Office of Technology Transfer – University of Michigan

Methods and Apparatus for Optimizing Therapeutic Temperature Control

Technology #6114

Described here are the methods and designed apparatus for optimized therapeutic control for clinical use. Therapeutic hypothermia is now a well-developed technique used in certain surgeries where blood flow to the brain may be jeopardized or in the care of the victim of cardiac arrest. In both settings, this is done to help preserve or improve neurologic function. Hypothermia can be induced by both external and internal means. One of the most widely used techniques is the use of a catheter to cool the blood outside the body which can then flow into the vital organs. Current strategies are very simple devices which only take into account temperature and ignore important biological read-outs making it extremely difficult to provide optimized care for patients. This technology combines multiple end points to improve the effectiveness of this growing therapeutic approach.

A multivariable approach to optimizing therapeutic hypothermia.

Therapeutic hypothermia or protective hypothermia is now a commonly used medical procedure. The basic concept is to induce a colder body temperature in the patient to increase their safety during a complex surgical procedure. Although the exact mechanism as to how the hypothermia enhances patient survival is still debated, the effectiveness of this therapy is driving the development of more advanced devices to adequately modulate body temperature. Current methods are relatively simple catheter systems which cool the blood using a temperature feedback sensor and computer controller. A more advanced system developed at The University of Michigan uses multiple sensors which monitor many biological read outs ignored by current technologies can provide much more accurate and effective patient care.


  • Post resuscitation management of cardiac arrest patient
  • Management of stroke and traumatic brain injury
  • Management of multisystem trauma patient
  • Management of sepsis
  • Management of complex surgical patient


  • Personalized and physiologically driven
  • Automated
  • Simultaneous metabolic and physiologic resuscitation