Office of Technology Transfer – University of Michigan
1-50 of 527 technologies within Life Science RSS ATOM

General Method for Increasing Bioavailability of Poorly Soluble Therapeutic Compounds Using Porous Hosts

2019-069 – Oral delivery is the preferred drug delivery route because of its convenience, high patient compliance, and cost-effectiveness. To be effectively delivered orally, the active pharmaceutical ingredient (API) must demonstrate high solubility in gastric and other physiological media to achieve effective absorption. As a consequence, otherwise promising drug candidates that suffer from poor... Read More

Orientation-Independent Compositional MRI for Ordered Tissue

2019-280 – A hallmark of joint osteoarthritis (OA) is a progressive loss of cartilage that can cause painful joints or even mobility impairments if the loss becomes severe. MRI has the potential to detect early OA and thus will help scientists to develop an interventional strategy to protect or regenerate cartilage. However, conventional compositional MRI suffers from a well-known “magic angle effect... Read More

Therapeutic Vibration Device for Critical Care

7258 – Muscle, nerve, and bone atrophy pose a significant risk for patients receiving critical care, such as mechanical ventilation, even for hospitalizations as short as one week. Although aggressive physical therapy and early mobilization of patients is effective in reducing the length of hospitalization, these measures require skilled physical therapists and may be difficult to apply to... Read More

Combination CD123 and C-type Lectin Molecule 1 Targeted T cells for Acute Myeloid Leukemia

7195 – Summary: This method engineers T cells that specifically target leukemia cells for destruction, which is a targeted, less-toxic therapy for leukemia, including acute myeloid leukemia. Applications: · New method for engineering T cells  · AML treatment for high-risk patients Advantages:  · Provides an additional treatment option for AML patients  · Less toxic than current therapies  ... Read More

Fluorinated Cholesterol Compounds for use as PET Imaging Agents

2019-390 – Researchers at the University of Michigan have developed a suite of compounds and chemical syntheses for the production of 18F-radiolabeled cholesterols, which may be used for positron emission tomography (PET).  The compounds are analogs of NP-59, an iodine-containing norcholesterol that has been used for SPECT imaging to detect functional endocrine abnormalities associated with adrenal... Read More

Fluorinated Cholesterol Compounds for use as PET Imaging Agents

2019-036 – Researchers at the University of Michigan have developed a suite of compounds and chemical syntheses for the production of 18F-radiolabeled cholesterols, which may be used for positron emission tomography (PET).  The compounds are analogs of NP-59, an iodine-containing norcholesterol that has been used for SPECT imaging to detect functional endocrine abnormalities associated with adrenal... Read More

Fluorinated Cholesterol Compounds for use as PET Imaging Agents

7744 – Researchers at the University of Michigan have developed a suite of compounds and chemical syntheses for the production of 18F-radiolabeled cholesterols, which may be used for positron emission tomography (PET).  The compounds are analogs of NP-59, an iodine-containing norcholesterol that has been used for SPECT imaging to detect functional endocrine abnormalities associated with adrenal... Read More

Cerebral Blood Flow Monitor for Continuous, Real-time Monitoring of Traumatic Brain Injury (TBI)

2018-471 – Traumatic and other brain injuries are often followed by secondary ischemic damage to the brain that results from decreased blood flow. As high intracranial pressure (ICP) is often the cause of the decreased blood flow, ventriculostomy catheters and intraparenchymal monitors have been employed to measure ICP. However, there are no reliable methods for directly monitoring cerebral blood... Read More

A Microfluidic System for Measurement of Red Blood Cell Deformability

2019-203 – The size and stiffness, or deformability, of biological cells can be important attributes when studying disease states. Red blood cells (RBC) in particular exhibit a unique ability to deform when healthy that allow them to be transported in microvasculature. Changes to this deformability have been implicated in sickle cell anemia, malaria, and diabetes. Microfluidic technologies have been... Read More

Droplet-based Microrheometer for Real-time Viscosity Monitoring of Blood Coagulation

