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Molecular Cloning and Functional Expression of Rat Type I Voltage-gated Sodium Channels
1567 – UM File # 1567 Background Technology Description Applications Advantages
1610 beta Cell Line
1786 – UM File # 1786 Background Technology Description Applications Advantages
Molecular Cloning and Functional Expression of Rat Type I Voltage-gated Sodium Channels
1844 – UM File # 1844 Background Technology Description Applications Advantages
Sodium Channel beta2 Subunit Knockout Mice
1804 – UM File # 1804 Background Technology Description Applications Advantages
Subvolume Identification from DCE MRI for Prediction of Treament Response
5352 – The impact of therapy on cancer as well as normal organs is hard to predict by conventional means, including tumor size, mean value of physiological image parameters in the tumor, or even voxel-by-voxel analysis of physiological images taken before and during treatment. Additional information for tumor response to therapy might be obtained through physiological parameters, which however... Read More
Subvolume Identification for Prediction of Treatment Outcome
5351 – The impact of therapy on cancer as well as normal organs is hard to predict by conventional means, including tumor size, mean value of physiological image parameters in the tumor, or even voxel-by-voxel analysis of physiological images taken before and during treatment. A change in tumor size often occurs too late for prediction of response. A mean value of a physiological image parameter... Read More
Modulating toll-like receptor activity
4366 – UM File # 4366 Background The Toll family of polypeptides is remarkably conserved across the taxonomic kingdoms, suggesting essential role in physiology. These peptides share homologous domains and signaling pathways, which are used to trigger inflammatory and immunological responses. However, the function of these proteins extends beyond host defense. As expressed on leukocytes,... Read More
Small Molecule Inhibitors of Mcl-1 and the Uses thereof
5163 – According to the latest report, the world market for cancer therapies is estimated to be $54.4 billion. The vast majority of current anti-cancer therapies act by activating cell death pathways, Apoptosis is the process of PCD (programmed cell death) that is maintained by a balance between pro-apoptotic and anti-apoptotic stimuli. Resistance to apoptosis is one of the hallmarks of human... Read More
Treatment of Rheumatoid Arthritis and Other Erosive Bone Conditions with Peptidomimetics
5313 – Rheumatoid arthritis (RA) afflicts approximately 2.5 million people in the US, with over 50,000,000 suffering from the disease globally. There is no cure for RA. Currently available treatments can alleviate some symptoms and modestly slow disease progression; however these therapies fail to provide relief and adequately slow joint damage in all patients. New therapies are needed which... Read More
Profiling Inflammatory Responses with Microfluidic Immunoblotting
5676 – This is a microfluidic immunoblotting device for rapid, parallel profiling of protein components in any biological sample. It enables simultaneous detection of multiple proteins in a single lane of a conventional Western blot membrane with significantly reduced antibody requirements. Since its development over 30 years ago, the Western blot has been an integral analytical technique for the... Read More
Cell-Specific Mineralocorticoid Receptor Theranostics for Inflammatory Diseases
5525 – Current mineralocorticoid receptor (MR) antagonists have side effect when treating cardiovascular diseases. Activation of MRs promotes inflammation and cardiovascular disease. Patients suffer from these diseases can benefit from MR blockage by MR antagonists, such as spironolactone and eplerenone. However, these traditional MR antagonists have limitations including off-target effects and... Read More
A Compact Lens Array System
5745 – Researchers at the University of Michigan, as part of the Electrical Engineering and Computer Science Department have developed a low-cost, high-resolution and portable microscope system for biological imaging and analysis. Optical microscopy is the standard used for biological system visualization as well as identification, diagnosis and monitoring of many diseases including sickle-cell... Read More
An Integrated Electrohydrodynamic Jet Printhead for Flexible Micro/Nano-Manufacturing
