Office of Technology Transfer – University of Michigan
1-50 of 516 technologies within Life Science RSS ATOM

Identification and Use of Intestinal Resident Bacteria that Mediate Protection Against Enteric Pathogens

7130 – The high susceptibility of neonates to intestinal infections has been assumed to be largely due to immaturity of the immune system, but the mechanism remains unclear. Resident intestinal bacteria provide several benefits to the host. A major function of the gut microbiota is to protect the host against colonization by pathogens; however, the specific group of bacteria that mediates... Read More

A High-throughput Fluorescence Assay for the Determination of Spontaneous Viral Mutation Rates

7383 – The technology disclosed is a Luria-Delbruck fluctuation test for influenza virus mutation rates that scores reversion to fluorescence in a set of 12 mutant green fluorescent proteins (GFP). Globally, seasonal influenza is a major cause of severe respiratory infections, leading to excessive hospitalizations and 1 million deaths/year. The global influenza market (vaccines, antivirals, and... Read More

Generation of a Floxed TERT mouse for conditional analysis of telomerase function

7354 – Telomeres are important for protecting the ends of chromosomal DNA as we age. They progressively shorten over time, but this process may undergo abnormal alteration during disease such as cancer. Telomerase is the enzyme complex responsible for extension of telomeres. More specifically, telomerase reverse transcriptase (TERT) is the catalytic portion of this complex responsible for telomere... Read More

FIZZ1 Knockout Mouse

7353 – FIZZ1 (found in inflammatory zone) is a cysteine rich secreted protein. It is encoded by a gene known as Retnla or Remα. Upon deletion or overexpression of the gene, researchers have found that it has many roles in the regulation of fibrosis, pulmonary allergic inflammation, immune response, tissue remodeling, wound healing, and infection. However, most of the studies to date have been... Read More

Ear splint to correct congenital ear deformities

7199 – Congenital ear deformities such as low grade microtia, lop ear, Stahl ear, cryptotia, or prominotia are fairly common in infants. Currently, there are two ways to treat ear deformities: ear molding and ear surgery. Surgery is costly, and the risks of anesthesia and other complications usually defer surgery until the child reaches six years of age. However, deformities of the ears can lead to... Read More

Hydro-Seq: High Sample Efficiency Single Cell Whole Transcriptome Analysis Technology

7243 – To adequately diagnose and treat cancer, cancer cells are studied for particular gene expressions. Research has shown that the most important cells to look for are circulating tumor cells (CTCs) as these give rise to cancer. Traditional technologies for studying gene expression look at a population average, which masks diversity that is often seen in cancer patients. It is estimated that CTCs... Read More

Development of Amnion-Like Tissue From Human Pluripotent Stem Cells

7115 – The amniotic membrane (AM) forms the inner layer of placenta surrounding a fetus during pregnancy, allowing successful embryonic implantation, providing protection against physical trauma, maintenance of constant temperature, and amniotic fluid flow that assists in musculoskeletal development. Failure of the embryo to implant contributes to loss of pregnancy, which occurs at a rate of 10-12%... Read More

ALT TEXT: Artificial muscle construct for treating neuromas

Artificial muscle peripheral nerve repair tool kit for treating neuromas

5871 – This technology uses electrical stimulation and a tissue engineered artificial muscle derived from the patient to treatment neuromas (painful nerve growths). This reduces the pain experienced by the patient. Neuromas are often result from the nerves left behind after a limb amputation. About 1.7 million limb amputees are present in the US. About 75% of limb amputees have report severe limb... Read More

Inhibitors of Gram-negative bacterial growth, specifically uropathogenic E. coli

7133 – Center for Disease Control (CDC) has declared that one of the biggest public health concerns that we currently face is a gram-negative bacterium. These bacterium cause many diseases and are inherently hard to treat. In addition, these bacterium also adapt quickly and become resistant to most of the available antibacterial/ antibiotic drugs. In urinary tract infections (UTIs), E. coli is often... Read More

Two-Phase Technique to Remove Calcified Plaques and Restore Blood Flow Coupled to A Catheter Temperature Control System in Atherectomy