6695 – Approximately 4.5 million patients are transfused with nearly 21 million blood components each year in the U.S. alone. Studies indicate that reductions in red blood cell (RBC) deformability or the use of older blood is associated with increased risk of post-operative complications and negative outcomes. Over 12 million patients visit the emergency room every year because of chest pain,... Read More

Tissue Resuscitation Using Low Frequency Acoustic Stimulation to Treat Ischemia

6857 – Pathological conditions with decreased or low blood flow (ischemia) kill or incapacitate millions of people annually. Examples of such conditions include hemorrhagic shock, cardiogenic shock, congestive heart failure, cardiac arrest, septic shock, intestinal ischemia, myocardial ischemia, stroke, traumatic brain injury, sickle cell vaso-occlusive crisis, burns, compartment syndrome, and... Read More

Nanocomposite Hydrogel for 3D Bioprinting

7700 – 3D bioprinting is a tissue engineering technique that can produce biocompatible, complex three-dimensional structures from digital models, analogous to conventional 3D printing for plastic based materials. This is accomplished using materials collectively known as bioinks, which include broad classes of compounds like hydrogels or decellularized extracellular matrix proteins to create... Read More

Incentive Spirometer

Internet of Things - Incentive Spirometer

2019-065 – The incentive spirometer (IS) is a common device used in hospitals to improve the respiratory function of patients with lung illnesses and all patients following operations. The device is designed to incentivize patients to take deep slow breaths several times an hour. To quick or too low a breath is inadequate. Utilization of the device is often suboptimal requiring constant... Read More

DC Handle - 1

DC Handle - Cardiology Stethoscope Handle

2018-277 – The "Cardiology Stethoscope Handle" allows individuals with limited dexterity to hold and use a cardiology stethoscope effectively.  In order to use a cardiology stethoscope, individuals must be able to listen through both the bell and diaphragm.  A standard fixed handle cannot be used on a cardiology stethoscope as it would block the use of either the bell or diaphragm.  The "Cardiology... Read More

The DICE Approach

7564 – Additional Information coming soon!

Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase

2018-281 – Cancer is the 2 leading cause of death in the United States.  In 2018, an estimated 1.7 million new cases of cancer will be diagnosed in the United States and over 600,000 people will die from the disease. Although many therapeutics exist to treat cancer of varying types, these therapies often fall short of adequately treating the disease and can have detrimental side effects. Our... Read More

SiMREPS Analysis Software - v 1.0

6250-1 – This package contains installers for two programs that perform single-molecule kinetic fingerprinting (SiMREPS=single-molecule recognition through equilibrium Poisson sampling) analysis using one or more grayscale TIF stacks (movies) as input. The first program generates intensity-versus-time traces form grayscale TIF stacks for subsequent kinetic analysis. The second program performs... Read More

Cooper Urinary Tract Infection Program (CUTIP): Multifaceted Urinary Tract Infection Quality Improvement Program

2018-318 – The Cooper Urinary Tract Infection (UTI) Program (CUTIP) is a multifaceted evidence-based infection control program for UTIs in Long Term Care Facilities (LTCF) that uses an algorithmic process, staff education, and change champions to improve patient outcomes. Through use of best practices, CUTIP improves assessment and diagnosis of UTI in LTC residents. This meets the healthcare requisites... Read More

The cryopreservation of human tissue samples for subsequent culture of live tissue

7532 – Over the past several decades, there has been an increasing need for better cryopreservation of tissue samples as well as increased research to tackle this problem. To-date there is a large amount of media used for the cryopreservation of cells from culture. However, there are still issue with freezing and thawing live tissue samples. This is largely due to crystallization that occurs on the... Read More

Clot-Buster Aspiration Catheter for Complex Vascular Navigation and High Volume Clot Removal

7305 – Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. The formation of a thrombus can occur within the heart or any artery or vein in the body, leading to a myriad of medical problems such us myocardial infarction, stroke, pulmonary embolism and deep venous thrombosis among many others. Although pharmacological... Read More