5572 – Researchers from the University of Michigan Mechanical Engineering Department have developed a technology that allows electrohydrodynamic ink jet printers to print on a wider range of surfaces with better droplet control. The technology enables the printing on both conductive and non-conductive surfaces, as well as those with irregularities and non-planar sections, which is important for... Read More
Use of Coaggregating Lysobacter Gummosus as a Antibacterial Biocontrol Agent
5467 – This technology utilizes the bacteria Lysobacter gummosus, and its potent antimicrobial activity, to destroy target bacteria within biofilms. Recent studies revealed that Lysobacter gummosus coaggregates, or becomes attached, with many diverse bacterial species within multi-species biofilms. Furthermore, Lysobacter gummosus exhibits potent antimicrobial activity, presumably via secreted lytic... Read More
Methods for the detection and diagnosis of osteoporosis and osteogenesis imperfecta using atomic force microscopy
5466 – This technology utilizes atomic force microscopy (AFM) imaging and two-dimensional fast Fourier transform (2D FFT) analysis to examine collagen fibril D-spacing in collagenous tissues. Collagen is the major building block of many human tissues, including skin, tendons, and bone. Structurally, collagen molecules are arranged into fibrils that contain repeating staggered gaps termed D-periodic... Read More
Personalized non-invasive device to treat tinnitus
5507 – Tinnitus, commonly known as ringing in the ears, affects approximately 50 million people in the U.S. alone, with a particularly high prevalence noted in the aging population. Moreover, tinnitus is the most common disability among U.S. military veterans, for whom estimated associated costs exceed $2 billion annually. In a substantial number of tinnitus cases, symptoms can be severe to... Read More
EZ-ASSIGN Fortran Source Code for NMR Resonance Assignments
5729 – EZ-ASSIGN autamates and facilitates the process of protein NMR resonance assignments. It is fast, robust, and applicable to the most complex spectra. NMR assignment is the process where N pieces on data (spinsystems) need to be placed on M categories (sequence positions). For perfect data N=M. M is typically between 50 and 500. For M=100, there 100999897..2 =100! = 10^256 permutations. This... Read More
EGFL6 Blocking Antibody as a Cancer Therapeutic
5694 – Monoclonal antibody targeting ovarian cancer stem-cell growth and differentiation This monoclonal antibody (mAb) technology blocks ovarian cancer stem-cell (CSC) proliferation and migration, and consequently reduces ovarian tumor growth and metastasis. It therefore represents a promising potential new drug to treat ovarian cancer. A key growth factor was identified to be responsible for... Read More
Adjuvant Stem Cells Therapy for the Treatment of Colon Cancer
5656 – 1 million men and women are affected by colon cancer each year and researchers are continually developing adjuvant therapies to improve cancer treatment. In addition to surgery to remove tumors, chemotherapy and/or radiation are often used to kill off cancer cells that may have been left behind. When surgery is not an option, targeted therapies can be used to specifically alter proteins that... Read More
Apyrase Treatments for Eradicating Infections and Heterotopic Ossification
5550 – Treatment of burn wound infection with apyrase and antibiotics in a mouse model resulted in improved bacterial killing by 1000 fold. Concomitantly, elevation of inflammatory cytokines and bacterial colonization was decreased in the wound. Nosocomial or hospital acquired infections (HAI) are a significant healthcare burden and concern. HAIs result in approximately 90,000 deaths per year in the... Read More
Microfabricated Passive Vapor Preconcentrator/Injector Designed for Microscale Gas Chromatography
5162 – Microscale gas chromatography is a separations technique that offers the potential for analyzing volatile organic compounds. Pre-concentration is necessary to concentrate vapors to detectable levels prior to injection into the separation columns. Most devices use a pump to draw air through an absorbent material within the walls of the device, which results in a significant power... Read More
Activating Dark Silicon Through Computational Sprinting
