Office of Technology Transfer – University of Michigan

New Mouse Colon Cancer Progression Model

Technology #3132

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Eric R. Fearon
Managed By
Hui Chen
Licensing and Market Specialist 734-647-7625

UM File # 3132

In the United States, 1 in 17 people will develop colon cancer. Colon cancer is the second most frequently diagnosed malignancy as well as the second most common cause of cancer death in the United States. The discovery of specific germ line mutations that predispose to colonic tumor development in man and/or mouse offers the possibility of highlighting and clarifying genes and mechanisms involved in sporadic tumor development.
Technology Description
This invention describes compositions and methods for generating Cre-lox mice having any gene of interest deleted from their colonic epithelium. This invention further describes the use of this Cre mouse to generate a multitude of colonic gene knockout mice after mating to a floxed mouse containing the floxed-gene of interest. For example, using an Apc floxed mouse, they have demonstrated the utility of this invention by generating a CDX2P-NLS Cre/Apc+/loxP mouse with a strong predisposition toward colon adenocarcinoma.
Applications • This mouse model provides a useful animal screening system for testing new colon cancer drugs.
Advantages • A versatile method that can generate mice having any gene of interest knocked out from their colonic epithelium