Peptide Specific for Fibroblast Growth Factor Receptor 2 (FGFR2) for the Detection and Treatment of Epithelial-Derived Cancers

7309 – Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane receptor tyrosine kinase that signals cell division, growth and differentiation. Defects in FGFR2 expression and signaling are oncogenic and occur in some of the most aggressive and common cancer types, including breast, prostate, esophageal and colorectal cancer. FGFR2 is therefore a promising early cancer biomarker and an... Read More

Identification and Use of Intestinal Resident Bacteria that Mediate Protection Against Enteric Pathogens

7130 – The high susceptibility of neonates to intestinal infections has been assumed to be largely due to immaturity of the immune system, but the mechanism remains unclear. Resident intestinal bacteria provide several benefits to the host. A major function of the gut microbiota is to protect the host against colonization by pathogens; however, the specific group of bacteria that mediates... Read More

A High-throughput Fluorescence Assay for the Determination of Spontaneous Viral Mutation Rates

7383 – The technology disclosed is a Luria-Delbruck fluctuation test for influenza virus mutation rates that scores reversion to fluorescence in a set of 12 mutant green fluorescent proteins (GFP). Globally, seasonal influenza is a major cause of severe respiratory infections, leading to excessive hospitalizations and 1 million deaths/year. The global influenza market (vaccines, antivirals, and... Read More

Generation of a Floxed TERT mouse for conditional analysis of telomerase function

7354 – Telomeres are important for protecting the ends of chromosomal DNA as we age. They progressively shorten over time, but this process may undergo abnormal alteration during disease such as cancer. Telomerase is the enzyme complex responsible for extension of telomeres. More specifically, telomerase reverse transcriptase (TERT) is the catalytic portion of this complex responsible for telomere... Read More

FIZZ1 Knockout Mouse

7353 – FIZZ1 (found in inflammatory zone) is a cysteine rich secreted protein. It is encoded by a gene known as Retnla or Remα. Upon deletion or overexpression of the gene, researchers have found that it has many roles in the regulation of fibrosis, pulmonary allergic inflammation, immune response, tissue remodeling, wound healing, and infection. However, most of the studies to date have been... Read More

Ear splint to correct congenital ear deformities

7199 – Congenital ear deformities such as low grade microtia, lop ear, Stahl ear, cryptotia, or prominotia are fairly common in infants. Currently, there are two ways to treat ear deformities: ear molding and ear surgery. Surgery is costly, and the risks of anesthesia and other complications usually defer surgery until the child reaches six years of age. However, deformities of the ears can lead to... Read More

Hydro-Seq: High Sample Efficiency Single Cell Whole Transcriptome Analysis Technology

7243 – To adequately diagnose and treat cancer, cancer cells are studied for particular gene expressions. Research has shown that the most important cells to look for are circulating tumor cells (CTCs) as these give rise to cancer. Traditional technologies for studying gene expression look at a population average, which masks diversity that is often seen in cancer patients. It is estimated that CTCs... Read More

Development of Amnion-Like Tissue From Human Pluripotent Stem Cells

7115 – The amniotic membrane (AM) forms the inner layer of placenta surrounding a fetus during pregnancy, allowing successful embryonic implantation, providing protection against physical trauma, maintenance of constant temperature, and amniotic fluid flow that assists in musculoskeletal development. Failure of the embryo to implant contributes to loss of pregnancy, which occurs at a rate of 10-12%... Read More

ALT TEXT: Artificial muscle construct for treating neuromas

Artificial muscle peripheral nerve repair tool kit for treating neuromas

5871 – This technology uses electrical stimulation and a tissue engineered artificial muscle derived from the patient to treatment neuromas (painful nerve growths). This reduces the pain experienced by the patient. Neuromas are often result from the nerves left behind after a limb amputation. About 1.7 million limb amputees are present in the US. About 75% of limb amputees have report severe limb... Read More

