Office of Technology Transfer – University of Michigan

Personalized non-invasive device to treat tinnitus

Technology #5507

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Researchers
Susan E. Shore
Managed By
Janani Ramaswamy
Patent Protection
US Patent Pending
US Patent Pending
US Patent Pending
US Patent Pending
US Patent Pending

Tinnitus, commonly known as ringing in the ears, affects approximately 50 million people in the U.S. alone, with a particularly high prevalence noted in the aging population. Moreover, tinnitus is the most common disability among U.S. military veterans, for whom estimated associated costs exceed $2 billion annually. In a substantial number of tinnitus cases, symptoms can be severe to debilitating, and there is currently no clinically validated, non-invasive treatment for the condition. Investigators at the University of Michigan discovered that neurons in a brain region responsible for tinnitus initiation are perturbed in a characteristic way during tinnitus (1-3). Treatments based on these findings are under development.  Intellectual Property: U.S. patent 9,242,067 and patent application #14/977,416. Additional patents are pending in Europe, Japan, and Canada. 1 Wu C, Martel DT, Shore SE. Increased Synchrony and Bursting of Dorsal Cochlear Nucleus Fusiform Cells Correlate with Tinnitus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016;36(6):2068-73. doi: 10.1523/JNEUROSCI.3960-15.2016. PubMed PMID: 26865628. 2 Koehler SD, Shore SE. Stimulus timing-dependent plasticity in dorsal cochlear nucleus is altered in tinnitus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(50):19647-56. doi: 10.1523/JNEUROSCI.2788-13.2013. PubMed PMID: 24336728; PubMed Central PMCID: PMC3858633. 3 Dehmel S, Pradhan S, Koehler S, Bledsoe S, Shore S. Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus–possible basis for tinnitus-related hyperactivity? The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(5):1660-71. doi: 10.1523/JNEUROSCI.4608-11.2012. PubMed PMID: 22302808; PubMed Central PMCID: PMC3567464.