Office of Technology Transfer – University of Michigan

Fiber optic Raman spectroscopy probe with hollow insertion system

Technology #6392

Fiber optic Raman fluorescence reflectance spectroscopy probe Calciphylaxis is a painful and debilitating condition that creates large open wounds most frequently in patients with renal failure. Calciphylactic lesions are characterized by the precipitation of calcium deposits in the skin and soft tissues, which results in vessel thrombosis and tissue necrosis. Diagnosis of calciphylaxis typically occurs through histologic evaluation of biopsy specimens, but incisional biopsy of the affected site can result in further local inflammation and lead to a cycle of additional calcium deposition. There is great interest in developing a non-invasive diagnostic method that can identify calciphylaxis lesions and therefore avoid creating local inflammatory trauma.

Fiber optic Raman spectroscopy probe with hollow insertion system

The proposed technology consists of a fiber optic probe arranged around the circumference of a hollow cylinder, which allows for materials to either be delivered or removed from regions collocated with area of spectroscopic observation. Co-localization can occur on the surface, near the surface, or within subsurface regions depending on the layout of the optical fiber. The hollow device can also serve as a guide for the insertion of instruments after spectroscopic examination. The proposed technology has successfully differentiated between calciphylaxis and normal surrounding tissue based on the physical characteristics of the tissue. Peaks in the Raman spectroscopy that correlate with phosphate minerals were observed in calciphylaxis tissue that had large areas of calcification.


  • Tissue Evaluation
  • Examine wound healing
  • Determine tissue constituents
  • Monitor thrombosis
  • Assess tissue growth
  • Observe tissue deterioration


  • Co-localize tissue analysis with tissue removal
  • Co-localize tissue analysis with therapeutic delivery
  • Combine tissue analysis with instrumentation guidance