Office of Technology Transfer – University of Michigan

Multi-Phasic Bioadhesive Nano-Objects as Biofunctional Elements in Drug Delivery Systems

Technology #3452

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Researchers
Joerg Lahann
Managed By
Kristen Wolff
Senior Licensing Specialist, Medical Devices 734-647-5604
Patent Protection
US Patent Pending

Background

Effective drug delivery is important for optimizing efficacy of active ingredients or active agents. Thus, pharmaceutical, nutraceutical, and cosmetic active ingredients/agents, for example, are optimally delivered and maintained near one or more target regions in an organism to expose the target tissue or cells to the desired active ingredients for a predetermined time and concentration. So-called “drug targeting” modifies the pharmacokinetics and biodistribution of active ingredients to provide the potential for increased efficacy, while minimizing intrinsic toxicity.

Technology

Researchers at the University of Michigan have developed nanoparticles and a method of nanoparticle formation for polymer-based multiphasic nano-components (MPNs) for use as active ingredient delivery systems. The MPNs are formed by electrified polymer jetting and include at least one active ingredient. Both phases can contain and release different active ingredients at different rates, thus allowing designed targeted delivery within an organism, while providing controlled release systems or combining incompatible active ingredients. See also UM File 2932.

Applications and Advantages

Applications

  • Drug delivery platform, including coatings
  • Pharmaceuticals and medical diagnostics
  • Bioimaging probes with combined-nl-diagnostic and therapeutic use
  • Cosmetics, including nutritional compositions and fragrance release systems

Advantages

  • Allows combination of incompatible active-nl-ingredients
  • Allows for multiple release rates and kinetics