7229 – The technology disclosed is a novel two-phase atherectomy technique to restore blood flow with minimized cutting force and temperature rise. The method can be used as a safer alternative to existing atherectomy techniques. Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Cardiovascular disease is predominantly cased by atherosclerosis—a condition where... Read More

Tourniquet Optimized for both Civilian and Military Trauma Use

7205 – Tourniquets help save lives by constricting blood flow to a traumatized limb thereby preventing excess blood loss in a medical emergency. Existing tourniquets are primarily designed for use by medical professionals and combat personnel and such as the military and law enforcement agencies. Application of these types of tourniquets can be painful and physically challenging, in part, due to a... Read More

Moisture imaging of wound and burn depth for clinical assessment

6458 – Physicians and surgeons treating wounds and burns perform debridements simply according to how the insult looks. There is no objective or well-accepted method to assess wound depth or other characteristics. Punch biopsies may be used to evaluate wounds, but the procedure may impair restorative processes and cause infection. A single biopsy also does not allow for wound observation at multiple... Read More

A Molecular Adjuvant for Cancer Immunotherapy

6869 – At their most basic, vaccines are comprised of antigens to mount an immune response against, for instance the surface proteins of influenza, and another component (called an adjuvant) to help stimulate the desired immune response against the antigens. Vaccines have been critical to the prevention of infectious disease over the last 100 years, helping to provide protection against diseases... Read More

Prevention and Treatment of Traumatic Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva

6934 – Heterotopic ossification (HO) is a severely debilitating formation of abnormal bone growth resulting from trauma-induced injury to musculoskeletal and central nervous systems, including major burns and orthopedic interventions. Estimated to complicate up to 80% of hip replacements and 20% of spinal cord injuries in the civilian population, HO also affects more than 60% of military personnel... Read More

Scalable Multiplexed Drug-Combination Screening Platform Using 3d Microtumor Model for Precision Medicine

7222 – Drug Combinations have been an advantageous for the treatment of cancer as targeting two pathways can lead to an improvement in efficacy and has been shown to aid in overcoming resistance mechanisms. Clinical trials involving combinational therapies are very costly and time consuming, thus most pharmaceutical companies first assess drug combinations in-vitro. Current screening methods make... Read More

Contact-free nanoscale temperature sensor

7156 – The real-time, high throughput, repeatable, nanoscale mapping of temperature is needed in many areas of industry and public health. However, currently available technologies lack certain features; for example, contact-based methods is a destructive method, and relies on scanning which is inherently slow. Alternatively, optical microscopy-based methods, such as fluorescence microscopy,... Read More

Methods of characterization of cancerous lesions

6907 – Early cancer screening with modern technology has markedly improved the detection of small neoplasms, or abnormal growths, that were previously impossible to identify. However the likelihood that these early detected neoplasms will progress to invasive metastatic cancer is unknown. These abnormalities are often treated as though they will potentially become invasive cancer which forces... Read More

Mood-Enhancing Dynamic Commercial Lighting

6654 – Sleep and mood disorders such as insomnia, jet lag, and seasonal affective disorder (SAD) affect many adults, and are related our sleep/wake cycle, also known as our circadian rhythm. According to a 2011 poll performed by the National Sleep Foundation, as many as 43% of Americans between the ages of 13 and 64 say that they rarely or never get a good night’s sleep on weeknights. In the United... Read More

Clinical Augmented Reality Evaluation of Patient Brain Activation in Real-Time

7010 – Clinical exam doctors investigate a patient’s body for signs of disease or trauma, however when trying to get information about pain or emotional experiences (such as anxiety), the doctor must rely on the patient’s ability to communicate which becomes a problem if the patient cannot communicate verbally or with writing (such as being unconscious or having a mental disability). Measuring... Read More

Mobile app for knee replacement perioperative care

7020 – The number of knee replacement surgeries has almost doubled since 2001, with over 700,000 cases performed in 2011, and are now one of the most costly procedures in the US, with an aggregate cost of over $9 billion in 2008. As The Centers for Medicare and Medicaid Services implement payment models that penalize hospitals for poor outcomes, it has become increasingly important to monitor,... Read More

