Office of Technology Transfer – University of Michigan

Continuous Threshold Voltage Performance in a Discrete Multi-threshold Voltage Process

Technology #2917

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Dennis Sylvester
Managed By
Joohee Kim
Licensing Specialist, Physical Sciences & Engineering 734.764.8202


Genetic tests and assays have an enormous scope of potential applications, ranging from genetic diagnostics of human diseases to detection of pathogens in food products. There are more than 400 diseases that can be diagnosed by molecular biology analysis of nucleic acid sequences. The market for DNA diagnostic devices is growing exponentially as the use of these devices will enable clinicians to quickly and inexpensively detect the presence of a whole array of genetically based diseases.


Researchers at the University of Michigan have developed a simple and highly portable enzyme based electrochemical method to detect DNA produced via PCR and other DNA amplification methods. The system employs a novel electromechanical oligoprobe, PCR reagent mixture, and an enzyme based electrochemical detection system that can be used with a strip for the end-point PCR detection. Use of the novel electromechanical detection technique with inherent enzyme signal amplification eliminates the need for expensive optical detection and the associated equipment, yet allows for DNA detection with fewer amplification cycles. The system can be integrated onto any commercial thermo-cycler such as bench-top or lab-on-a-chip.

Applications and Advantages


  • DNA analysis devices


  • Low cost
  • Handheld device
  • Compact