5078 – Computer and personal electronic processors are currently designed to work continuously at a safe operating power to protect components from overheating. Although this design paradigm suits the continuous processing demands of batch computation systems, it is not ideal for responsive systems. Digital cameras, mobile phones, barcode readers and tablets require short intervals of processing... Read More
Stretchy materials as electrical conductors
5557 – Neurosynthetic implants and stretchable electronics require highly conductive materials that are elastic. Macroscale stretching of solid materials cause elongation and bending of chemical bonds that are needed for the transport of electrons along orbitals, causing a reduction in electrical conductivity. Liquid metals have high electrical conductivities and can flow, but cannot be stretched... Read More
Synthesis of Conjugated Polymers with Directed Alignment
5439 – Researchers at the University of Michigan have developed a method for the directed alignment of conjugated polymers (CPs). CPs are fast emerging as active materials for various optoelectronic applications such as organic solar cells and thin film transistors since they demonstrate highly anisotropic optical and electronic properties such as absorption, emission, and conductivity. The... Read More
Implantable Electrostimulation and Recording Devices from Gold Nanoparticle Composites
5419 – Neural prosthetic devices, commonly found in the form of artificial pacemakers, spinal cord implants, and cochlear implants, are showing much promise in treating neurological conditions and traumas. A major problem with using these devices lies in the body’s rejection of foreign implants; accumulation of scar tissue from immune response lowers the effectiveness of implants. To drastically... Read More
Methods and Devices for Generating High-Amplitude and High-Frequency Focused Ultrasound With Light-Asorbing Materials
5233 – Obtaining high-frequency ultrasound waves while maintaining strong pressure amplitudes at focal spots is a major challenge in the field of ultrasounic transducers. Conventional ultrasound transducers such as those based on piezoelectric technologies are often used to generate high-amplitude waves. However, conventional transducers have low operation frequencies (<5 MHz), and large... Read More
Graphene Oxide-Based Circulating Tumor Cell Capture Device
5137 – The quantification of circulating tumor cells (CTC) present in the blood stream of metastatic cancer patients is a valuable tool for the early detection of the disease, its staging, as well as for the assessment of the patient’s response to their individual anti-cancer therapy. However, the process of quantitating CTCs is extremely challenging given the scarcity of these cells (1 for... Read More
Fluorescent Dye Conjugate
5608 – This is a dendrimer conjugated fluorescent dye that can be used as a bioorthogonal chemical reporter for probing cellular processes. Following a ‘click’ reaction between an azide group on this dye and an alkyne moiety that has been incorporated into a macromolecule or metabolite in a cell, this fluorophore undergoes a 21-fold increase in fluorescence intensity. Given this excellent... Read More
Universal, Quantitative Antibody Labeling Platform
5514 – Newly developed antibody-conjugated fluorophore-labeled dendrimers offer improved sensitivity and quantitative analysis for a wide range of research and clinical applications. Current antibody labeling strategies are prone to batch-to-batch variability and are dependent on stochastic chemical reactions. Utilizing modified PAMAM dendrimer nanoparticles for antibody labeling with fluorophores... Read More
Polyurethanes Doped with S-Nitrosothiols for Nitric Oxide Release
5584 – This is a medical device coating polymer that incorporates nitric oxide (NO) donors that release NO into surrounding media and prevent thrombosis and platelet adhesion to the device, as well as biofilm formation. In healthy vasculature, endothelial cells generate NO to prevent thrombosis and platelet activation, but introduction of a foreign object disrupts vascular homeostasis and leads to... Read More
Lung Lymphocyte Killing Assay in Chronic Obstructive Pulmonary Disease
5661 – Chronic obstructive pulmonary disease (COPD) already afflicts some 15 million Americans and is expected to grow by 30 percent across the globe over the next ten years. Certain studies have correlated natural killer (NK) and T cells with increased lung damage, but the link between these cell types and COPD remains hazy. Researchers at the University of Michigan have developed a technique to... Read More