IMassFrag: Metabolite Identification Software

7009 – IMetabolite identification (MetID) of drug candidates is a critical step in drug discovery and development. MetID can aid medicinal chemists in modifying the metabolic soft spots of a drug candidate in the early stage of drug discovery. Metabolic modification of the compounds may change the pharmacological activity and toxicity of a drug molecule. To reduce the risk of costly... Read More

Respiratory rhythm matrix (RRM), a new method for sleep apnea detection

6918 – Sleep apnea can be defined as a group of disorders characterized by abnormalities of breathing while sleeping. Breathing is interrupted from a few seconds to minutes, occurring several times over the course of a routine sleep. Airway blockage occurs as the patient sleeps. The blockage occurs between the soft palate and/or the back of the tongue and the pharynx. As the patient breathes, the... Read More

Chromosome Breakability Index

6835 – This technology allows researchers to determine how likely a given portion of the genome is to translocate. Genomic translocations occur when one section of the genome is moved to another section of the genome, sometimes disrupting or removing important genetic information. These translocations can lead to diseases, including cancer. Being able to predict where translocations will occur... Read More

Computer Tool for Collaborative Play for Child with Autism Spectrum Disorder

6830 – This technology provides a computer-based medium for patients with Autism Spectrum Disorder (ASD) to interact and learn important tactile skills, all in a fun environment developed with feedback from patients and physicians. With [increasing rates of ASD] (http://www.cdc.gov/ncbddd/autism/data.html), innovative new treatments are needed to address the issue. ASD patients tend to respond... Read More

Computer game tool for physical therapy

6828 – This technology helps patient’s complete physical therapy in fun and engaging ways in the comfort of their own home. A major problem in physical therapy is patient compliance with repetitive tasks. But it’s been shown that videogames can be used to increase compliance and enhance recovery. This technology harnesses these advantages of videogames to create a fun tool to help recovery of... Read More

Corticocardiac Coupling as a Risk Factor for Sudden Death

6687 – Sudden death occurs in more than 400,000 Americans annually and is a significant and under-recognized consequence of stroke. Identification of patients at risk for sudden death after stroke poses a major challenge. Recently, an animal model of stroke uncovered a surge in synchronous brain and heart electrical activity (corticocardiac coupling) hours before sudden death. This finding was... Read More

Fiberless Optoelectrodes for Multicolor Neural Stimulation

6575 – Optogenetics is a relatively new technology in the field of neuroscience that combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within a neural circuit. Neurons now may be controlled with optogenetics for fast, specific excitation or inhibition within systems as complex as freely moving mammals. Optogenetics is based on... Read More

Monolithically-Integrated Micro-LEDs on Silicon Substrate for Implantable Neural Probes

6277 – Implantable neural probes with monolithically-integrated micro-LEDs on silicon substrates have been demonstrated at the University of Michigan. Monitoring how neural circuits work together and perform computational processing is critical to the understanding of brain function and behavior. Through optogenetics, photosensitive ion channel proteins called opsins can be introduced into specific... Read More

F3: Female Foley Facilitator

6643 – Foley catheters are soft, plastic or rubber tubes that are placed transurethrally into the bladder to provide continuous drainage and relief when there is urinary retention, to monitor urine output for critically ill patients, to manage urination during surgery, and to provide end-of-life care. However, these indwelling catheter’s can increase the patient’s risk of death due to urinary... Read More

Automated Analysis of Optic Disk in Retinal Autofluorescence Images

6530 – Fundus autofluorescence (FAF) imaging has proven a versatile method for non-invasive imaging of the retina. Information gained from this method is able to diagnose and monitor multiple diseases of the eye, including age-related macular degeneration (AMD), which affects over 5 million individuals worldwide. Retinal diseases are known to manifest during the later stages of life and the market... Read More

