Research Technology & Tools

1-50 of 132 technologies within Research Technology & Tools RSS ATOM

The cryopreservation of human tissue samples for subsequent culture of live tissue

7532 – Over the past several decades, there has been an increasing need for better cryopreservation of tissue samples as well as increased research to tackle this problem. To-date there is a large amount of media used for the cryopreservation of cells from culture. However, there are still issue with freezing and thawing live tissue samples. This is largely due to crystallization that occurs on the... Read More

Peptide Specific for Fibroblast Growth Factor Receptor 2 (FGFR2) for the Detection and Treatment of Epithelial-Derived Cancers

7309 – Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane receptor tyrosine kinase that signals cell division, growth and differentiation. Defects in FGFR2 expression and signaling are oncogenic and occur in some of the most aggressive and common cancer types, including breast, prostate, esophageal and colorectal cancer. FGFR2 is therefore a promising early cancer biomarker and an... Read More

Generation of a Floxed TERT mouse for conditional analysis of telomerase function

7354 – Telomeres are important for protecting the ends of chromosomal DNA as we age. They progressively shorten over time, but this process may undergo abnormal alteration during disease such as cancer. Telomerase is the enzyme complex responsible for extension of telomeres. More specifically, telomerase reverse transcriptase (TERT) is the catalytic portion of this complex responsible for telomere... Read More

FIZZ1 Knockout Mouse

7353 – FIZZ1 (found in inflammatory zone) is a cysteine rich secreted protein. It is encoded by a gene known as Retnla or Remα. Upon deletion or overexpression of the gene, researchers have found that it has many roles in the regulation of fibrosis, pulmonary allergic inflammation, immune response, tissue remodeling, wound healing, and infection. However, most of the studies to date have been... Read More

Hydro-Seq: High Sample Efficiency Single Cell Whole Transcriptome Analysis Technology

7243 – To adequately diagnose and treat cancer, cancer cells are studied for particular gene expressions. Research has shown that the most important cells to look for are circulating tumor cells (CTCs) as these give rise to cancer. Traditional technologies for studying gene expression look at a population average, which masks diversity that is often seen in cancer patients. It is estimated that CTCs... Read More

Development of Amnion-Like Tissue From Human Pluripotent Stem Cells

7115 – The amniotic membrane (AM) forms the inner layer of placenta surrounding a fetus during pregnancy, allowing successful embryonic implantation, providing protection against physical trauma, maintenance of constant temperature, and amniotic fluid flow that assists in musculoskeletal development. Failure of the embryo to implant contributes to loss of pregnancy, which occurs at a rate of 10-12%... Read More

Scalable Multiplexed Drug-Combination Screening Platform Using 3d Microtumor Model for Precision Medicine

7222 – Drug Combinations have been an advantageous for the treatment of cancer as targeting two pathways can lead to an improvement in efficacy and has been shown to aid in overcoming resistance mechanisms. Clinical trials involving combinational therapies are very costly and time consuming, thus most pharmaceutical companies first assess drug combinations in-vitro. Current screening methods make... Read More

IMassFrag: Metabolite Identification Software

7009 – IMetabolite identification (MetID) of drug candidates is a critical step in drug discovery and development. MetID can aid medicinal chemists in modifying the metabolic soft spots of a drug candidate in the early stage of drug discovery. Metabolic modification of the compounds may change the pharmacological activity and toxicity of a drug molecule. To reduce the risk of costly... Read More

Effects on the Controlled Release of Proteins

2865 – UM File # 2865 Background Injectable biodegradable polymeric particles (usually microspheres) represent an exciting approach to control the release of vaccine antigens to reduce the number of doses in the immunization schedule and optimize the desired immune response via selective targeting of antigen to antigen presenting cells. After the first couple of decades of their study, much... Read More

High-Density Genotyping Panel for Genetic Analysis of Outbred Rats

6945 – The laboratory rat serves an important role as an animal model in biological research including the fields of psychology, medicine and new drug development. Many labs utilize congenic rat strains for their research, but studies done in certain fields require outbred strains of rats and mice to be used. One example is in the field of genetics for quantitative trait locus mapping where small... Read More