Mixed Disulfide Conjugates of Thienopyridines as Antiplatelet Agents
5574 – Current thienopyridines have side effects due to single-nucleotide polymorphism (SNP) of individuals and need 2-3 days to reach therapeutic concentration: Thienopyridinyl compounds are widely used as antiplatelet agents to prevent heart attack and stroke. In this category, clopidogrel (Plavix), ticlopidine (Ticlid) and prasugrel (Effient) are three commonly used prodrugs. These agents have to... Read More
Biological Separations with Magnetic Beads and Pathogen Removal
5577 – This technology enables targeted separation, and hence removal, of bacteria from liquids by using specially developed magnetic beads to label selectively bacteria or pathogens. Consequently, this technology can be used to clean blood products or pharmaceutical preparations from harmful bacteria. Affinity magnetic beads are commonly used to detect or concentrate biologics of interest. The... Read More
Cancer Stem Cell Vaccination and Treatment
5486 – This technology presents an effective and lasting treatment of patients with advanced cancer that have been treated with chemotherapy or radiation. It shows that cancer immunotherapy that specifically targets cancer stem cells (CSCs) provides significantly better anti-tumor immunity than immunotherapy that targets antigens present in bulk tumors. Cancer immunotherapy using dendritic cells... Read More
Inhibitors as Therapeutics to Target Cancer Stem Cells
5485 – About 22,280 new cases of ovarian cancer were diagnosed in the year 2012. The prevalence of ovarian cancer is 11.749 cases per every 10,000 individuals in the year 20092. Over 13,850 women will die of this disease3. Some patients do not response to platinum-based therapy and this problem causes low five year survival. ALDH/CD133 is considered as the marker for cancer stem cells.... Read More
Poly(lactic-co-glycolic) Acid Additives to Enhance Nitric Oxide Release from Diazeniumdiolate Doped Polymer Coatings
5436 – Nitric oxide (NO) is an endogenous vasodilator and a natural inhibitor of platelet adhesion, activation and aggregation. One of the key issues with the use of blood-contacting medical devices is their lack of hemo- and biocompatibility which leads to platelet adhesion and thrombosis. Polymers that release or generate NO locally at their surface exhibit greatly enhanced thromboresistivity... Read More
Diagnostic Polymerase Chain Reaction for Uropathogenic Escherichia Coli
5236 – Almost 50% of the global population will experience a urinary tract infection (UTI) at some point in their lives, and those who suffer from recurrent, UTI can have three or more episodes of infection per year. As the most common healthcare-associated infection, UTI accounts for more than 30% of infections reported by acute-care hospitals. Strains of bacteria known as uropathogenic E. coli... Read More
Fast Liquefaction of Wet Biomass
5406 – Microalgae are promising third-generation energy sources due to the large amount of biofuels stored in them. They can survive in undesirable aquatic and maritime environments, and do not compete with traditional food crops. When algae is harvested, they can either be dried and heated to generate lipids, or they can undergo a process known as hydrothermal liquefaction (HTL), which is more... Read More
Methods of Preparing Fluorine-18-Labeled Phenethylguanidines
5311 – According to the American Heart Association, an estimated 82.6 million American adults have one or more types of cardiovascular disease (CVD). As the leading cause of death in the U.S., accounting for 1 in 6 deaths, the early detection of CVD is crucial to the diagnosis and treatment of the disease. Nuclear medical systems, such as positron emission tomography (PET), have long been used... Read More
Improving the Education of Medical Professionals for Neurological Symptems
5504 – There are over 20,000 neurologists in the U.S. performing neurological assessments every day. Each of these neurologists attempt to identify the root cause of the symptoms observed in their patients. Many symptoms have complex origins and require extensive knowledge on the various nervous system pathways. There is a need for an educational tool that can provide the necessary pathway to... Read More
Return2Play - Your Tool for Concussion Recovery
