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Surgical Knife
1907 – Anterior lens capsule surgery can often be a difficult procedure with existing surgical instruments due to the requirement to create small tears upon the fragile anterior lens capsule for cataract removal. A University of Michigan clinical ophthalmologist has designed and created a working prototype of a surgical blade for incising the intraocular tissue, such as the anterior... Read More
Inhibition of HIV Replication by Blocking IL-8 , GRO-alpha, and /or CXCR2 Function
1891 – Medical therapy for infection with the human immunodeficiency virus type 1 (HIV-1) has improved over the last several years. However, many patients still fail to respond to the available pharmacologic agents, due to drug resistance and other factors. In addition, the antivirals currently available are often not well tolerated by patients. The currently available drugs for treating HIV-1... Read More
CAD-MRI-and CT-Based Production of Tissues for Tissue Engineering
1853 – Over one million surgical procedures in the United States each year involve bone and cartilage replacement. Head and neck reconstructions present a complex challenge requiring a high degree of precision in implant fabrication. Immunological complications, donor infectious diseases, premature transplant resorption, and lack of donor material further strain these procedures. Consequently,... Read More
Pluripotent Mouse Embryonic Stem Cell Line: Pat 5
1862 – This is a research tool available for a materials license or material transfer agreement. Pat5 mouse embryonic stem cells were derived from 129X1/SvJ mouse embryos. Genetic mutations introduced into this cell line by homologous recombination with gene targeting vectors can be passed on through germ cells (sperm) to produce mice with targeted genetic mutations.
ADAMTS13 Exons 1-6 Deficient Mice
2683 – Mice bearing a homozygous targeted replcaement of ADAMTS13 exons 1-6 with a neomycin cDNA cassette
Transgenic Mouse Model for Basal Cell Carcinoma
1828 – Basal cell carcinoma (BCC) is the most prevalent form of skin cancer. Annually, approximately 75% of the 1,000,000 new cases of skin cancer diagnosed in the United States are basal cell carcinomas. A major hurdle in the development of new treatments has been the lack of an adequate BCC mouse model that will help scientists understand the genetics and pathobiology of this common disease,... Read More
Positron Emitting Internal Marker for Identification of Tissues by PET Scanning
1806 – Medical diagnostic imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often rely on targeting aids or landmarking devices, which help identify anatomical locations of visualized areas. One of the most common methods used to date is the radiopharmaceutically-assisted technique. This method depends on cellular uptake of suitable imaging... Read More
Compositions and Methods Useful in Prophylaxis and Treatment Conditions Related to Oxidative Damage, Endotoxemia and Chemical Toxicity
1855 – Endotoxic shock is a condition, provoked by the release of lipopolysaccharide (LPS) from the outer membrane of most gram negative bacteria (e.g., Escherichia coli; Salmonella tymphimurium). One example of a condition involving Endotoxic shock is sepsis. Sepsis is a systemic reaction characterized by arterial hypotension, metabolic acidosis, decreased systemic vascular resistance,... Read More
Sodium Channel beta1 Subunit Knockout Mice
1983 – Sodium Channel beta1 Subunit Knockout Mice
Mineralization and Cellular Patterning on Biomaterial Surfaces
1658 – Many biomedical procedures require the provision of healthy tissue to counteract the disease process or trauma being treated. This work is often hampered by the tremendous shortage of tissues available for transplantation and/or grafting. Tissue engineering may ultimately provide alternatives to whole organ or tissue transplantation. In recent years, the ability to regenerate tissues and... Read More
Technique for Making Angle-Independent Ultrasound Volume Flow Measurements
1710 – Volume flow measurements have always been the most desired ultrasound flow measurement. Unfortunately, such measreuments have been difficult to obtain or the accuray has been limited, and because of this, volume flow measurements are almost never used. The preferred embodiment is useful in an ultrasound system for measuring the volume of fluid flow within a region of interest. In... Read More
Identification of the Gene Causing Familial Mediterranean Fever
