Office of Technology Transfer – University of Michigan

Organophosphate Antidotes

Technology #5186

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Researchers
James R. Baker Jr
Managed By
Tiefei Dong
Senior Licensing Specialist, Life Sciences 734-763-5332

Antidotes for Organophosphate Poisoning with Enhanced Efficacy are Needed

Reactive organophosphates (OP) are a class of phosphate-based neurotoxic agents. These compounds cause life threatening symptoms by inhibiting acetylcholinesterase and pose serious threats to both the armed forces and civilian population. Examples of OPs include weaponized nerve agents such as Sarin and VX as well as a number of insecticides commonly used in the agriculture industry. Effective antidotes for OP poisoning are needed for military biodefense applications. Currently available antidotes are effective only for a short window of time after administration due to their rapid clearance from the body. Additionally, there are no clinically approved agents for prophylactic prevention of poisoning by OP.

Controlled-release Antidote for Organophosphate Poisoning with Potential for Prophylactic Administration

Researchers at the University of Michigan have developed a nanoscale platform technology for the sustained release of antidote to poisoning by organophosphate compounds. Utilizing dendrimer technology, this therapeutic has the potential to scavenge OP and reactivate acetylcholinesterase, reversing the symptoms of OP poisoning. The technology provides both enhanced stability in the bloodstream and a novel feedback-release mechanism for antidote, extending the effective period for the antidote. Additionally, this agent may support prophylactic administration, offering protection against OP poisoning in anticipation of exposure.

Applications and Advantages

Applications

  • new therapeutic delivery system for antidote to OP poisoning
  • biodefense applications
  • useful for first-responders in non-military-related OP poisoning cases

Advantages

  • enhances OP scavenging, potentially reducing severity of poisoning
  • increased stability and duration in bloodstream