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7354 – Telomeres are important for protecting the ends of chromosomal DNA as we age. They progressively shorten over time, but this process may undergo abnormal alteration during disease such as cancer. Telomerase is the enzyme complex responsible for extension of telomeres. More specifically, telomerase reverse transcriptase (TERT) is the catalytic portion of this complex responsible for telomere... Read More
7353 – FIZZ1 (found in inflammatory zone) is a cysteine rich secreted protein. It is encoded by a gene known as Retnla or Remα. Upon deletion or overexpression of the gene, researchers have found that it has many roles in the regulation of fibrosis, pulmonary allergic inflammation, immune response, tissue remodeling, wound healing, and infection. However, most of the studies to date have been... Read More
7136 – Alpha smooth muscle actin (α-SMA) is a protein marker of myofibroblast differentiation, which occurs de novo in wound healing, tissue fibrosis and desmoplasia in cancers. While this is a transient event in successful healing, its persistence characterizes chronic fibrosis, which can progress to organ failure. Thus myofibroblast differentiation is an indicator of active fibrosis, which can be... Read More
5877 – No summary available
3132 – UM File # 3132 Background In the United States, 1 in 17 people will develop colon cancer. Colon cancer is the second most frequently diagnosed malignancy as well as the second most common cause of cancer death in the United States. The discovery of specific germ line mutations that predispose to colonic tumor development in man and/or mouse offers the possibility of highlighting and... Read More
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5402 – AMPK is a key enzyme that links cellular metabolism, particularly energy metabolism, with cell division and tumor suppression. This enzyme has received widespread attention in metabolism research and cancer biology. AMPK is considered a therapeutic target in diabetes. AMPK is difficult to study genetically because the enzyme has two catalytic subunits, alpha1 and alpha2 (also known as Prkaa1... Read More
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5635 – This technology is a reversible knockout-mouse model of early onset obesity. These mice are unable to express the proopiomelanocortin gene (Pomc) in hypothalamic neurons (arcPomcKO) but maintain normal pituitary Pomc expression. ArcPomcKO mice are hyperphagic and extremely obese due to central anorexigenic melanocortin deficiency. To study the age of treatment as a determinant of healing... Read More
4556 – This is a research tool available for a materials license or material transfer agreement. CARM1 cDNA was cloned into the pFastBacHTa vector, with bordering EcoRI and HindIII restriction sites for removal, for use in producing baculovirus for protein expression from insect cells.
4553 – Flag and HA tagged EZH2 cloned into pIRES-neo. The EZH2 complex can be purified by either tag purification.
1613 – Murine monoclonal antibody specific for the rat form of the beta2 integrin glycoprotein alpha subunit CD11b
4286 – Ras is a small GTP-binding protein localized to the inner membrane, which controls various cellular processes including growth, death, migration, polarity, and differentiation. Mutations that result in Ras activation are often observed in cancer. RASA1, a member of Ras-regulating protein, Ras GAPs, was shown to play a role in pathophysiology, where an inactive mutation in the human RASA1... Read More
4150 – Genetically modified mouse strains derived from embryonic stem (ES) cells are powerful tools for gene function analysis. ES cells from the C57BL/6 mouse strain are not widely used to generate mouse models despite the advantage of a defined genetic background. Some of the currently used ES Cell lines possess tendency to aneuploidy and consequent inefficiency. Nonetheless, ES cells can be... Read More
4060 – ZNF-148, also known as ZBP-89, is a zinc finger protein, whose folding is stabilized by coordinating zinc ions. ZNF-148 is a widely expressed, four-zinc finger transcription factor that binds to GC-rich DNA elements in a variety of promoters involved in growth regulation. As ZNF-148 is a ubiquitous protein, it targets a number of genes in different tissues. However, research tools with... Read More
4017 – Transgenic rat incorporating Human Diptheria Toxin Receptor gene with podocyte-specific promoter enabling dose-dependent depletion of podocytes. It can be used as a model for studying glomerular diseases such as FSGS.
4015 – Murine monoclonal antibody to rat Glepp1
2991 – Regulators of G-protein signaling (RGS) proteins are important components of signal transduction pathways initiated through G-protein-coupled receptors (GPCRs). The RGS proteins have been proposed as novel drug targets since targeting GPCRs directly is the basis for the development of many therapeutics. Furthermore, evidence is mounting that RGS proteins may play a role in disease states... Read More
2950 – A mouse strain allowing for ligand-regulated activity of beta-catenin in cutaneous keratinocytes (K5/S33Ybeta-catenin-ER)
2948 – Wnt10b and Wnt5a expression vectors
2835 – Transcription factor p53 has been known as a tumor suppressor. It can induce growth arrest and/or apoptosis in cells through activation or repression of downstream target genes. Zinc-finger binding protein-89 (ZBP-89) cooperates with histone acetyltransferas coactivator p300 in the regulation of p21, a cyclin-dependent kinase inhibitor, whose associated gene is a target gene of p53.... Read More
2477 – A transgenic mouse whose genome comprises a heterologous nucleic acid sequence comprising a nucleic acid sequence encoding mouse Wnt10b operably linked to a murine 422/aP2 promoter, wherein the adipose tissue of said transgenic mouse exhibits a higher level of Wnt10b mRNA expression than that of a mouse comprising no heterologous nucleic acid sequence, and wherein said transgenic mouse... Read More
2544 – Phosphopeptides phosphoSH2-B (pY439) and phosphoJAK2 for antibody purposes
2361 – A Human Promoter that Directs Podocyte Specific Transgene Expression
2355 – Homozygous and Heterozygous PEPT2-Deficient Knockout Mice
2186 – Hereditary spastic paraplegia (HSP) is a human neurologic disorder that causes progressive leg weakness and spasticity. There is no treatment to prevent, reverse, or retard this disorder. Mutations in the spastin gene are the most common cause of dominantly inherited HSP. Mouse-model of hereditary spastic parapalegia (spastin gene knock-out mice) University of Michigan... Read More
1862 – This is a research tool available for a materials license or material transfer agreement. Pat5 mouse embryonic stem cells were derived from 129X1/SvJ mouse embryos. Genetic mutations introduced into this cell line by homologous recombination with gene targeting vectors can be passed on through germ cells (sperm) to produce mice with targeted genetic mutations.
1519 – pTen,C1-100 plasmids
1010 – CD28 Knockout Mouse Model
4436 – Flag-tagged Jmjd3 gene was cloned into pCDNA.3 vector for expression in mammalian cells.