Office of Technology Transfer – University of Michigan

Renal Risk Index Calculator

Technology #6460

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Pratima Sharma
Managed By
Drew Bennett
Associate Director - Software Licensing 734-615-4004
Patient-Specific Prediction of ESRD after Liver Transplantation
J Am Soc Nephrol 24. (JASN), 2013

The Renal Risk Index (RRI) uses patient qualities after transplant to predict the possibility of End-Stage Renal Failure (ESRD) in patients. ESRD affects 339 people per million, and can be caused by poor recipient response to liver transplantation. However, predicting which patients are most at risk for ESRD after liver transplantation is a difficult task. The RRI is a powerful measure of risk for ESRD, allowing physicians and patients to make the best informed decisions possible.

Early Prediction of Transplant Complications

A total of 43,514 post-liver-transplantation subjects were retrospectively studied for the relationships between patient qualities and ESRD development. Fourteen factors were found to contribute to patient risk for ESRD. With over $32 billion in insurance spending on ESRD treatments each year and the development of innovative treatments such as regeneration of renal tissues and implantable kidneys, a tool to predict risk of ESRD can help doctors and patients consider all options and identify those most likely to increase patient outcomes.


  • Early prediction of ESRD.
  • Allows patients and physicians to focus on changing patient qualities which will most greatly reduce ESRD risk.


  • The only tool of its kind available.