Office of Technology Transfer – University of Michigan
51-100 of 516 technologies within Life Science RSS ATOM

A Genetically Encoded Activator and Controller of the Mitotic Checkpoint

6745 – Spontaneous abortion or miscarriage is a pregnancy that is not viable or in which the fetus is born before the 20th week of pregnancy. Spontaneous abortions occur in 15-20% of recognized pregnancies, with 1% of women having 3 or more consecutive miscarriages. Female fertility is decreased with advanced maternal age, with the risk of miscarriages increasing up to 75% among women aged over 40... Read More

The Landscape of Antisense Gene Expression in Human Cancers

6287 – The human genome is widely transcribed, containing protein-coding and non-coding regions. Double-stranded DNA is transcribed to sense transcripts that are eventually translated to form proteins. Some DNA is transcribed into natural antisense RNA (NAT), which are endogenous transcripts that are complementary to sense transcripts. NATs are widespread in eukaryotes with complementary to sense... Read More

An automated high-throughput method for identifying long non-coding RNAs associated with cancer

6286 – Cancer is the second leading cause of death in the United States. While recent efforts at analyzing the transcriptome of cancer patients have focused on studying protein-encoding genes, several long non-coding RNA (lncRNA) transcriptions have been found to promote oncogenesis. Previous attempts at identifying these cancer-associated lncRNAs have been limited. The evolution of high-throughput... Read More

PIEZOELECTRIC BEAM ENERGY HARVESTER WITH TIP MASS FOR LEADLESS PACEMAKER

MRI Compatible Piezoelectric MEMS Energy Harvester with Tip Mass for Leadless Pacemaker for Heartbeat Vibrations

6782 – Energy harvesting devices and their unique ability to convert the ambient energy into electrical energy has attracted much interest in industrial and manufacturing sectors. Vibration is one of the common sources in energy harvesting and a widely used method of converting vibration into the electricity is by using the piezoelectric materials. One important application of such piezoelectric... Read More

Algorithm to Identify Patients with Hepatocellular Carcinoma

5396 – Predictive Modeling for Assessing Patient Risk for HCC Researchers in the Department of Statistics and Doctors at the University of Michigan Hospital had developed a machine learning algorithm that predicts the presence of HCC in patients. The predictive model uses results from standard laboratory tests as predictors of HCC. In a clinical trial from 2004 to 2010, the team demonstrated... Read More

Glucagon-like Peptide-1 Fusion Protein for Treating Diabetes and Cardiovascular Diseases

6539 – The prevalence of type 2 diabetes is growing in the United States and around the world. The disease afflicts an estimated 504 million individuals globally, including 20.9 million Americans. Because of its characteristic insulin resistance, type 2 diabetes not only leads to short-term problems with glucose uptake, but it can also lead to long-term complications including other metabolic... Read More

Online concussion education for parents and coaches

6751 – Cerebral concussions are notoriously difficult for sports medicine teams to evaluate and manage. These “invisible injuries” are often difficult to diagnose, but have the potential to lead to severe long-term health conditions, such as postconcussion syndrome and chronic traumatic encephalopathy. Determination of when it is safe for an athlete to return-to-play can help prevent further injury.... Read More

Novel Acinetobacter baumannii biofilm inhibitors

6671 – Acinetobacter baumannii are opportunistic pathogens that are frequently associated with hospital acquired infections. Multi-drug resistant strains are not uncommon and even pan-resistant strains have been identified. This antibiotic resistance appears to be mediated through the formation of biofilms. Biofilms are formed through a highly structured extracellular polymeric matrix which... Read More

Peptidomimetic Compounds for Arthritis and Bone Erosion Treatment

6657 – Rheumatoid Arthritis (RA) affects 50 million people worldwide. Available therapeutic options focus on treating symptoms but do little to slow disease progression. This is primarily due to the mechanism of action of current medications which are not specific to the pathogenesis of RA. Biologics targeting inflammatory cytokines currently dominate the market and provide relief to many. However,... Read More