Inhibitors of Gram-negative bacterial growth, specifically uropathogenic E. coli

7133 – Center for Disease Control (CDC) has declared that one of the biggest public health concerns that we currently face is a gram-negative bacterium. These bacterium cause many diseases and are inherently hard to treat. In addition, these bacterium also adapt quickly and become resistant to most of the available antibacterial/ antibiotic drugs. In urinary tract infections (UTIs), E. coli is often... Read More

Two-Phase Technique to Remove Calcified Plaques and Restore Blood Flow Coupled to A Catheter Temperature Control System in Atherectomy

7229 – The technology disclosed is a novel two-phase atherectomy technique to restore blood flow with minimized cutting force and temperature rise. The method can be used as a safer alternative to existing atherectomy techniques. Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Cardiovascular disease is predominantly cased by atherosclerosis—a condition where... Read More

Tourniquet Optimized for both Civilian and Military Trauma Use

7205 – Tourniquets help save lives by constricting blood flow to a traumatized limb thereby preventing excess blood loss in a medical emergency. Existing tourniquets are primarily designed for use by medical professionals and combat personnel and such as the military and law enforcement agencies. Application of these types of tourniquets can be painful and physically challenging, in part, due to a... Read More

Moisture imaging of wound and burn depth for clinical assessment

6458 – Physicians and surgeons treating wounds and burns perform debridements simply according to how the insult looks. There is no objective or well-accepted method to assess wound depth or other characteristics. Punch biopsies may be used to evaluate wounds, but the procedure may impair restorative processes and cause infection. A single biopsy also does not allow for wound observation at multiple... Read More

A Molecular Adjuvant for Cancer Immunotherapy

6869 – At their most basic, vaccines are comprised of antigens to mount an immune response against, for instance the surface proteins of influenza, and another component (called an adjuvant) to help stimulate the desired immune response against the antigens. Vaccines have been critical to the prevention of infectious disease over the last 100 years, helping to provide protection against diseases... Read More

Prevention and Treatment of Traumatic Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva

6934 – Heterotopic ossification (HO) is a severely debilitating formation of abnormal bone growth resulting from trauma-induced injury to musculoskeletal and central nervous systems, including major burns and orthopedic interventions. Estimated to complicate up to 80% of hip replacements and 20% of spinal cord injuries in the civilian population, HO also affects more than 60% of military personnel... Read More

Scalable Multiplexed Drug-Combination Screening Platform Using 3d Microtumor Model for Precision Medicine

7222 – Drug Combinations have been an advantageous for the treatment of cancer as targeting two pathways can lead to an improvement in efficacy and has been shown to aid in overcoming resistance mechanisms. Clinical trials involving combinational therapies are very costly and time consuming, thus most pharmaceutical companies first assess drug combinations in-vitro. Current screening methods make... Read More

Contact-free nanoscale temperature sensor

7156 – The real-time, high throughput, repeatable, nanoscale mapping of temperature is needed in many areas of industry and public health. However, currently available technologies lack certain features; for example, contact-based methods is a destructive method, and relies on scanning which is inherently slow. Alternatively, optical microscopy-based methods, such as fluorescence microscopy,... Read More

Methods of characterization of cancerous lesions

6907 – Early cancer screening with modern technology has markedly improved the detection of small neoplasms, or abnormal growths, that were previously impossible to identify. However the likelihood that these early detected neoplasms will progress to invasive metastatic cancer is unknown. These abnormalities are often treated as though they will potentially become invasive cancer which forces... Read More

Mood-Enhancing Dynamic Commercial Lighting

6654 – Sleep and mood disorders such as insomnia, jet lag, and seasonal affective disorder (SAD) affect many adults, and are related our sleep/wake cycle, also known as our circadian rhythm. According to a 2011 poll performed by the National Sleep Foundation, as many as 43% of Americans between the ages of 13 and 64 say that they rarely or never get a good night’s sleep on weeknights. In the United... Read More