Imaging Assisted Minimally Invasive Implant Surgery

6686 – It is estimated that nearly 2 to 4 million dental implants will be placed in the US by 2020, which will be almost doubled from 2010. This number could significantly increase if minimally invasive surgery (MIS), such as flapless surgery, becomes a routine procedure because it can further increase patient acceptance to implant therapy by reducing surgical time, post-operational discomfort... Read More

A Microscale Whole Blood Coagulation Assay Platform

6536 – The properties of blood clotting in an important medical indicator for identifying blood coagulation diseases, managing hemostatic therapies, and identifying hemorrhage causes and risks during surgery. However, current testing methods are either thorough but lab-based and time consuming, or available at the point-of-care (POC) but limited in capability. A new whole blood coagulation... Read More

Effects on the Controlled Release of Proteins

2865 – UM File # 2865 Background Injectable biodegradable polymeric particles (usually microspheres) represent an exciting approach to control the release of vaccine antigens to reduce the number of doses in the immunization schedule and optimize the desired immune response via selective targeting of antigen to antigen presenting cells. After the first couple of decades of their study, much... Read More

Photo-Acoustic Tomography, PAT contrast agent, Rheumatoid Arthritis, Clofazimine

6731 – Rheumatoid arthritis (RA) is the inflammation of the lining of the membranes that surround your joints which can eventually destroy the cartilage and bone within the joint. The number of people globally with RA was 73 million in 2014. Macrophages are central to the pathophysiology of arthritic inflammation and are at the origin of pathological bone erosion in arthritic conditions. Current... Read More

Use of compound GSK2606414 for the prevention of lung inflammation

6785 – Respiratory syncytial virus (RSV) is a respiratory virus that infects the lung and respiratory tract and is a major cause of lower respiratory tract infections in young children and infants. RSV is extremely common and contagious, with nearly all children being infected with RSV by age two. Usually RSV results in mild cold-like symptoms in adults and healthy children, but in some patients,... Read More

Dip-coating mediated mammalian cell lyopreservation at ambient temperatures

6849 – Cell-based manufacturing is a major source of protein therapeutics worth over $200 billion worldwide each year. Mammalian cell lines, such as Chinese Hamster Ovary (CHO), are particularly important due to their biological closeness to human cells, but face greater challenges than bacteria or yeast when it comes to storage and transportation. Current methods call for cryopreservation, which is... Read More

Angiogenic Nanotechnologies for Bone Repair and Regeneration

6834 – Bone fractures are a common and costly medical problem in the United States. It is estimated that approximately 6 million Americans experience fractures annually, and 10% of those fractures will result in impaired healing. When a fracture occurs, the initial healing response is highly dependent on functional blood vessels. These blood vessels are necessary in order to supply the fracture site... Read More

Discover KLF14 as a Key Mediator for HDL Metabolism and Identify a KLF14 Activator for the Treatment of Coronary Heart Disease

5698 – UM File # 5698 Background Technology Description Applications Advantagespeutic target for increasing apolipoprotein A1 (apoA1) and high densilty lipoprotein (HDL) for treatment of cardiovascular disease Levels of high density lipoprotein (HDL), commonly referred to as good cholesterol, is inversely correlated with cardiovascular disease (CVD). Apolipoprotein A1 (ApoA1) is the major... Read More

High-Density Genotyping Panel for Genetic Analysis of Outbred Rats

6945 – The laboratory rat serves an important role as an animal model in biological research including the fields of psychology, medicine and new drug development. Many labs utilize congenic rat strains for their research, but studies done in certain fields require outbred strains of rats and mice to be used. One example is in the field of genetics for quantitative trait locus mapping where small... Read More

In-home physical therapy tool for Brachial plexus palsy using Physically Assistive Therapy for Hands (PATH)

6518 – In-home physical therapy represents 90% of all outpatient rehabilitation spending. Despite of high demand and frequent use, in-home physical therapy gets delivered in one of the most outdated and least reliable way; prescription of therapeutic movements as diagrams on a piece of paper relaying 100% on patients' motivation to stick to the exercise regimen. This poses a significant challenge to... Read More