Targeted absolute quantitative proteomics assay

6740 – The rapidly expanding field of proteomics is changing the way we understand cellular function, and paving the path for new diagnostics and medicines each day. The proteomics industry is projected to expand at a rate of 19% per year to a market value of approximately $12B by 2019, making it one of the fastest growing scientific markets in the world. As the medical and pharmaceutical fields... Read More

An automated high-throughput method for identifying long non-coding RNAs associated with cancer

6286 – Cancer is the second leading cause of death in the United States. While recent efforts at analyzing the transcriptome of cancer patients have focused on studying protein-encoding genes, several long non-coding RNA (lncRNA) transcriptions have been found to promote oncogenesis. Previous attempts at identifying these cancer-associated lncRNAs have been limited. The evolution of high-throughput... Read More

Software for Identification of Common Protein-Protein Interfaces with Applications to Viral Inhibitors and Vaccines

6496 – Interactions between proteins are ubiquitous in biology and have recently garnered much attention from the drug discovery and protein engineering community. Although evidence suggests about 80% of proteins exists in one or more protein complexes during their lifetimes, relatively little is known about the structural evolution of protein interfaces and how they can be exploited as drug... Read More

G protein-coupled receptor kinase inhibitors to treat heart failure

6497 – Heart failure (also known as congestive heart failure) occurs when the heart becomes too weak to pump enough blood to meet the body’s oxygen requirements. In the United States, over 5 million people have heart failure, and the disease contributes to approximately 260,000 deaths (one in every nine deaths total) annually. In addition, heart failure costs the country an estimated $32 billion... Read More

beta1/Contactin Cell Line

mta2585 – beta1/Contactin Cell Line

Methods for Converting Stem Cells Into 3D Lung Tissues Through Directed Differentiation

6573 – Currently, there is a challenge in studying organ development and organ diseases. In vivo animal models are time consuming, difficult to study, and often don’t directly mimic a human organ system. Therefore, there has been a drive to create an in vitro model that better resembles a human system. Scientists have been able to drive human pluripotent stem cells (hPSCs) in to specific organ cell... Read More

Generation of Ag18F and its use in the synthesis of PET radiotracers

6465 – UM File # 6465 Background Technology Description Applications Advantagesission tomography (PET) is an imaging technique that relies on the decay of radioactive elements within a small molecule probe to produce an image of the spatial distribution of the probe in diseased tissues. Despite its promising applications in fields like oncology, neurology, and cardiology; PET has seen limited... Read More

Metamaterial Sensor Platforms for Terahertz DNA Sensing

6246 – Terahertz sensors are a promising technology for studying DNA hybridization due to the distinctive refractive response differences between single-strand and double-strand DNA polynucleotides. This inherent difference opens the door to highly sensitive label-free detection and identification of DNA sequences. A new sensing platform now promises to greatly increase the sensitivity of DNA... Read More

Overnight Corneal Reshaping - Quality of Life (OCRQOL) Questionnaire

6529 – Over half of all Americans use corrective eyewear such as glasses and contact lenses. When choosing corrective eyewear, doctors are concerned with safety, efficacy, visual acuity, and complication rates, while patients typically consider how different options affect their vision-related quality of life. All of these factors must be considered to find an ideal treatment. An important method... Read More

Novel method to obtain mature human stem cell derived cardiovascular cells for drug discovery and therapeutic applications

6203 – UM File # 6203 Background Technology Description Applications Advantagesare revolutionizing the drug discovery and development process used by pharmaceutical companies to identify lead drug candidates that provide opportunities to build innovative cellular models. Induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to an embryonic stem cell. The... Read More

Luminescent Heteromatallic Metallacrown Complexes for Biological Assays and Imaging

6312 – Sensitized lanthanides are becoming increasingly important across multiple scientific industries because of their stability, long luminescence lifetimes, and narrow emission bands. In the growing field of biological assays there has been demonstrated need for luminescent dyes that emit outside of the visible range where traditional fluorescence measurements suffer from high levels of... Read More

A You Tube Channel Communicating About the Science Behind Human Health Risks

6060 – Have you ever wondered if green potato chips are safe to eat? Or whether peeing in the swimming pool is a good idea? Or what makes something toxic?