Fiber optic Raman spectroscopy probe with hollow insertion system

6392 – Fiber optic Raman fluorescence reflectance spectroscopy probe Calciphylaxis is a painful and debilitating condition that creates large open wounds most frequently in patients with renal failure. Calciphylactic lesions are characterized by the precipitation of calcium deposits in the skin and soft tissues, which results in vessel thrombosis and tissue necrosis. Diagnosis of calciphylaxis... Read More

Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof

5475 – Blood clotting and formation of fibrous connective tissue are important biological functions that require tight regulation because either excess or insufficient formation of blood clot or connective tissue can lead to devastating health conditions. Plasminogen activator inhibitor-1 (PAI-1) is the critical molecule that modulates both of these biological processes. Although cases of... Read More

Injectable and Self-integrating Hydrogels

5933 – Injectable hydrogels that can encapsulate pharmaceuticals or regenerative cells allow for the delivery of active biological species directly to a target area. These materials have potential to aid in next generation drug delivery and tissue engineering procedures such as the sustained release of hormonal medication or less invasive tissue regeneration techniques. Biocompatible hydrogels... Read More

Magnetoelastic Actuator for Glaucoma Drainage Devices (MA-GDD)

6680 – The use of glaucoma drainage implants has increased in recent years, especially relative to other surgical glaucoma procedures such as trabeculectomy. The increased utilization of drainage implants is related to a greater experience and appreciation of the efficacy of aqueous shunts, and a growing concern about late complications associated with standard filtering surgery. Glaucoma drainage... Read More

Software for Identification of Common Protein-Protein Interfaces with Applications to Viral Inhibitors and Vaccines

6496 – Interactions between proteins are ubiquitous in biology and have recently garnered much attention from the drug discovery and protein engineering community. Although evidence suggests about 80% of proteins exists in one or more protein complexes during their lifetimes, relatively little is known about the structural evolution of protein interfaces and how they can be exploited as drug... Read More

G protein-coupled receptor kinase inhibitors to treat heart failure

6497 – Heart failure (also known as congestive heart failure) occurs when the heart becomes too weak to pump enough blood to meet the body’s oxygen requirements. In the United States, over 5 million people have heart failure, and the disease contributes to approximately 260,000 deaths (one in every nine deaths total) annually. In addition, heart failure costs the country an estimated $32 billion... Read More

beta1/Contactin Cell Line

mta2585 – beta1/Contactin Cell Line

Discovery of novel (quinolin-8-yl) nicotinamides for pancreatic cancer

6694 – Pancreatic cancer has a 5-year survival rate under 5% and is the deadliest cancer. Early- stage disease is asymptomatic, therefore, advanced late-stage disease is more frequently diagnosed. Pancreatic cancer typically shows resistance to chemotherapy and other therapeutics resulting in poor prognosis. Some patients are eligible for surgery but relapse often arises. In addition, 80% of... Read More

Methods for Converting Stem Cells Into 3D Lung Tissues Through Directed Differentiation

6573 – Currently, there is a challenge in studying organ development and organ diseases. In vivo animal models are time consuming, difficult to study, and often don’t directly mimic a human organ system. Therefore, there has been a drive to create an in vitro model that better resembles a human system. Scientists have been able to drive human pluripotent stem cells (hPSCs) in to specific organ cell... Read More

Multimodal Imaging in Retinal Diseases

6593 – The clinical evaluation of blinding retinal diseases such as Inherited Retinal Degenerations, Diabetes, Age Related Macular Degeneration (AMD) and Glaucoma necessitates integration of clinical data obtained from various modalities. Macular degeneration is the leading cause of vision loss in Americans 60 years of age and older. As many as 11 million people in the United States have some form... Read More

Generation of Ag18F and its use in the synthesis of PET radiotracers

6465 – UM File # 6465 Background Technology Description Applications Advantagesission tomography (PET) is an imaging technique that relies on the decay of radioactive elements within a small molecule probe to produce an image of the spatial distribution of the probe in diseased tissues. Despite its promising applications in fields like oncology, neurology, and cardiology; PET has seen limited... Read More

