Joseph Holoshitz
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A Small Molecular Compound for Arthritis and Bone Erosion Treatment
7656 – Unmet Medical Need: Bone damage is a devastating disease outcome for many millions of patients with arthritis or other bone-destroying conditions. Despite the advent of biologic agents, treating erosive bone damage remains a challenging endeavor. Currently used biologic agents and other modern drugs are very expensive, have significant side effects, and most of them can only be... Read More
Treatment of Rheumatoid Arthritis and Other Erosive Bone Conditions with Peptidomimetics
5313 – Rheumatoid arthritis (RA) afflicts approximately 2.5 million people in the US, with over 50,000,000 suffering from the disease globally. There is no cure for RA. Currently available treatments can alleviate some symptoms and modestly slow disease progression; however these therapies fail to provide relief and adequately slow joint damage in all patients. New therapies are needed which... Read More
Potent Backbone Cyclic Peptides Bearing the Shared Epitope Sequence as Rheumatoid Arthritis Drug Lead
5091 – Despite expression of many immunogenic antigens by tumor cells, the immune system often fails to recognize or respond to them, as cancer cells utilize mechanisms that render the immune system tolerant. As such, anti-cancer immunotherapy is being developed treatment strategy to overcome tumor cells evading immune recognition and/or eradication. In this regard, the two main strategies... Read More
Prevention and Treatment of MHC-Associated Diseases
2782 – Rheumatoid Arthritis (RA) and many other autoimmune diseases have been noticed to associate with particular alleles of the MHC (major histocompatibility complex) genes. Due to its chronically progressive and debilitating nature, RA is considered a major public health problem. There are estimated over 50 million individuals afflicted with the disease worldwide. Currently, established... Read More
Therapeutic Modulation of Signal Transduction Aberrations
2070 – Several signaling pathways are involved in a wide range of physiological functions, with increasingly awareness that intercellular and intracellular signal transduction aberrations may underlie the pathogenesis of many diseases. Consequently, attempts to target such signaling abnormalities have become a common theme in the design of new therapeutic strategies. In particular, two... Read More