1618 – Familial Mediterranean Fever (FMF) is a recessively inherited disorder characterized by dramatic episodes of fever, serosal inflammation and abdominal pain. This inflammatory disorder is episodic, and patients often develop progressive systemic amyloidosis from the deposition of the acute phase reactant serum amyloid A. In some patients, progressive systemic amyloidosis can lead to kidney... Read More
Therapeutic effects of ELR-containing CXC chemokines in Acute Liver Injury
1597 – The liver is the only vital organ, aside from the brain, for which there is no pharmacological, mechanical, or extra corporeal means of support for a failing organ. Although a patient’s ability to restore his or her pre-operative hepatic mass following major liver resection is well-known, a significant problem with efforts to promote hepatic regeneration is that many agents have limited... Read More
CIPER: A Novel Protein That Promotes Apoptosis and NF-kB Activation
1550 – Most cells in the body die through a non-inflammatory, energy-dependent form of cell death called apoptosis. Recent research into the molecular mechanisms of apoptosis has revealed that apoptosis is a genetically programmed process that can become deranged when the components of the cellular apoptotic machinery are mutated or present in inappropriate quantities. Dysregulation of apoptosis... Read More
Method for Detecting Early Atherosclerosis and Vascular Damage Using Radioactive Tracer and Intravascular Radiation Detector Catheters/Devices
1555 – Atherosclerosis is a condition in which there is a chronic inflammatory response in the arterial walls, causing hardening of the arteries. While determining the true frequency of atherosclerosis is difficult as it may be asymptomatic, approximately 11 million Americans are estimated to have chronic coronary artery disease. While conventional imaging by contrast angiography or... Read More
High Resolution Models of G Protein Coupled Receptor Transmembrane Domains
1529 – Many currently available drugs and act by binding to one or another G protein-coupled receptor. Unfortunately, the powerful techniques of rational drug design cannot be applied effectively to these receptors because they are not susceptible to crystallization, at least not in any relevant conformation. Consequently, to the extent structural models of G protein-coupled receptors exist at... Read More
ASPIRE = A sparse precomputed iterative reconstruction environment
1517 – Various medical image modalities including Single-Photon Electron Computed Tomography (SPECT) require image reconstruction. As images have finite sampling and statistical noise, images to accurately represent the information of interest (such as the radioactivity distribution) requires reconstruction via various algorithms. Researchers at the University of Michigan developed ASPIRE... Read More
Methods of Treating Intestinal Disorders
1542 – Post-operative ileus is a common clinical problem for which there is no effective treatment. Following an operation, gastrointestinal motor failure ensues for several days; food and fluids are not tolerated, and no flatus or stool is passed per rectum. Analogues human studies confirm that the colon is slowest to recover. Furthermore, motility patterns do not return entirely to normal as... Read More
pTen,C1-100 plasmids
1519 – pTen,C1-100 plasmids
Isomers of 3-Hydroxymethyl Swainsonine
1314 – Swainsonine is a potent inhibitor of Golgi a-mannosidase II, a late-stage glycoprotein processing enzyme necessary for the incorporation of cancer-associated antigenic carbohydrates. Inhibition of this enzyme prevents the expression of these tumor-associated glycoproteins, resulting in good antitumor and antimetastatic activity without the usual cytotoxic effects of traditional... Read More
Thin-Film, Flat-Panel Dosimeter
1246 – Dosimetry is a measurement and/or calculation of absorbed dose of energy per unit mass of the irradiated target material. In medical applications, the target material is usually the patient, where several modes of diagnostics and therapy rely on ionizing irradiation, including radiotherapy, x-rays, electrons, protons, neutrons, and heavy ions. For example, in radiation therapy for cancer,... Read More
Fractional Moving Blood Volume Estimation with Power Doppler Ultrasound
1216 – In the diagnosis of various medical conditions, it is often useful to examine soft tissues and/or blood flow within the body to show structural details of organs and blood vessels in these organs. Multiple studies have demonstrated increased vascularity (blood flow) in many tumors relative to that of normal tissue, and multiple attempts have been made to depict these differences in... Read More