Targeted absolute quantitative proteomics assay

6740 – The rapidly expanding field of proteomics is changing the way we understand cellular function, and paving the path for new diagnostics and medicines each day. The proteomics industry is projected to expand at a rate of 19% per year to a market value of approximately $12B by 2019, making it one of the fastest growing scientific markets in the world. As the medical and pharmaceutical fields... Read More

3D MEMS Scanner for Real-Time Cross-Sectional Endomicroscopy

6867 – Endoscopic procedures are commonly performed for screening cancers originating in the epithelium of the body, such as the colon, esophagus, stomach, lung, bladder, and pancreas. Confocal endomicroscopy is a way to conduct an “optical biopsy” by taking histology-like images of the tissue of interest without the risk and complications of a traditional biopsy. This non-invasive technique is... Read More

Applications of novel ErbB2 selective peptides

6579 – The membrane receptor ErbB2 (also known as HER2/neu) is a member of the epidermal growth factor receptor (EGFR) family. ErbB2 is amplified and overexpressed in many epithelial-derived malignancies including breast, ovarian, and lung cancers. Agents capable of selectively targeting ErbB2 can be used for diagnostics, prognostic indications, imaging and therapeutic applications. The... Read More

Biodegradable Hydrogel using Ultrasound for Tissue Expansion

6749 – Tissue Expansion A material or device designed to induce skin or tissue expansion for the purpose of reconstructive and plastic surgeries has been deemed as a tissue expander. Tissue expanders are temporary inflatable implants that are positioned under the skin to facilitate the increase of tissue dimensions for reconstruction. For instance, inflatable balloons were used for skin expansion.... Read More

A multiple-task spray cap for chromoendoscopy

6675 – Chromoendoscopy is a medical procedure where stains or dyes are applied topically at the time of endoscopy to enhance tissue characterization, differentiation, or diagnosis. It has been shown to improve visualization of pre-cancerous lesions, especially small flat lesions. Currently, a spray catheter is used to spray stains onto the mucosal lining of the intestinal tract during... Read More

Device for Fixation of an Adjustable Length Tube Through a Preformed Tract into a Hollow Cavity

6633 – Patients who can’t get enough food or liquids through the oral route use an enteral feeding tube. This may be due to decreased appetite, difficulty in swallowing and post-surgery that interferes with eating. The tube transfers food directly into the stomach through the abdominal skin via a surgically-created tract. Feeding tube is preferred for patients who require long-term nutrition... Read More

Droplet-based microrheometer for real-time monitoring of blood viscosity

6695 – According to the U.S. Centers for Disease Control, blood coagulation disorders could affect as many as 900,000 Americans. Up to 100,000 Americans die each year of deep vein thrombosis or pulmonary embolism (DVT/PE). Of those who survive, half will have long-term complications, including recurrence of DVT. In the United States, up to 5 million patients who have atrial fibrillation are also at... Read More

Stable, Highly active Ni(0) Catalysts for Cross-Coupling Reactions

6797 – Nickel catalysts can be both economical and powerful catalysts for applications in pharmaceutical, agrochemical, and polymer industries. Despite the potential for Ni catalysts in widespread processes like carbon-carbon coupling reactions, their application has been slowed due to challenges with stability and the hassles of catalysis under inert conditions. Due to the high demand and volatile... Read More

Zinc oxide nanoparticles for antimicrobial medical device coating and potential enzyme inhibition

6741 – Nearly half of the two million hospital acquired infections are associated with the insertion of a medical device. These infections are caused by attachment and growth of bacteria on the medical device, leading to possible biofilm formation that can lead to a localized or even systemic infection. Medical device associated infections are the leading cause of hospital acquired blood infections.... Read More

Dual c-Src/p38 Kinase Inhibitors

6826 – Triple-negative breast cancer (TNBC) represents one of the most difficult cancers to treat and there is currently no targeted therapeutics which are FDA approved. TNBC is found in 15-30% of all breast cancers. Kinases are a family of proteins that have been demonstrated to be important targets in cancer and are currently the focus of up to 25% of all drugs in development. p38... Read More

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