Controlled drug delivery is crucial for optimal drug effectiveness in many cases (e.g. for parathyroid hormone (PTH)). Drug formulation is often aimed at optimizing drug availability, but new strategies to develop delivery mechanisms that can control drug release profiles are also being explore.
Researchers at the University of Michigan have developed a pulsatile release device that can be used a delivery system that allows substances to be released in complex pulse patterns. It can deliver drugs, proteins, peptides, growth factors, hormones, DNAs, RNAs, and other biological and non-biological molecules. This biocompatible system can be implanted in humans or animals to deliver therapeutics and other agents. The pulse interval can be tailored to specific needs. Not only can the pulse pattern be varied, but each individual pulse can deliver a specific substance or multiple substances, for customized, optimal release patterns. The researchers have recently demonstrated pulsatile delivery of PTH. For more information, please see: Liu et al., “Pulsatile release of parathyroid hormone from an implantable delivery system,” Biomaterials (2007); 28: p. 4124-31.
Applications and Advantages
- Controlled or pulsatile delivery of biomolecules and drugs.
- Biocompatible and implantable.
- Release profile can be easily customized on an individual basis.
For more information on the composition of the delivery device, please see UM File 3370.