developed antibody-conjugated fluorophore-labeled dendrimers offer improved sensitivity and quantitative analysis for a wide range of research and clinical applications. Current antibody labeling strategies are prone to batch-to-batch variability and are dependent on stochastic chemical reactions. Utilizing modified PAMAM dendrimer nanoparticles for antibody labeling with fluorophores... Read More
Diagnostic Polymerase Chain Reaction for Uropathogenic Escherichia Coli
5236 – Almost 50% of the global population will experience a urinary tract infection (UTI) at some point in their lives, and those who suffer from recurrent, UTI can have three or more episodes of infection per year. As the most common healthcare-associated infection, UTI accounts for more than 30% of infections reported by acute-care hospitals. Strains of bacteria known as uropathogenic E. coli... Read More
Hybrid Multichannel Printed Circuit Board Microdrive
3822 – Over 10 million people in the U.S. suffer from an advanced form of a neurodegenerative disease such as Parkinson’s, Epilepsy, and Alzheimer’s. There has been theory, changing breakthroughs in the last 15 years regarding how these disease progress and manifest symptoms in patients. By working in the animal model, scientists have been able to experiment more freely and tackle more advanced... Read More
NOTCH2 Mutations are Common in Splenic Marginal Zone Lymphoma and Predict a Poor Prognosis
5388 – Lymphomas are a heterogeneous group of hematological malignancies that accounts for ~5% of all cancers worldwide. Due to their heterogeneity, lymphomas vary significantly in their severity, from indolent to very aggressive forms. Thus, accurate diagnosis and prediction of disease progression is very important in determining the best treatment course for each patient. Splenic marginal zone... Read More
Modulation of EMT/MET States of Cancer Stem Cells
5299 – microRNAs, or miRNAs, are short pieces of non-protein-coding regulatory ribonucleic acid (RNA) averaging 20 nucleotides in length that were first discovered in 1993. To date, nearly 1000 have been identified in the human genome and are reported to play an active role in nearly every cell type. Interestingly, it has been reported that different cancers produce unique miRNAs, and several... Read More
Analysis of Pseudogene Expression in the Transcriptomic Landscape of Cancer
5067 – Cancer-specific pseudogenes were found by high throughput transcriptome analysis. Current evidence suggests that pseudogenes may provide another layer of gene regulation. Recent work to identify pseudogenes has been difficult given the high sequence similarity with coding genes. However, using RNA-Seq and high throughput sequencing, investigators were able to find and group pseudogenes... Read More
Signaling Pathways Involved in Prostate Cancer
3312 – After skin cancer, prostate cancer is the most common type of cancer found in American men. An estimated 220,000 new cases of prostate cancer will be diagnosed in the United States in 2007. Prostate cancer is the second leading cause of cancer death in men with a death rate of approximately 27,000 patients per year. The levels of prostate specific antigen (PSA) are often high in men with... Read More
1B6 Hybridoma Secreting a Murine Monoclonal Antibody Specific for Rat CD11b
1613 – Murine monoclonal antibody specific for the rat form of the beta2 integrin glycoprotein alpha subunit CD11b