Gastroenterology

Found 10 technologies within Gastroenterology RSS ATOM

Identification and Use of Intestinal Resident Bacteria that Mediate Protection Against Enteric Pathogens

7130 – The high susceptibility of neonates to intestinal infections has been assumed to be largely due to immaturity of the immune system, but the mechanism remains unclear. Resident intestinal bacteria provide several benefits to the host. A major function of the gut microbiota is to protect the host against colonization by pathogens; however, the specific group of bacteria that mediates... Read More

Device for Fixation of an Adjustable Length Tube Through a Preformed Tract into a Hollow Cavity

6633 – Patients who can’t get enough food or liquids through the oral route use an enteral feeding tube. This may be due to decreased appetite, difficulty in swallowing and post-surgery that interferes with eating. The tube transfers food directly into the stomach through the abdominal skin via a surgically-created tract. Feeding tube is preferred for patients who require long-term nutrition... Read More

Atraumatic Tip Geometry for Endoluminal Devices

6453 – Enteral nutrition refers to the delivery of nutrients directly to the gastrointestinal tract, and is used for patients who are unable to eat normally due to illnesses or surgeries. Formulae are introduced into the stomach and intestines using feeding tubes, passed through the nose or skin. These tubes are semi-rigid in nature, and do not always readily conform to the convoluted and curved... Read More

Novel epithelial growth factor receptor – targeting peptides for cancer detection

5992 – Colorectal cancer is the third most common type of cancer in the U.S., causing over 50,000 deaths annually. However, this deadly cancer can be cured through routine screening and diagnosis at early stages. Epithelial growth factor receptor (EGFR) is a cell surface marker that stimulates cell growth, proliferation and differentiation. EGFR is overexpressed in several kinds of cancer (compared... Read More

Dual Axes Confocal Microscope for In Vivo Vertical Cross-Sectional Imaging

4307 – Epithelial cancers known as melanomas account for 90% of cancers globally. In most cases, diagnosis is conducted by biopsy which happens by endoscopy for cancers in the gastrointestinal tract. The earlier that diagnosis occurs, the better the prognosis and the less invasive the therapies that may be used. Alternatives to biopsy include microendoscopy which may allow for monitoring and... Read More

Biomarker for Chronic Diarrhea Associated with Irritable Bowel Syndrome

4920 – Irritable bowel syndrome (IBS) is a functional disorder of the intestine affecting the normal motility. IBS is characterized by abdominal pain and altered bowel habits in the absence of an obvious pathology. Based on bowel patterns, IBS can be subtyped into IBS-D (diarrhea predominant) or IBS-C (constipation predominant). Due to the limited knowledge about IBS pathogenesis, there is currently... Read More

Opioid Peptidomimetics with Improved Therapeutic Profiles

5395 – Pain affects nearly 60 million Americans annually, with chronic pain afflicting over 32 million Americans. Opioids, specifically agonists of the Mu-opioid receptor (MOR) are considered to be the most potent therapeutic available for managing chronic pain, although they carry serious risks including the potential for addiction and tolerance to the opioid. Tolerance results in an ever... Read More

High Output Fistula Management System

4258 – In the U.S. 1 in every 3000 people are diagnosed with some form of autoimmune disorder affecting the gastrointestinal (GI) tract. Of these patients a significant portion of them will develop further complications, either from the disease or from surgery, that result in a rupture of their GI tract allowing the contents of the stomach or intestines to leak out. This abnormal opening... Read More

Molecular Cloning of Orphanin FQ Receptor Gene and Differential Tissue Expression of Splice Variants

2060 – Functional gastrointestinal (GI) and motility disorders affect millions of people of all ages, but presently few treatments are able to restore function. More than 50% of patients undergoing abdominal surgery suffer from post-operative ileus, which currently has no effective treatment. The investigators have demonstrated that Orphanin FQ (OFQ), a neruropeptide, in gastrointestinal... Read More

Methods of Treating Intestinal Disorders

1542 – Post-operative ileus is a common clinical problem for which there is no effective treatment. Following an operation, gastrointestinal motor failure ensues for several days; food and fluids are not tolerated, and no flatus or stool is passed per rectum. Analogues human studies confirm that the colon is slowest to recover. Furthermore, motility patterns do not return entirely to normal as... Read More