Office of Technology Transfer – University of Michigan

Rapid MRI with a spectrally tailored signal recovery pulse

Technology #6089

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Hao Sun
Managed By
Janani Ramaswamy
Licensing Specialist, Medical Deviceses 734-763-9081
Patent Protection
US Patent Pending
Strategies for improved 3D small-tip fast recovery imaging.
Magn Reson Med. 2013 Oct 11. doi: 10.1002/mrm.24947., 2013

A rapid incoherent steady state magnetic resonance imaging (MRI) acquisition method has been developed at the University of Michigan. Balanced steady state free precession (bSSFP) acquisition is often used in magnetic resonance imaging (MRI) due to its high signal-to-noise ratio and T2-weighting. However, bSSFP suffers from off-resonance artifacts. The proposed acquisition method offers image characteristics similar to bSSFP, but with reduced off-resonance artifacts.

Design Details

The rapid incoherent steady state MRI acquisition method developed at the University of Michigan uses a spectrally tailored RF pulse in either excitation or signal recovery mode, or both, to introduce T2-weighting and to increase the signal level. The technique also uses an unbalanced gradient after the signal recovery pulse to mitigate off-resonance artifacts. Advantages of the method include ease of implementation and lower sensitivity to motion compared to a spatially tailored pulse. Further, unlike bSSFP, the technique is compatible with magnetization-preparation pulses like fatsat and MT.


  • Steady state T2-weighted imaging with high signal-to-noise ratio and reduced off-resonance artifacts
  • Quantitative (biomarker) imaging of brain tissue parameters for diagnosis of neurodegenerative diseases and monitoring treatment response


  • Ease of implementation
  • Lower sensitivity to motion compared to spatially tailored pulses
  • Compatibility with magnetization-preparation pulses like fatsat and MT