Monoclonal Antibody UM8D6 Recognizing CD147, a.k.a. Neurothelin
1317 – Hybridoma cells and monoclonal antibody to CD147 - UM8D6
Cell Culture System for Propagation of Kaposi's Sarcoma Associated Virus (HHVS)
1177 – Kaposi’s sarcoma (KS) was originally described in the late 1800’s as a rare and relatively benign neoplasm of elderly men of Jewish or Mediterranean descent. Today, KS is recognized as the most common malignancy in AIDS patients, affecting approximately 20% of human immunodeficiency virus-1 (HIV-1)-positive patients (1-3). AIDS-related KS (also known as epidemic KS) is clinically more... Read More
Augmented Reality Radiation Display System
1677 – Real-time radiation detection is critical in situations where there is danger of exposure to non-background levels of energetic particles and ionizing photos, as well as in the monitoring and demonstration of safe work environments in nuclear power and radioactive waste and materials facilities. University of Michigan researchers have created a high-speed, three-dimensional,... Read More
Methods of Human Prostate Cancer Diagnosis
1068 – Carcinoma of the prostate (PCA) is the second-most frequent cause of death in men in the United States, with increasing mortality in excess of 8% annually. Despite its high prevalence, the underlying molecular mechanisms of genesis and progression of this disease remain poorly understood. Unfortunately, due to the extreme variability in the natural history of this disease, coupled to... Read More
Monoclonal Antibody UM7F8, Specific for the Human Cell Surface Antigen CD98 (4F2)
0949 – Monoclonal antibody UM7F8 specific for the human cell surface antigen CD98 (4F2)
Monoclonal Antibody UMCD6 (Hybridoma 3F1B5), Specific for the T Cell Glycoprotein CD6
0948 – Monoclonal antibody UMCD6 (hybridoma 3F7B5), specific for the T cell glycoprotein CD6
GLEPP1
0872 – The kidney is the organ in vertebrates chiefly responsible for eliminating wastes from the blood and regulating the blood’s chemical balance. The anatomy of the kidney and the architecture of the cells that compose it are related to its function. The glomerulus is the structure in the kidney that filters blood. The major filtration surface of the glomerulus consists of a basement... Read More
Method and Circuit for Remote Teleinteraction
0776 – The ability to effectively teleconference between multiple sites has become a more important aspect of business as the cost of travel has increased. The coordinated use of local/remote pointer functions and local/remote viewpoint control functions in a telecommunications circuit is termed teleinteraction. This invention expands the techniques and technology of teleconferencing... Read More
Melanocortin-3, Melanocortin-4, and Melanocortin-5 Receptors
0853 – Melanocortins, products of pro-opiomelanocortin (POMC) post-translational processing, are known to have a broad array of physiological actions. Nakanishi, S. et al., Nature 278:423-427 (1979). Aside from their well known effects on adrenal cortical functions (adrenocorticotropic hormone, ACTH) and on melanocytes (melanocyte stimulating hormone, MSH), melanocortins have been shown to... Read More
Hybridoma Cell Line 1E7E8, Monoclonal Antibody UMCD2
0323 – Monoclonal antibody 1E7E8 specific for the CD2 molecule
Monoclonal Antibody UM4D4
0238 – Monoclonal antibody UMCD6
Novel Method to Enhance Transmembrane Clearance
4492 – During renal failure, molecules normally cleared by the kidneys are retained in the body, which can result in morbidity and mortality. Dialysis is a commonly used procedure to clear waste products like urea and other solutes via diffusion. In the management of dialysis patients, maximizing solute clearance is a key issue. Urea removal is measured routinely to ensure the delivery of the... Read More
A Distribution of Type I Collagen Morphologies in Bone
4410 – Although many diseases affect bone through changes in mineral and the organic matrix, osteoporosis is the most common bone disease and is a major medical and economic burden facing our society. Each year, an estimated 1.5 million Americans suffer an osteoporotic fracture resulting in direct-care expenditures of 18 billion dollars a year and often leading to a downward spiral in quality of... Read More
JMJD3 Mammalian Expression Vector
4436 – Flag-tagged Jmjd3 gene was cloned into pCDNA.3 vector for expression in mammalian cells.
