Office of Technology Transfer – University of Michigan

Microarray Analysis of Gene Expression in the Aging Human Retina

Technology #2247

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Anand Swaroop
Managed By
Ed Pagani
Associate Director, Health Technologies 734-763-3558


Aging is a universal event in all eukaryotes. In humans, it is associated with progressive and perhaps irreversible impairment of physiological functions, including vision. Age related macular degeneration (AMD) is a major cause of untreatable vision loss in the elderly. The etiology of this disease is dependent upon complex interactions between genetic and environmental risk factors; the two strongest risk factors being age and family history.


University of Michigan researchers have developed gene expression profiles of young and elderly human retinas to identify candidate genes for aging associated retinal diseases.

Applications and Advantages


  • Molecular profiling of retinal gene


  • Rapid identification of candidate genes for aging-associated retinal diseases