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Cerebral Blood Flow Monitor for Continuous, Real-time Monitoring of Traumatic Brain Injury (TBI)
2018-471 – Traumatic and other brain injuries are often followed by secondary ischemic damage to the brain that results from decreased blood flow. As high intracranial pressure (ICP) is often the cause of the decreased blood flow, ventriculostomy catheters and intraparenchymal monitors have been employed to measure ICP. However, there are no reliable methods for directly monitoring cerebral blood... Read More
The DICE Approach
7564 – Additional Information coming soon!
Artificial muscle peripheral nerve repair tool kit for treating neuromas
5871 – This technology uses electrical stimulation and a tissue engineered artificial muscle derived from the patient to treatment neuromas (painful nerve growths). This reduces the pain experienced by the patient. Neuromas are often result from the nerves left behind after a limb amputation. About 1.7 million limb amputees are present in the US. About 75% of limb amputees have report severe limb... Read More
Corticocardiac Coupling as a Risk Factor for Sudden Death
6687 – Sudden death occurs in more than 400,000 Americans annually and is a significant and under-recognized consequence of stroke. Identification of patients at risk for sudden death after stroke poses a major challenge. Recently, an animal model of stroke uncovered a surge in synchronous brain and heart electrical activity (corticocardiac coupling) hours before sudden death. This finding was... Read More
Fiberless Optoelectrodes for Multicolor Neural Stimulation
6575 – Optogenetics is a relatively new technology in the field of neuroscience that combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within a neural circuit. Neurons now may be controlled with optogenetics for fast, specific excitation or inhibition within systems as complex as freely moving mammals. Optogenetics is based on... Read More
Monolithically-Integrated Micro-LEDs on Silicon Substrate for Implantable Neural Probes
6277 – Implantable neural probes with monolithically-integrated micro-LEDs on silicon substrates have been demonstrated at the University of Michigan. Monitoring how neural circuits work together and perform computational processing is critical to the understanding of brain function and behavior. Through optogenetics, photosensitive ion channel proteins called opsins can be introduced into specific... Read More
Online concussion education for parents and coaches
6751 – Cerebral concussions are notoriously difficult for sports medicine teams to evaluate and manage. These “invisible injuries” are often difficult to diagnose, but have the potential to lead to severe long-term health conditions, such as postconcussion syndrome and chronic traumatic encephalopathy. Determination of when it is safe for an athlete to return-to-play can help prevent further injury.... Read More
Coherence-Based Sleep Analysis (CobSA)
6321 – Sleep disorders such as insomnia and sleep apnea affect around 50-70 million people in the United States. Lack of sufficient sleep and rest are directly linked to increased incidence of motor crashes, occupational accidents and industrial and medical disasters. Sleep disorders are often diagnosed using polysomnograms, where a patient is monitored during their sleep for changes in brain wave... Read More
Automated Detector and Classifier of High Frequency Oscillations
6344 – Epilepsy is one of the most frequent neurological diseases with an overall incidence between 0.5 and 1%. The most promising treatment is the surgical removal of the epileptogenic zone (EZ). Patients however can only profit from this type of treatment if seizures are generated over a well-localized area and if this area can be removed safely. There is still a major challenge in treating... Read More
Polycolonal antibodies for various species of fluorescent proteins
6416 – With billions of neurons connected by trillions of synapses, the brain is by far the most intricate and complex organ. A complete map of the brain’s connections will be essential to understanding its function. Some of the tools that have been invaluable towards creating this map are the colorful range of fluorescent proteins used to label individual neurons and subcellular structures. ... Read More
Method for Amplifying Signals from Individual Nerve Fascicles to Above 250 uVpp
6457 – Monitoring neurological physiology Monitoring and measuring neurological activity is critical to the diagnosis and treatment of neurological disorders, pain management, and the control of prosthesis. The human nerve fiber has a complex geometry, emits small signals, and reacts poorly to direct electrical wire measurement, which makes it difficult to record data directly. Cuff electrodes can... Read More
Novel therapeutic method involving Down syndrome cell adhesion molecule (Dscam) to treat neurological and mental disorders
5991 – Dysregulation of Down syndrome cell adhesion molecule (Dscam) expression has been implicated in many neurological and mental disorders including Down syndrome, Fragile X syndrome, bipolar disorder and intractable epilepsy. Particularly, increased Dscam protein levels have been found to induce overgrowth of axon terminals in developing neurons, which is a major contributor to the pathogenesis... Read More
Opioid Peptidomimetics with Improved Therapeutic Profiles
5395 – Pain affects nearly 60 million Americans annually, with chronic pain afflicting over 32 million Americans. Opioids, specifically agonists of the Mu-opioid receptor (MOR) are considered to be the most potent therapeutic available for managing chronic pain, although they carry serious risks including the potential for addiction and tolerance to the opioid. Tolerance results in an ever... Read More
Personalized non-invasive device to treat tinnitus
5507 – Tinnitus, commonly known as ringing in the ears, affects approximately 50 million people in the U.S. alone, with a particularly high prevalence noted in the aging population. Moreover, tinnitus is the most common disability among U.S. military veterans, for whom estimated associated costs exceed $2 billion annually. In a substantial number of tinnitus cases, symptoms can be severe to... Read More