Clinical Augmented Reality Evaluation of Patient Brain Activation in Real-Time

7010 – Clinical exam doctors investigate a patient’s body for signs of disease or trauma, however when trying to get information about pain or emotional experiences (such as anxiety), the doctor must rely on the patient’s ability to communicate which becomes a problem if the patient cannot communicate verbally or with writing (such as being unconscious or having a mental disability). Measuring... Read More

Mobile app for knee replacement perioperative care

7020 – The number of knee replacement surgeries has almost doubled since 2001, with over 700,000 cases performed in 2011, and are now one of the most costly procedures in the US, with an aggregate cost of over $9 billion in 2008. As The Centers for Medicare and Medicaid Services implement payment models that penalize hospitals for poor outcomes, it has become increasingly important to monitor,... Read More

IMassFrag: Metabolite Identification Software

7009 – IMetabolite identification (MetID) of drug candidates is a critical step in drug discovery and development. MetID can aid medicinal chemists in modifying the metabolic soft spots of a drug candidate in the early stage of drug discovery. Metabolic modification of the compounds may change the pharmacological activity and toxicity of a drug molecule. To reduce the risk of costly... Read More

Respiratory rhythm matrix (RRM), a new method for sleep apnea detection

6918 – Sleep apnea can be defined as a group of disorders characterized by abnormalities of breathing while sleeping. Breathing is interrupted from a few seconds to minutes, occurring several times over the course of a routine sleep. Airway blockage occurs as the patient sleeps. The blockage occurs between the soft palate and/or the back of the tongue and the pharynx. As the patient breathes, the... Read More

Chromosome Breakability Index

6835 – This technology allows researchers to determine how likely a given portion of the genome is to translocate. Genomic translocations occur when one section of the genome is moved to another section of the genome, sometimes disrupting or removing important genetic information. These translocations can lead to diseases, including cancer. Being able to predict where translocations will occur... Read More

Computer Tool for Collaborative Play for Child with Autism Spectrum Disorder

6830 – This technology provides a computer-based medium for patients with Autism Spectrum Disorder (ASD) to interact and learn important tactile skills, all in a fun environment developed with feedback from patients and physicians. With [increasing rates of ASD] (http://www.cdc.gov/ncbddd/autism/data.html), innovative new treatments are needed to address the issue. ASD patients tend to respond... Read More

Computer game tool for physical therapy

6828 – This technology helps patient’s complete physical therapy in fun and engaging ways in the comfort of their own home. A major problem in physical therapy is patient compliance with repetitive tasks. But it’s been shown that videogames can be used to increase compliance and enhance recovery. This technology harnesses these advantages of videogames to create a fun tool to help recovery of... Read More

Corticocardiac Coupling as a Risk Factor for Sudden Death

6687 – Sudden death occurs in more than 400,000 Americans annually and is a significant and under-recognized consequence of stroke. Identification of patients at risk for sudden death after stroke poses a major challenge. Recently, an animal model of stroke uncovered a surge in synchronous brain and heart electrical activity (corticocardiac coupling) hours before sudden death. This finding was... Read More

Fiberless Optoelectrodes for Multicolor Neural Stimulation

6575 – Optogenetics is a relatively new technology in the field of neuroscience that combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within a neural circuit. Neurons now may be controlled with optogenetics for fast, specific excitation or inhibition within systems as complex as freely moving mammals. Optogenetics is based on... Read More

Monolithically-Integrated Micro-LEDs on Silicon Substrate for Implantable Neural Probes

6277 – Implantable neural probes with monolithically-integrated micro-LEDs on silicon substrates have been demonstrated at the University of Michigan. Monitoring how neural circuits work together and perform computational processing is critical to the understanding of brain function and behavior. Through optogenetics, photosensitive ion channel proteins called opsins can be introduced into specific... Read More

F3: Female Foley Facilitator

6643 – Foley catheters are soft, plastic or rubber tubes that are placed transurethrally into the bladder to provide continuous drainage and relief when there is urinary retention, to monitor urine output for critically ill patients, to manage urination during surgery, and to provide end-of-life care. However, these indwelling catheter’s can increase the patient’s risk of death due to urinary... Read More

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