Office of Technology Transfer – University of Michigan

Blood Storage Bag Modifications to Facilitate Sample Extraction and Unit Subdivision

Technology #4637

Segmented Blood Storage Bags for Blood Product Tests and Extraction of Small Volumes

These blood transfusion bags enable easy extraction of small volumes of the stored blood. The ability to extract small volumes of blood from blood storage bags, while protecting the entire blood product from contamination, is particularly useful for performing quality control tests of blood products and for reducing the standard blood volume used in blood transfusions with infants.

Approximately 80,000 blood components are transfused every day in the U.S. To asses the quality of these blood components blood storage bags typically contain test strips, in which a small fraction (i.e. 0.5 mL) of the blood is isolated from the standard volume of blood (500 mL). This small sample of blood can be used to test for red blood cell integrity, contamination, disease etc. without comprising the remaining volume of blood.

These test strips, however, may have a different quality due to volume-dependent differences in degradation rate. Thus, they are not an accurate proxy for the blood in the storage bag and may even incorrectly suggest a higher quality blood sample than the actual sample being transfused.

Pre-Segmentation of the Blood Storage Bag Enables Easy Extraction of Blood Samples

By creating a blood storage bag with ready-to-separate compartments, small volumes of blood can be extracted from blood storage bags. The blood storage bag has several small-volume compartments that are connected to the main storage volume by ports that are designed break away easily and simultaneously reseal (Figure 1). This system enables rapid extraction of small volumes for blood quality control tests and easy division of original blood volume into smaller volumes for transfusion. Unlike existing products for segmenting a blood volume from the original bag, this blood collection and storage system does not require connecting new tubes, which are time-consuming and increase the risk of contamination. To increase efficiency, ease of use, and reduce potential contamination, this technology incorporates ready-to-separate blood bags with smaller volumes than the original.

Applications and Advantages

Applications

  • Blood product quality control tests
  • Small-volume transfusion applications (i.e. when the patient is an infant)
  • Modification of the standard 0.5 L unit volume

Advantages

  • Reduces wasted blood products
  • Increases efficiency of extracting small volumes of blood from storage bags