Office of Technology Transfer – University of Michigan

Mechanisms of Homeostasis for the Blood Coagulation System: Age/Aging-Regulation of the Factor IX Gene

Technology #1651

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Researchers
Kotoku Kurachi
Managed By
Ed Pagani
Assistant Director, Health Technologies 734-763-3558

Background

Many human disorders are age-related whereby their prevalence and severity increase in aging patients. For example, level of coagulation factor, human factor IX, increases in aging subjects and is potentially involved in cardiovascular disorders. A better understanding of the molecular mechanisms of age-associated diseases is needed.

Technology

Researchers at the University of Michigan have identified age-regulatory sequences and developed a recombinant expression vector that incorporates these sequences in the expression for human factor IX protein. Host cells and non-human transgenic animals containing this expression vector were used to investigate age-dependent expression of human factor IX. These vectors can also be used to determine the age-related regulatory activity of candidate nucleic acid sequences.

Applications and Advantages

Applications

  • Expression vector for understanding age-regulation effect on gene expression.
  • Regulation of factor IX expression in blood clotting disorders such as hemophilia.
  • Understanding of association between human factor IX expression and age-related cardiovascular and thrombotic diseases.
  • Transgenic animals can be used as animal models for age-related diseases.

Advantages

  • Can be applied for regulation of a variety age-related and liver-related disorders gene expression.

Publications:“Genetic mechanisms of age regulation of human blood coagulation factor IX” Science (1999), 285, p. 739.

A patent has been issued for this invention (US 6,610,906)