Office of Technology Transfer – University of Michigan

Methods for Increasing Transmission Through Scattering Random Media

Technology #5970

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Rajesh R. Nadakuditi
Managed By
Drew Bennett
Associate Director - Software Licensing 734-615-4004
Patent Protection
US Patent Pending

Advances in non-optical medical imaging technology have significantly reduced healthcare costs both through earlier detection of disease and increased precision during medical procedures. Optical imaging of biological tissues is difficult due to the opacity of such tissues in that light cannot be transmitted through the sample. Recent advances in adaptive optics have indicated there is a possibility of imaging such biological tissues through the use of wavefront correction technologies, however, these demonstrations have required that the tissue be characterized before imaging making these techniques infeasible for in vivo imaging. Researchers at the University of Michigan have developed an optical, non-invasive imaging technique that can perform wavefront correction using backscattered light from a light scattering or opaque medium. This technology could lead to the use of optical imaging of human tissue in patients for detecting disease or monitoring progress during surgeries.

Optical Imaging in Biological Tissues

Researchers at the University of Michigan have developed a technique for optical imaging in highly-scattering random media. The technique involves the use of backscattered light from the scattering media to construct an appropriate wavefront which once optimized can be passed through the opaque material to form a coherent image. A complimentary algorithm for wavefront optimization reduces the time to establish the appropriate wavefront when compared to similar methods. This technology could be utilized in highly-scattering media such as biological tissue where optical imaging could improve the ability of healthcare providers to diagnose patients.


  • Optical Medical Imaging
  • Optical Imaging of Biological Tissues


  • Ability to increase transmission using backscattered light
  • Reduction in time to determine optimal wavefront