Schematic of Brain Computer-Interface for Multiple Choice Testing

Direct Brain-Computer Interface for Cognitive Assessment

6101 – In many case individuals with neurological conditions such as ALS or traumatic brain injuries do not have motor and verbal control required to communicate using typical methods. When cognitive assessments are used to measure cognitive abilities which can be used to determine therapies and services, the assessments are inaccessible to these patients because they cannot select answers. ... Read More

CARD-024 Amelioration of Intestinal Fibrosis and Use for Treatment of Crohn's Disease

5383 – Crohn’s disease is a chronic inflammatory bowel disease in which there are periods of inflammation of the gastrointestinal lining followed by periods of mucosal healing. There is no cure for Chron’s and it affects roughly 200 out of every 100,000 adults. Though Chron’s can be managed with anti-inflammatory therapies and immune system suppressors, nearly 70% of patients develop excessive scar... Read More

Combined Scintillator-based Neutron and Gamma-ray Dosimeter

6379 – Radiation dosimeters are used to measure exposure to ionizing radiation (such as gamma rays and neutron). These instruments are used to determine radiation exposure in research and medical facilities, security checks (e.g. in the airport), food and other industries where radiation is used as a sterilization tool. The global market for dosimeters was worth ~$6000 million in 2012 with an... Read More

Metamaterial Sensor Platforms for Terahertz DNA Sensing

6246 – Terahertz sensors are a promising technology for studying DNA hybridization due to the distinctive refractive response differences between single-strand and double-strand DNA polynucleotides. This inherent difference opens the door to highly sensitive label-free detection and identification of DNA sequences. A new sensing platform now promises to greatly increase the sensitivity of DNA... Read More

A Catheter and Method for Cardiac Intracavitary Mapping and Navigation

5848 – This is an intracardiac mapping catheter that can be used in cardiac electrophysiology studies to guide catheter ablation for treating cardiac arrhythmias. It is a non-contact mapping system that detects movement of the blood inside a heart chamber and uses that information to localize the source of fibrillation in the heart wall. Atrial fibrillation is the most common type of arrhythmia that... Read More

Algorithm and Device to Detect and Differentiate AF from Other Arrythmias

4633 – In an embodiment, an apparatus for detecting arrhythmias within a body, the apparatus includes: an input stage to receive an electrocardiogram signal from a body connected thereto through a detection electrode input, wherein the input stage is a real-time dynamically adjustable signal transformation stage configured to condition the electrocardiogram signal; an analysis stage coupled to the... Read More

Overnight Corneal Reshaping - Quality of Life (OCRQOL) Questionnaire

6529 – Over half of all Americans use corrective eyewear such as glasses and contact lenses. When choosing corrective eyewear, doctors are concerned with safety, efficacy, visual acuity, and complication rates, while patients typically consider how different options affect their vision-related quality of life. All of these factors must be considered to find an ideal treatment. An important method... Read More

Image Processing and Machine Learning for Diagnostic Analysis of Microcirculation

6516 – One of the major causes of death worldwide is coronary artery disease, for which stent implantation is a common treatment. Current diagnosis of coronary artery disease relies on visual examination of angiograms by operators to identify significant stenoses in arteries. Visual examination of angiograms might lead to false diagnosis as it relies on estimation, which is subject to intra- and... Read More

Distance-Preserving Penalty Function for Imposing Local Rigidity in Deformable Image Registration

6374 – One of the most popular diagnostics for oncology imaging is computed tomography (CT). Worldwide, the CT market accounts for 17.0 per cent of the total diagnostic medical imaging industry. As CT technology improves, physicians are able to use these tools for better approaches to patient treatment. Radiation therapy is a commonly used treatment for many types of cancers, especially in the... Read More

Machine Learning for Hepatitis C

6348 – This technology provides a novel method for the prognosis of Hepatitis C progression. Hepatitis C is often chronic, and of those with chronic Hepatitis C, ~65% eventually develop chronic liver disease, and ~15% develop cirrhosis which is often a precursor for liver cancer. It is currently difficult to predict which individuals will develop complications from chronic Hepatitis C infection. ... Read More

