Acinetobacter baumannii are opportunistic pathogens that are frequently associated with hospital acquired infections. Multi-drug resistant strains are not uncommon and even pan-resistant strains have been identified. This antibiotic resistance appears to be mediated through the formation of biofilms. Biofilms are formed through a highly structured extracellular polymeric matrix which allows the bacteria to group together on a surface. When A. baumannii lose the ability to form biofilms, they become susceptible towards antimicrobial agents.
Identification of Novel Biofilm Inhibitors
To identify inhibitors of A. baumannii biofilm formation, high-throughput screening was performed using a library of marine microbial derived natural product extracts. This lead to the identification of a metabolite, cahuitamycins, derived from Streptomyces gandocaensis. This class of compounds was demonstrated to inhibit biofilm formation in several in vitro assays.
- Therapeutic for Acinetobacter baumannii infections
- Antimicrobial agent for medical device sterilization
- There is a critical need to generate novel antimicrobial agents
- May be used in combination with existing antibiotics for improved efficacy