Office of Technology Transfer – University of Michigan

Method for Creating Nitric Oxide Surfaces

Technology #4174

Biocompatible Coatings for Cardiovascular Medical Devices This technology increases the biocompatibility for medical devices used in cardiovascular medicine such as artificial heart valves, vascular grafts, and catheters. This coating, which via catalysis generates antithrombotic nitric oxide from endogenous sources, reduces the activation of platelets and therefore reduces the risk of blood clot formation.
Approximately 1 million medical devices are implanted per year in the U.S. as treatments in cardiovascular medicine.1 Implanted devices and temporary devices such as catheters, however, can generate life threatening side effects such as thrombosis and blood clot formation due to adhesion and activation of platelets to the devices.

Locally Generated Nitric Oxide Due to Coating-Mediated Catalysis of Endogenous Molecules Increases Biocompatibility

To reduce the adhesion and activation of platelets to cardiovascular medical devices and, Researchers in the Department of Chemistry have developed a biocompatible coating that locally generates nitric acid from endogenous sources. The locally generated nitric acid inhibits platelet activation and therefore serves as a potent antithrombotic and biocompatible coating. Moreover, the nitric acid is generated by catalytic reactions, and therefore, the coating should retain its biocompatibility for extended periods of time. Consequently, this coating should reduce potentially life threatening side effects due to cardiovascular medical devices and may prove especially useful for implanted devices.

Applications - Biocompatible coatings - Coating-generated nitric oxide from nitrosothiols Advantages - Locally generates nitric oxide to inhibit platelet activation - Reduces the risk of blood clot formation