Office of Technology Transfer – University of Michigan

Synthetic Niches For Transplanted Cells

Technology #3241

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Researchers
Elliott Hill
Managed By
Kristen Wolff
Senior Licensing Specialist, Medical Devices 734-647-5604
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Publications
Oxidase, superoxide dismutase, and hydrogen peroxide reductase activities of methanobactin from type I and II methanotrophs
J. Inorg. Biochem, Volume 102. Page 1571-1580. 2008
Spectral, kinetic and thermodynamic properties of and Cu(II)-binding by methanobactìn from Methylosinus trichosporium OB3b
Biochemistry, Volume 45. Page 1142-1153. 2006
Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Com), Fe(III), Hg(II), Mn(II), Pb(II), U(VI), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b
J. Inorg. Biochem, Volume 100. Page 2150-2161. 2006

Methanobactin is a small peptide secreted by methane«oxidizing or methanotrophic bacteria and binds to extracellular copper when these bacteria are grown under low copper conditions. Methanobactin is also able to bind to a number of other metals, including gold, iron, nickel, zinc, cobalt, cadmium, mercury, and uranium. ISU researchers and their collaborators investigating the properties of methanobactin have determined that gold in the 3+ oxidation state, Au(III), can be reduced to its zero oxidation state, Au(0) at or below ratios of one Au(III) per methanobactin molecule. Under these conditions, the Au(0) remains associated with the methanobactin, and could serve as a soluble delivery/extraction system for the generation of gold thin films or wires by application to surfaces. Additionally, this methanobactin-Au(III) binding and reduction system may serve as an aurothiolate- type system for the administration of Au(0) for the treatment of rheumatoid arthritis. At ratios of Auml) to methanobactin above one to one, methanobactin binds and catalytically reduces Au(III) to Au(0) with the concomitant production of gold nanoparticles, and this approach can also be used for the formation of gold nanoparticles. Continuous reduction of gold by methanobactin can also be achieved if a reductant is provided. Thus, methanobactin has the potential to replace the use of toxic cyanide for the recovery of gold from ores.

Applications

  • Production of Gold or Copper Nanoparticles
  • Generation of Gold Thin Films or Wires
  • Recovery of Gold from Ores
  • Treatment of Rheumatoid Arthritis

Advantages

  • Versatile (ratio of Au(III) to methanobactin can be varied to produce gold thin films, wires, or nanoparticles)
  • Stable (at ratios of one or fewer Au(III) per methanobactiri, gold remains bound in the Au(0) state, avoiding the toxic effects of gold oxidation of other aurothiolate­type treatments for rheumatoid arthritis)
  • Simple (methanobactin can be purified using a one­step procedure and gold can be recovered by centrifugation)