Office of Technology Transfer – University of Michigan

MScreen - An Integrated Web Enabled High Throughput Screening Cheminformatics System

Technology #3582

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Researchers
Richard Neubig
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Drew Bennett
Associate Director - Software Licensing 734-615-4004

Using High Throughput Screening (HTS) methods in drug discovery and chemistry

High Throughput Screening (HTS) methods are widely used in drug discovery and chemistry where they provide starting points for drug design and understanding the role of a particular biochemical process. These methods allow researchers to effectively perform a large number of biochemical, genetic, or pharmacological tests in a very short period of time. Using HTS researchers are able to identify compounds or genes that are active in certain way and present a development potential for further study or clinical application. HTC testing generates huge amounts of experimental data that must be effectively analyzed and processed.

An Online Tool for High Throughput Screening

Researchers at the University of Michigan have developed a web-based database system for tracking and analyzing high-throughput chemical screening information. The system serves as a laboratory management tool for chemical compounds libraries, facilitates the collection and organization of primary high-throughput screening data, tracks and analyzes follow-up studies including dose-response information, and perhaps most importantly, simplifies the comparison of screening results across different biological targets. In addition it assists users in identifying structurally related compounds from commercial collections for subsequent structure-activity studies.