Barttin Mutation, Gene and Their Uses
2459 – Bartter syndrome is a rare autosomal recessive kidney disease characterized by the kidneys’ inability to reabsorb chloride (salt). Failure to reabsorb chloride leads to excessive salt delivery to the distal tubules of the kidney resulting in excessive salt and water loss from the body. This disease arises on average in 1.2-1.7 cases per 100,000 persons and is caused by mutations in the... Read More
Treatment of Dopamine-Related Diseases (Parkinson’s, Schizophrenia, Depression, Drug Abuse) through Selective Ligands for Dopamine 3 Receptor
4080 – These dopamine 3 (D3) ligands have therapeutic potential for the treatment of dopamine-related diseases like Parkinson’s, depression, drug addiction, schizophrenia, and restless leg syndrome. The D3 agonists are designed to bind selectively to the D3 receptor subtype to partially or fully modulate the receptor, correcting for an excess or deficiency of dopamine. Dopamine is a... Read More
Artificial Matrix Hydrogel Culture Surfaces for Embryos and Embryonic Stem Cells
3175 – This cell culture or Petri dish coating is a water-soluble, fully synthetic hydrogel that provides a stable environment for the growth and sustenance of healthy human embryonic stem cells (hESCs). This stem cell growth matrix can be used for long-term growth of human embryonic stem cells while maintaining all of the cells' known normal functions. The cells maintain their normal genetic... Read More
Type 2 Diabetes, Hyperglycemia and Metabolic Disorders Treatment Counters Insulin Resistance
4705 – The protein Lipocalin-13 regulates insulin sensitivity and glucose metabolism. It counters insulin resistance, making it a promising treatment for hyperglycemia, glucose intolerance, type 2 diabetes, metabolic syndromes, and type 2 diabetes-associated cardiovascular diseases. Diabetes afflicts 346 million people worldwide, according to the World Health Organization. Diabetics number 26... Read More
Micro-Ramp Design Protects Boundary Layer for Efficient Fluid Dynamics in Aircraft Design, Automobile Manufacturing
4350 – This new design of simple micro-ramp technology offers efficiency in airplane flight, automobile performance and more by optimizing fluid dynamic boundary layer control, or the flow of liquid or air across surfaces like airplanes, automobiles and ships, and propulsion systems. The micro-ramps may be mounted on any surface in essentially any application that involves fluid flowing over a... Read More
Heart Sound Challenge: Cardiac Auscultation Training iPhone Application Teaches How to Identify Eight Basic Heart Sounds
5090 – During cardiac auscultation, or listening to the sounds of the heart, it is vital that a physician understand the standard sequence of events in the normal heart to be able to appreciate and make a physical diagnosis from heart sounds. Learning heart sounds through patients can be difficult due to time and auditory constraints. This heart sound application allows physicians, medical... Read More
Gel Electrophoresis Western Blot Immunoassay for FIV, AIDS-HIV, Lyme Disease, Syphilis
4495 – The microscale Western blot uses capillary gel electrophoresis to move a small sample of liquid through a gel-filled tube. It can be used as a diagnostic test to detect and measure the concentration of specific proteins, antibodies or antigens in small samples of blood and other bodily fluids. The microscale Western blot can also be used to purify, characterize, and quantify antigens for... Read More
Biodiesel Synthesis Turns Wet Algae to Energy as Algae Biofuel
4687 – Algae energy could play a major role in achieving energy independence. Since algae grow quickly and naturally all over the world, it could become an almost limitless source of alternative energy, and the most environmentally-friendly product to be converted into biodiesel fuel. The biodiesel synthesis process involves hydrothermal treatment of algae paste followed by filtration and... Read More
Biosensor for Molecular Sensor Devices to Measures Glucose Levels, Potassium Levels, Food Contamination, Nerve Gas
4304 – Biosensors, also called molecular sensors, can detect the presence of specific chemicals, viruses, or molecules in air or liquids. This molecular sensor technology has been tested in devices to monitor glucose levels (as for diabetes), to detect mercury contamination, to monitor potassium levels, to detect melamine contamination, and to sense airborne contaminants such as viruses and nerve... Read More