Office of Technology Transfer – University of Michigan

PDGF Releasing Matrices for Angiogenesis and Tissue Regeneration

Technology #3663

Background

Grafting materials (e.g., autografts, allografts) have been used to repair tissue loss from accidents and diseases. Limited attachment and the risk of pathogen transmission and immune rejection of the materials are however major concerns in grafting procedures. The field of tissue engineering has focused on developing new approaches to develop biological alternatives to harvested tissues and organs to restore, maintain and improve tissue function. Such strategies include the development of scaffolds that are highly porous matrices that enable cell attachment and proliferation and development of 3-dimensional tissue formation.

Technology

Researchers at the University of Michigan have developed three-dimensional porous materials for the delivery of biomolecules such as growth factors. The researchers have achieved a porous matrix that are derived from nano- or micro- spheres for in-vivo release of angiogenic and mitogenic factors. The geometry, growth factor loading capabilities, release profile and biodegradability of these matrices are exciting aspects of this technology. The growth factors loaded in the scaffolds retain their biological activity and these scaffolds have been successful in triggering tissue regeneration and angiogenesis in subcutaneous implantations in animals.

Applications and Advantages

Applications

  • Tissue engineering e.g. tissue regeneration and angiogenesis.

Advantages

  • Controlled and prolonged delivery of biomolecules.
  • Biodegradable.
  • High porosity within structure enables vascularization.

See UM File 3600