ECG Characteristics Prior to In-Hospital Cardiac Arrest

6434 – This technology defines a set of ECG features for predicting the onset of cardiac arrest. In-Hospital Cardiac Arrest (I-HCA) effects some 200,000 people yearly, and has a survival rate under 30%. Despite the fact that some ECG patterns are known to be associated with cardiac arrest, there are no reliable tools to predict its onset. This technology predicts cardiac arrests before they occur... Read More

Electrocardiogram Data Analysis Method For Rapid Diagnosis

6257 – With an expected market size of over US$4 billion, electrocardiograms are the most utilized diagnostic tool in the medical field and are generating huge amount of data. Dealing with these data requires efficient data management systems, signal processing, and data analysis methods. To meet these needs, the data management system market has been growing steadily in the developed world and is... Read More

High-Confidence Single-Molecule Detection of RNA Biomarkers

6250 – Rapid, Amplification- and Label-Free, Ultrahigh-Confidence Counting of Single RNA and Other Biomarker Molecules in Patient Samples MicroRNAs (miRNAs) and other non-coding RNAs (ncRNAs) have recently emerged as promising diagnostic biomarkers for virtually all pathologies, including cancer, heart disease, diabetes, Alzheimer’s, and viral infection. We have developed a novel technology... Read More

Novel method for assessment and prediction of cardiovascular status using signal processing and machine learning

6215 – Cardiac arrest accounts for over 15% of all deaths in Western countries. Cardiac arrest is caused by abrupt loss of heart function leading to cardiac dysrhythmia. Some cases of cardiac arrest such as such as ventricular fibrillation are treatable with CPR (cardiopulmonary resuscitation) and immediate defibrillation. However chances of successful defibrillation deteriorates over time and with... Read More

Novel method to obtain mature human stem cell derived cardiovascular cells for drug discovery and therapeutic applications

6203 – UM File # 6203 Background Technology Description Applications Advantagesare revolutionizing the drug discovery and development process used by pharmaceutical companies to identify lead drug candidates that provide opportunities to build innovative cellular models. Induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to an embryonic stem cell. The... Read More

Methods and Apparatus for Optimizing Therapeutic Temperature Control

6114 – Described here are the methods and designed apparatus for optimized therapeutic control for clinical use. Therapeutic hypothermia is now a well-developed technique used in certain surgeries where blood flow to the brain may be jeopardized or in the care of the victim of cardiac arrest. In both settings, this is done to help preserve or improve neurologic function. Hypothermia can be induced... Read More

Fully Implantable MEMS-based Piezoelectric Cochlear Implant with Flexible Spring-mass Design

6090 – The FDA has reported that at the end of December in 2012, more than 324,000 people worldwide had received cochlear implants (CIs), and this number is expected to grow in coming years due to hearing loss in the aging population. The global market for hearing implants was valued at $960M in 2010 and is expected to grow to $2.3B by 2017. Cochlear implants transduce vibrations in the ear into... Read More

Pharmacogenomic response and prognosis software without disease specificity

6337 – This technology predicts outcomes of pharmaceutical use based on data from previous patients to identify the best course of action, the major goal of pharmacogenomics. Many classes of disease have large percentages of patients who do not respond to medications, represented wasted time, money, and patient wellness. Understanding pharmacogenomics will help save tens of millions of dollars in... Read More

Renal Risk Index Calculator

6460 – The Renal Risk Index (RRI) uses patient qualities after transplant to predict the possibility of End-Stage Renal Failure (ESRD) in patients. ESRD affects 339 people per million, and can be caused by poor recipient response to liver transplantation. However, predicting which patients are most at risk for ESRD after liver transplantation is a difficult task. The RRI is a powerful measure of... Read More

Continuous Non-Invasicce Blood Pressure Monitor to Maintain Permissive Hypotension

Non-invasive Blood Pressure Monitor for Permissive Hypotension in Critical Care

5907 – Permissive hypotension in pre-hospital and critical care environments helps prevent re-bleeding from severe injuries. Continuous non-invasive blood pressure monitoring is essential in maintaining permissive hypotension, but is challenging in the pre-hospital setting. However, invasive methods pose risks such as infections. Researchers at the University of Michigan have developed a technology... Read More

