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Scalable Multiplexed Drug-Combination Screening Platform Using 3d Microtumor Model for Precision Medicine
7222 – Drug Combinations have been an advantageous for the treatment of cancer as targeting two pathways can lead to an improvement in efficacy and has been shown to aid in overcoming resistance mechanisms. Clinical trials involving combinational therapies are very costly and time consuming, thus most pharmaceutical companies first assess drug combinations in-vitro. Current screening methods make... Read More
Mold for Making Highly Symmetric Three Dimensional Microstructures
7175 – This technology offers improvements to the creation of axisymmetric microstructures that are well-suited for use as a resonator in vibratory gyroscopes. Gyroscopes measure angular motion and they are a vital component in internal measurement units, which monitor and guide the motion of aircrafts and unmanned vehicles. Miniaturization of devices and the use of microelectromechanical systems,... Read More
Contact-free nanoscale temperature sensor
7156 – The real-time, high throughput, repeatable, nanoscale mapping of temperature is needed in many areas of industry and public health. However, currently available technologies lack certain features; for example, contact-based methods is a destructive method, and relies on scanning which is inherently slow. Alternatively, optical microscopy-based methods, such as fluorescence microscopy,... Read More
Frequency Comb Based Multidimensional Coherent Spectroscopy
7155 – There is a large need for spectroscopic technology to be used for chemical identification. An optical spectrum can act as a fingerprint for different molecules, allowing identification, opening up the door for various applications. One area that spectroscopy has become a vital tool is the intelligence community for stand-off chemical detection (for example, detecting improvised explosive... Read More
Method and Instrumentation for using a Drilling Pipe/Mud as a Single Conductor Transmission Line
7147 – Exploratory drilling, such as in the oil, gas, and mining industries, has come to rely on the collection and transmission of many streams of real-time data to monitor and guide drilling. This has allowed safer, smarter, and more environmentally conscious drilling. As significant oil reserves become harder to find and reach, such data collection and transmission technologies become even... Read More
High spatial frequency femtosecond laser induced periodic surface structures for single crystal patterned semiconductors
6809 – Surface corrugation is one of the most fundamental phenomena in materials science. The interaction between multiple intense ultrashort laser pulses and solids universally produces a regular surface corrugation. Laser induced periodic surface structures (LIPSS) are a form of corrugation produced by the use of light and they appear universally in metals, semiconductors, insulators. While a... Read More
Silicon Micromachined High Flow Gas Pump
6502 – The creation of new MEMs devices including sensors and lab-on-a-chips are becoming more reliant on microscale systems which provide better efficiency, cost effectiveness, portability and in some cases accuracy. One important component of many microscale devices are efficient micropumps which can pump fluids or gases through a system or create vacuum environments. Micropumps are important in... Read More
A Non-Contact On-Wafer S-Parameter Measurements of Devices at Millimeter-Wave to Terahertz Frequencies
6475 – The millimeterwave (MMW) and terahertz (THz) frequency spectrum of electromagnetic waves have attracted significant interest in science and engineering. The advances in active and passive Monolithic Microwave Integrated Circuit (MMIC) technology have opened up opportunities for new applications such as ultra-fast wireless point-to-point communication, miniaturized high-resolution imaging... Read More
Equipment condition monitoring and decision-making using nonlinear regression
6591 – Whenever manufacturing machinery unexpectedly goes offline, considerable money and productivity is lost. Equipment condition monitoring is a way to avoid that by constantly monitoring machine conditions for variations indicating faults that require preventative maintenance. At its base, it involves reading vibration, ultrasound, thermography, and other monitoring data and comparing them... Read More
Reconfigurable Mesh Filters for Broadband Terahertz/Infrared Wave Modulation
5731 – A research team at the University of Michigan has developed a terahertz (THz) modulator that exhibits broadband, high amplitude modulation index. The use of THz technologies in many industries including semiconductor metrology, food quality processing, homeland security, medical imaging and communications, has led to staggering growth in the field in the last decade. Efficient light sources... Read More
Terahertz DNA Bio-Sensor Architecture Comprising Doubly-Corrugated Spoofed Surface Plasmon Polariton Waveguide
5568 – A label-free, Mach-Zehnder interferometer (MZI) based biosensor has been developed by a research team at the University of Michigan. The biosensor has potential to detect molecular binding without the use of conventional fluorescent tags, easing preparation requirements and facilitating efficient analysis. Biosensing has become increasingly important to many industries including biodefense,... Read More
High Temperature Cathode Heater
5595 – The following NPD does not include the main aspects of the invention, namely boron nitride and rhenium. It is thought the use of these words would disclose important information. However, omitting them has resulted in mildly unattractive wording in some cases, specifically in the heading. A University of Michigan research team has developed a stable high-temperature cathode heater for... Read More
Multi-Resonant Circuit for Quadrapole Mass Spectrometry
4867 – We have created a novel circuit to drive mass spectrometry and ion trap systems with multiple frequencies in a concurrent matter. This enables substantially enhanced performance of said systems, while using the same sensors. The methodology developed here enables two-pole or symmetric three pole multi-resonant tank circuits. We achieve this, using a network of capacitors and inductors which... Read More
Thin Disk Extraction During Pumping Laser Amplifier
6154 – A thin disk extraction during pumping (EDP) laser amplifier for use in ultra-high peak-power laser systems has been developed at the University of Michigan. The resulting ultra-high peak-power laser systems that utilize the technology demonstrate increased repetition rates and average power values. High repetition rates and average power values are often required for many laser... Read More
A Compact Lens Array System
5745 – Researchers at the University of Michigan, as part of the Electrical Engineering and Computer Science Department have developed a low-cost, high-resolution and portable microscope system for biological imaging and analysis. Optical microscopy is the standard used for biological system visualization as well as identification, diagnosis and monitoring of many diseases including sickle-cell... Read More
High-Resolution Fluid Pipetting Device
5232 – Handheld pipettes for liquid handling are ubiquitous in wet laboratories worldwide. Over 1.5 million pipettes and 10 billion pipette tips were sold worldwide in 2006, and sales numbers are expected to increase. In addition, the market for high-throughput liquid handling devices is expected to grow as corporations, hospitals, and academic labs aim to increase throughput in drug discovery... Read More
Virtually Noncontact Excitation System
5211 – An excitation system includes a pair of piezoelectric elements configured to apply respective excitation forces to a test structure, a clamp including an adjustable arm, the adjustable arm being configured to capture the test structure between the pair of piezoelectric elements, a controller coupled to the pair of piezoelectric elements and configured to generate a respective excitation... Read More