5482 – Each year 1.7 million people sustain a traumatic brain injury in the U.S. These injuries contribute to a substantial number of deaths and cases of permanent disability. Specifically these injuries are more common in athletes engaged in physical sports. The treatment and monitoring of head trauma in athletes is a complicated and demanding process requiring continuous monitoring by a... Read More
Fluorescent Probes to Study Ion Channel Surface Expression and Trafficking
4665 – Ion channel function has been linked to disease states such as atrial fibrillation, supraventricular tachycardia, hypertrophic cardiomyopathy and hypertension, as well as headaches, the prevention of brain damage, and other disorders. Despite the clear links between ion channels and these diseases, there remains a need for an increased understanding of how these channels function and how... Read More
Selective Fluorination of Aromatic and Heteroaromatic Systems
5499 – This technology provides cheap and safe fluorination of aromatic and heteroaromatic systems for small and large scale syntheses. This method uses organometallic chemistry to form carbon-fluorine bonds under mild conditions, it is selective, general and suitable for a broad range of substrates. Addition of fluorine molecule(s) can enhance both drug pharmacokinetics by making it more... Read More
Compounds for Reducing Lysosome Storage in Lysosome Storage Diseases
5339 – Similar to the way food is digested in our stomach, cells break down harmful waste, viruses, bacteria, and other cellular components using organelles called lysosomes. Defects in this process results in storage of excess waste that is detrimental to the cell. Lysosomal storage diseases (LSDs) are a large group of over 50 rare inherited metabolic disorders due to improper lysosomal... Read More
Method for Creating Nitric Oxide Surfaces
4174 – Biocompatible Coatings for Cardiovascular Medical Devices This technology increases the biocompatibility for medical devices used in cardiovascular medicine such as artificial heart valves, vascular grafts, and catheters. This coating, which via catalysis generates antithrombotic nitric oxide from endogenous sources, reduces the activation of platelets and therefore reduces the risk of blood... Read More
Hybrid Multichannel Printed Circuit Board Microdrive
3822 – Over 10 million people in the U.S. suffer from an advanced form of a neurodegenerative disease such as Parkinson’s, Epilepsy, and Alzheimer’s. There has been theory, changing breakthroughs in the last 15 years regarding how these disease progress and manifest symptoms in patients. By working in the animal model, scientists have been able to experiment more freely and tackle more advanced... Read More
Ion Exchanged Pillared Clays for Selective Catalytic Reduction of Nitric Oxide
1615 – Pillared Interlayered Clay Catalysts for Selective Reduction of Nitrogen Oxide Pollutants. This technology is capable of selectively reducing nitrogen oxides (NOx), potent greenhouse gases, that are produced during combustion of fossil fuels. The catalyst, by employing, pillared interlayered clay structures, more efficiently reduces nitrogen oxides and is more compatible with... Read More
Metal Salt Catalysts for Enhancing Hydrogen Spillover
4324 – Hydrogen storage for next-generation fuel cells One of the most promising types of renewable energy lies in fuel cells that convert water to hydrogen fuel. As such, the safe and efficient storage of hydrogen has become a hot topic for the next generation of marketable fuel cells. The United States Department of Energy (DoE) has established a target for materials that are capable of storing... Read More
Closed Loop Log Domain Deep Brain Stimulation
5416 – Deep brain stimulation (DBS) of the sub-thalamic nucleus is an effective treatment for numerous neurological disorders such as tremor, dystonia, and Parkinson’s disease. However, despite much research, algorithms and systems for closed loop operation remain elusive. The spike sorting and principal component analysis (PCA) approach holds promise but requires significant computation, making... Read More
NOTCH2 Mutations are Common in Splenic Marginal Zone Lymphoma and Predict a Poor Prognosis
5388 – Lymphomas are a heterogeneous group of hematological malignancies that accounts for ~5% of all cancers worldwide. Due to their heterogeneity, lymphomas vary significantly in their severity, from indolent to very aggressive forms. Thus, accurate diagnosis and prediction of disease progression is very important in determining the best treatment course for each patient. Splenic marginal zone... Read More