Intelligent respiratory ventilator monitoring and controller system

5894 – Ventilators mechanically assist the flow of air into the lungs of patients unable to breathe on their own due to acute lung injuries, respiratory failures, cardiovascular and brain injuries etc. It is estimated that ~2.7 episodes of mechanical ventilation occur per 1000 population units, and is often a lengthy and expensive process. Currently, important decisions regarding mode and duration... Read More

Coherence-Based Sleep Analysis (CobSA)

6321 – Sleep disorders such as insomnia and sleep apnea affect around 50-70 million people in the United States. Lack of sufficient sleep and rest are directly linked to increased incidence of motor crashes, occupational accidents and industrial and medical disasters. Sleep disorders are often diagnosed using polysomnograms, where a patient is monitored during their sleep for changes in brain wave... Read More

Automated Detector and Classifier of High Frequency Oscillations

6344 – Epilepsy is one of the most frequent neurological diseases with an overall incidence between 0.5 and 1%. The most promising treatment is the surgical removal of the epileptogenic zone (EZ). Patients however can only profit from this type of treatment if seizures are generated over a well-localized area and if this area can be removed safely. There is still a major challenge in treating... Read More

Method for the Automated Measurement of Changes in Retinal Disease

5867 – This technology is a computer program that automatically detects and quantifies subtle changes in disease markers present in the human retina, resulting from diseases such as age-related macular degeneration (AMD) or diabetic retinopathy (DR). Current imaging methods to monitor and diagnose retinal diseases include fundus autoflourescence (FAF), fluorescein angiography (FA), indocyanine... Read More

Microfluidic Device for Capture and Release of Rare Cells

6590 – This technology describes a new microfluidic device which utilizes a blend film of graphene oxide (GO) sheets and thermally responsive polymers to enable efficient cell capture and release, including circulating tumor cells (CTCs). Current microfluidics-based CTC isolation technologies are capable of isolating, enumerating and characterizing CTCs, however, CTC release after selective... Read More

Production and Engineering of Enveloped Influenza Virus-Like Particles in yeast cells.

6531 – Influenza is a contagious, widespread viral infection that affects the respiratory system. Influenza affects nearly 5 million people and causes 250,000 to 500,000 deaths annually. The virus mutates rapidly, making it difficult to produce a long-term vaccination and therefore an annual vaccination must be developed. Currently, influenza vaccines are produced mainly using chicken egg-based... Read More

Polymeric RNA Delivery Systems for Controlled Release

6382 – RNA-based therapeutics is a growing field of research which is expected to continue growth in coming years. Though few therapies have been commercialized to date, the uses of RNA extend to treatments addressing disease, genetic disorders, cancers and regenerative medicine among others. It is expected that by 2020 therapies based on RNA technologies will generate $1.2B in revenue. One... Read More

Luminescent Heteromatallic Metallacrown Complexes for Biological Assays and Imaging

6312 – Sensitized lanthanides are becoming increasingly important across multiple scientific industries because of their stability, long luminescence lifetimes, and narrow emission bands. In the growing field of biological assays there has been demonstrated need for luminescent dyes that emit outside of the visible range where traditional fluorescence measurements suffer from high levels of... Read More

Kirigami Nanocomposites with Improved Elasticity and Conductivity

6621 – Tuning the mechanical and electrical properties of novel composite materials is one of the most challenging problems in materials science today. With the growing popularity of graphene and carbon nanotubes for use in electronics, much effort has gone into developing these technologies. Here, we disclose novel patterning techniques for graphene/PVA nano composites that allow for great... Read More

MyChemoCare Teleconsultation App to Address Chemotherapeutic Symptoms

6271 – This mobile app enhances personal communications between doctors and chemotherapy patients who may be far from their specialist or have difficulty making frequent trips to the in-person consultations by facilitating easy tracking and discussion of symptoms. Telemedicine is a growing market valued at approximately $7.6 billion, aiming to improve healthcare outcomes for remote populations... Read More

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