Neuroanatomy Board Game - The Lesion: Charcot's Tournament

6231 – The use of board games as educational tools has led to the creation of games which re-emphasize material learned in class and allow for the development of greater understanding of complex issues. Games designed for medical education cover a wide variety of topics and number up to 184 games relating to medicine produced since 1935. With 17,000 medical school graduates in the US each year, the... Read More

Polycolonal antibodies for various species of fluorescent proteins

6416 – With billions of neurons connected by trillions of synapses, the brain is by far the most intricate and complex organ. A complete map of the brain’s connections will be essential to understanding its function. Some of the tools that have been invaluable towards creating this map are the colorful range of fluorescent proteins used to label individual neurons and subcellular structures. ... Read More

New tools enabling genetic manipulations in C. elegans

6584 – C. elegans is a commonly used model organism in research in life sciences. RNA interference (RNAi) is a form of genetic manipulation, which allows for stopping gene expression and therefore revealing the functions of genes. RNAi delivered by bacteria in C. elegans’ diet is one of the most widely used methods for gene knockdown in C. elegans field. Currently, bacteria strain HT115 is used... Read More

Single Nucleotide Polymorphisms in Escherichia coli and Pseudominas putida for improved biomass hydrothermal liquefaction applications

6436 – Genetic modifications in Escherichia coli and Pseudomonas putida for improved tolerance and utilization of aqueous product from algal biomass hydrothermal liquefaction Hydrothermal liquefaction (HTL) is a technology used to convert algae biomass into “biocrude” oil, a potential drop-in substance for petroleum. HTL eliminates land usage and provides a more complete biomass conversion than... Read More

Software for RNA Structure and Dynamics Elucidation from NMR Data.

6481 – With the discovery of ribozymes and the multitude of regulatory functions performed by RNA, great effort is being directed toward high resolution characterization of RNA 3D structure. Because of the dynamic nature of RNA, static structures are not sufficient for the functional studies necessary for drug design. Nuclear Magnetic Resonance (NMR) is a tool that captures structural data across... Read More

Reconfigurable Mesh Filters for Broadband Terahertz/Infrared Wave Modulation

5731 – A research team at the University of Michigan has developed a terahertz (THz) modulator that exhibits broadband, high amplitude modulation index. The use of THz technologies in many industries including semiconductor metrology, food quality processing, homeland security, medical imaging and communications, has led to staggering growth in the field in the last decade. Efficient light sources... Read More

Terahertz DNA Bio-Sensor Architecture Comprising Doubly-Corrugated Spoofed Surface Plasmon Polariton Waveguide

5568 – A label-free, Mach-Zehnder interferometer (MZI) based biosensor has been developed by a research team at the University of Michigan. The biosensor has potential to detect molecular binding without the use of conventional fluorescent tags, easing preparation requirements and facilitating efficient analysis. Biosensing has become increasingly important to many industries including biodefense,... Read More

Human Gene Expression Cassettes for Effective Intracellular Delivery of Small Interfering RNA

2190 – No summary available

Ruthenium Dehydrogenation Catalysts

6209 – Ruthenium Dehydrogenation Catalysts

Nitric Oxide Synthase Proteins

6031 – Nitric Oxide Synthase Proteins

Novel Imaging Probe for Detection of Cysteine Oxidation in Living Systems

6245 – Post-translation modification (PTM) is a step in protein synthesis where a biochemical functional group is attached to an amino acid thereby changing its chemical nature and/or structure. Often times these modifications are critical to the function of the protein and can be detected by various techniques including Mass Spectrometry, NMR, etc. Protein sulfenylation (Cys-SOH) is one such... Read More

Topo-EP

5489 – High affinity gene enhancers predicted by newly developed algorithm An enhancer prediction software, TOPO-EP, was developed to predict high affinity gene enhancers. In silico methods have frequently been used to identify gene enhancers in Drosophila. However, these methods can be costly and time consuming. An algorithm that predicts sites enriched in transcription factor binding sites was... Read More

MetaboID: A Graphical User Interface Package for Assignment of 1H NMR Spectra of Bodyfluids and Tissues

