Nathaniel Szymczak, Ph.D.
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2018-375 – Benzylic methylene linkages are commonly found in many compounds of therapeutic interest but are quickly oxidized by cytochrome P450 enzymes and thus have undesirably short biological half-lives. An attractive approach for improving their metabolic stability is to replace the benzylic methylene linkage with a benzylic difluoromethylene functionality (Ar-CF2-R). These fluorinated... Read More