Office of Technology Transfer – University of Michigan

Transgenic Mouse Model for Prostate Specific Expression of EZH2

Technology #3817

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Categories
Researchers
Arul Chinnaiyan
Managed By
Ed Pagani
Assistant Director, Health Technologies 734-763-3558
Publications
The polycomb group protein EZH2 is involved in progression of prostate cancer.
Nature, Volume 419. Page 624. 2002

Background

Prostate cancer is the most common solid tumor in men, with nearly 200,000 new cases and more than 30,000 deaths each year in the Unites States alone. Despite increased understanding of the disease, molecular mechanisms of prostate cancer are not completely elucidated. In this regard, animal models of disease are of significant importance, to evaluate potential therapeutics as well as to understand the underlying pathogenesis.

Technology

Researchers at the University of Michigan have developed a novel transgenic mouse model of human prostate cancer development. These transgenic animals overexpress enhancer of zeste homolog 2 (EZH2), which was found to be overexpressed in hormone-refractory, metastatic prostate cancer. Through gene expression profiling, these researchers have shown that dysregulated expression of EZH2 may be involved in progression of prostate cancer. In this animal model, EZH2 is specifically overexpressed in the mouse prostate using a modified probasin promoter. Unlike conventionally used xenograft prostate cancer mouse models, these EZH2 transgenic mice represent an authentic oncogene-driven model of human prostate cancer development.

Applications and Advantages

Applications

  • Pre-clinical testing of new prostate cancer therapeutics

Advantages

  • Unique oncogene-driven model of human prostate cancer development