5476 – Metabolomics and system biology: Next-generation medical diagnostics The advancement of metabolomics, which is the study of biological fluids in order to diagnose diseases, has allowed us to begin painting pictures of what is happening inside a cell or tissue. In particular, nuclear magnetic resonance is a promising method to analyze metabolites on a large scale, and has proven its success in... Read More

Rare targetable recurrent RAF gene fusions in advanced prostate cancer, gastric cancer and melanoma

4829 – Recurrent gene fusions are a unique class of genetic aberrations that are widespread and are the hallmark of several types of cancer. Currently known recurrent fusions, that were identified in prostate cancer phenotypes, involve erythroblastosis virus E26 transformation-specific (ETS) family transcription factors and their products are considered ‘undruggable’ by conventional approaches.... Read More

SLC45A3-BRAF, Rare targetable recurrent androgen responsive RAF gene fusions in advanced prostate cancer

4374 – Recurrent gene fusions are a unique class of genetic aberrations that are widespread and are the hallmark of several types of cancer. Currently known recurrent fusions, that were identified in prostate cancer phenotypes, involve erythroblastosis virus E26 transformation-specific (ETS) family transcription factors and their products are considered undruggable by conventional approaches.... Read More

Uses of Flavivirus Protein 3D Structure and Protein Production

5988 – Described here is the 3-dimensional structure of the flavivirus nonstructural glycoprotein (NS1) as well as the methodology to produce, isolate, and purify NS1. In the fields of infectious diseases and virology this technological development will be group breaking for the development of vaccines, antivirals, antibodies, and diagnostics for the treatment of multiple infections from this... Read More

Highly Near Infrared Luminescent Lanthanide Encapsulated Sandwich Metallacrown Complexes

5760 – These are luminescent lanthanide complexes that have excellent photophysical properties that make them ideal for use in bioanalytical assays and biological imaging applications. These near-infrared (NIR) emitting luminophores show very high quantum yields and long luminescence lifetimes that are compatible with aqueous environments. Although lanthanides have several advantages over... Read More

A high-throughput system for continuous analysis of feeding behaviors in Drosophila

5987 – Understanding the physiology and regulation of feeding behavior in animals is essential for addressing biomedical problems such as obesity and feeding disorders. Feeding is a complex integration of internal and external stimuli that leads to the activation of an organized sequence of motor patterns in animals. Model systems such as Drosophila melanogaster (fruit flies) have been employed... Read More

Functionalized Dendrimer Detection Using Click Chemistry

4902 – This is a bioorthogonal reporter system that consists of a functionalized polyamidoamine (PAMAM) dendrimer capable of click chemistry used for monitoring of nanoparticle trafficking in complex biological systems. Dendrimers conjugated to bioactive molecules can be used for targeted delivery of therapeutic and imaging agents for many biological applications. Dendrimers and other nanoparticles... Read More

Monoclonal Antibody to Lysosomal Phospholipase A2

3891 – UM File # 3891 Background Lysosomes are intracellular organelles containing hydrolytic enzymes required for intracellular digestion of cellular and foreign materials such as cell fragments, microorganisms, surfactant, lipoproteins, and other pathogens. These enzymes are characterized by having acidic pH optima. In macrophages, acid Phospholipase A2 is secreted in response to phagocytic... Read More

Mouse Model for Human Norovirus

5085 – UM File # 5085 Background Human noroviruses are the most common cause of foodborne disease worldwide. In the United States, they cause approximately 23 million infections each year, which amounts to over two-thirds of all foodborne gastroenteritis outbreaks. With their low infectious dose (18 – 1,000 virus particles), stability on inanimate surfaces, and resistance to conventional cleaning... Read More

Chemoselective Probes for Nitrosothiol Detection

5758 – Nitric oxide (NO) is a key biological molecule in many aspects of health and disease. Certain thiol groups of amino acid are reversibly modified by nitric oxide and form S-Nitrosothiol modifications. Some of these modifications have been shown to alter in several pathological conditions, such as Alzheimer’s disease, Parkinson’s disease, stroke, heart disease, pulmonary and musculoskeletal... Read More