UM File # 2164p1
Existing cancer screening tests are often invasive, expensive, and lack strong diagnostic utility. For example, prostate cancer is typically diagnosed with a digital rectal exam and/or prostate specific antigen (PSA) screening, which has limited sensitivity and specificity. Thus, development of additional serum and tissue cancer biomarkers is needed to supplement current screening methods.
Researchers at the University of Michigan have identified HIP1 (Huntingtin Interacting Protein 1) as a novel oncogene for prostate cancer, colon cancer, lymphoma and brain cancer, thus providing a potential target for screening in tissue samples. The involvement of HIP1 in the clathrin trafficking pathway can also form the basis for a therapeutic target. Researchers have also created HIP1 antibodies and several cell lines that overexpress HIP1 at varying levels, which can be used for a high-throughput screen for therapeutic compounds that target HIP1.
Applications • Diagnostic kits and screening assays fordevelopment of therapeutic drugs • Therapeutics based on gene therapy,antibody, domain targeting by smallmolecules and anti-sense approaches
Advantages • More sensitive and specific and non-invasivediagnostic and prognostic tests.
“Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells” Cancer Cell (2003), 3, p. 471
See UM File #2164, #2392 and #3667