Focused Transcranial Magnetic Stimulation with Metamaterial
5079 – In the next few decades one-third of the U.S. population will suffer from a neurodegenerative disorder. These disorders will overtake cancer as the second top killer of Americans. Diseases such as Parkinson’s and Alzheimer’s are debilitating and are currently managed through brain surgery and medication. Neurostimulation has shown significant improvements in the quality of life and... Read More
A Novel microRNA that Regulates Neural Differentiation of Stem Cells
4547 – MicroRNAs are small, non-coding RNAs that regulate expression of their target genes by controlling transcription and/or translation. Thus, microRNAs provide a mode of regulating cell differentiation. Previous studies have shown that forced expression of the early neural inducer, noggin, promoted proliferation and neuronal differentiation of subventricular zone (SVZ) neural progenitors and... Read More
Thermal Stabilization of Cocaine Esterase
4512 – Cocaine is considered to be the most addictive of all substances of abuse. Estimates for 2006 suggest that over half of all illicit drug-based emergency department visits involved cocaine, with over 500,000 occurrences. The devastating medical and social cost of cocaine addiction and overdose make discovery of pharmacological agents to block the addictive effects of cocaine an important... Read More
Regulation of Macrophage Trafficking in the Ischemic Brain
3903 – Blood vessels possess certain properties that enable them to maintain free flow of nutritive blood, oxygen, fluids, and dissolved substances to tissues. Among the properties regulated by the blood vessels, are those that control coagulation, vasodilation, inflammation, proliferation, and barrier function. In this regard, dissipation of nucleotide phosphates, including ATP, ADP, or AMP,... Read More
Scaffoldless Three-Dimensional Engineering Nerve
4411 – Nerve grafts are often required to replace tissue damaged by disease, surgery, or extensive trauma. The current “gold standard” for repairing transected nerves in the peripheral nervous system is an autologous nerve graft. However, there are several concerns that arise with nerve grafting such as harvesting the donor nerve graft can lead to donor site neuroma, loss of function, and... Read More
Treatment of Demyelinating CNS Disease
4276 – Demyelinating disease such as multiple sclerosis affects the nervous system, where the neuron myelin sheath is damaged. Such disease may be caused by various factors including genetics, infectious or chemical agents, or autoimmune responses. Multiple sclerosis is one of the most common demyelinating disease whereby the patient’s own immune system attacks and damages the myelin sheath, and... Read More
Methods and Reagents for Activating Heat Shock Protein 70
3306 – Huntington’s disease is an inherited progressive form of dementia that affects motility, personality and memory as the disease advances. Huntington’s affects about 30,000 Americans with a prevalence of 1 in every 10,000 people. The prevalence of the disease is between 3-7 per 100,000 in populations of Western European decent. Huntington’s is a genetic disease with an autosomal dominant... Read More
Schizophrenia Gene #1 - Two Mutations
3076 – Schizophrenia affects ~ 1% of Americans. Diagnosis of schizophrenia and other neuropsychiatric disorders currently relies on behavorial symptoms, such as massive disruption of thinking, mood and overall behavior. Researchers at the University of Michigan have identified markers for neuropsychiatric disorders. In particular, they have studied genetically susceptible regions for... Read More
Disturbance in the Neuropathy Target Esterase Pathway Causes Degenerative Neurologic Disease
2611 – Motor neuron disorders include amyotrophic lateral sclerosis, autosomal recessive spastic paraplegia, hereditary spastic paraplegia, primary lateral sclerosis, progressive pseudobulbar palsy, progressive muscular atrophy, progressive bulbar palsy, and postpolio syndrome. Symptoms characteristic for a specific type of motor neuron disorder vary according to the part of the nervous system... Read More
Delivery System for Treatment of Brain (or other organs) Diseases/Disorders
2496 – One of the challenges in the administration of anticancer therapeutics is the targeted delivery of the therapeutic to the tumor cells in a specific and exclusive manner. As most anticancer agents strongly interfere with replication and other cellular functions, and are often cytotoxic, nonspecific delivery of these agents to noncancerous cells leads to serious toxic side effects. In... Read More
Noninvasive Nonlinear Method for Seizure Prediction
2377 – Epilepsy affects approximately 2.5 million individuals in the US, with about 150,000-200,000 new cases diagnosed per year. In approximately 75% of affected individuals, the epilepsy has no identifiable cause. An epileptic incident is characterized by intermittent interruption of normal brain function by sudden and often intense periods of synchronous neural discharge, resulting in either... Read More
Inhibitors of RGS Proteins
2157 – RGS proteins represent a novel family of proteins that regulate the activity of G protein and G protein-coupled receptors. There are over twenty members of this protein family, and it continues to grow as new members are discovered. The primary action of RGS proteins is to speed the deactivation of G proteins thus inhibiting G protein signaling. G protein-coupled receptors are involved in... Read More
Treatment of Dopamine-Related Diseases (Parkinson’s, Schizophrenia, Depression, Drug Abuse) through Selective Ligands for Dopamine 3 Receptor
4080 – These dopamine 3 (D3) ligands have therapeutic potential for the treatment of dopamine-related diseases like Parkinson’s, depression, drug addiction, schizophrenia, and restless leg syndrome. The D3 agonists are designed to bind selectively to the D3 receptor subtype to partially or fully modulate the receptor, correcting for an excess or deficiency of dopamine. Dopamine is a... Read More