Office of Technology Transfer – University of Michigan

MSFragger - Ultrafast and Comprehensive Identification of Peptides from Tandem Mass Spectra

Technology #7143

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7143 - MSFragger - 60 Day Evaluation Use License
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7143 - MSFragger - Academic and Research Education Use License
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Managed By
Drew Bennett
Associate Director - Software Licensing 734-615-4004

The advent of tandem mass spectrometry (MS/MS) also known as shotgun proteomics has enabled the identification of large numbers of proteins in a biological sample and had become an indispensable tool for academic researchers as well as pharmaceutical and molecular diagnostic companies around the world. Currently, the field of tandem mass spectroscopy represents the biggest share (36%) of the mass spectroscopy market. However, the analysis of large amount data produced by proteomics experiments in addition to the advances in speed of modern instrument and growing interest in protein-drug, protein-protein interaction as well a post-translation modification has produced a significant challenge. While computer clusters are an option to provide additional processing power, but due to their expense, difficulty to maintain, and limited lifespan, there is a need for alternative methods to combat this problem.

Applications
* Peptide identification from MS/MS data
* Protein-drug interaction in high throughput screening
* Protein-protein interaction in cellular pathways
* Biomarker analysis from patient’s blood samples

Advantages
* Reduces computational cost, turnaround time for proteomic analysis and false positives
* Provides cluster level performance on personal workstation and can consider all post-translation modifications