Center for Disease Control (CDC) has declared that one of the biggest public health concerns that we currently face is a gram-negative bacterium. These bacterium cause many diseases and are inherently hard to treat. In addition, these bacterium also adapt quickly and become resistant to most of the available antibacterial/ antibiotic drugs. In urinary tract infections (UTIs), E. coli is often the main causative gram-negative bacteria. UTIs result in 7-10 million doctor visits a year and can cost up to $1.6 billion in direct and indirect medical costs annually. To date, the primary treatment for a UTI is antibiotics. There is currently a need for more antibacterial/ antibiotic drugs to combat this and other gram-negative related diseases.
Novel inhibitor of gram-negative bacteria
During a screen of over 33,000 marine microbial derived natural products, a novel family of antibacterial compounds was found to inhibit growth of a wild type uropathogenic E. coli by over 90%. Additionally, these compounds require components found in pathogenic bacteria but not commensal bacteria, suggesting they will not cause harm to “good” bacteria. These novel compounds could provide a new treatment option for UTIs as well as other gram-negative bacteria related illnesses.
- New antibacterial compound
- Treatment of UTIs
- Possible treatment of other gram-negative bacterial diseases
- Natural compound
- Doesn’t hurt commensal bacteria
- Targeted towards gram-negative bacteria