Office of Technology Transfer – University of Michigan

Small RNA Molecules for the Inhibition of Gene Expression in Cells

Technology #2238

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Researchers
David L. Turner
Managed By
Kristen Wolff
Senior Licensing Specialist, Medical Devices 734-647-5604
Patent Protection
US Patent Pending

Researchers at the University of Michigan Medical School Department of Biological Chemistry have developed a method of inhibiting or reducing the expression of specific genes in mammalian cells, including human cells, by utilizing a method known as RNA interference (RNAi). The method utilizes RNA-based expression cassettes encoding siRNA to inhibit gene expression in mammalian cells. Several novel siRNA compositions are described along with vectors encoding these siRNAs.