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5052 – Electrical interfaces to biological tissue, whether to read out biological signals, to artificially stimulate nerves or muscles, or to deliver drugs is a long persecuted field of high interest. Many modern probes consist of a needle like shank hosting sites for recording or stimulation. The sites can be electrodes, openings of optical waveguides, chemical sensors, out- and inlets of fluid... Read More
5051 – Producing quantities of semiconductors with high purity on the industrial scale is usually an expensive endeavor, due to the labor and energy-intensive processes required for annealing. Electroreduction is a promising method but has proven difficult to achieve continuously. Previously, vapor-liquid-solid and liquid-liquid-solid methods have been successfully used to synthesize... Read More
Microporous Coordination Copolymer Built from Benzene-1,4-Dicarboxylate and Naphthalene-2,6-Dicarboxylate
5043 – Porous coordination polymers have been in existence since the late 1990s. They are commonly used in commercial applications such as heterogenous catalysis, separation processes, and gas storage. They can be custom-made to order with various types of inorganic and organic linkers and ligands. However, few materials to-date have a porous Brunauer-Emmer-Teller (BET) surface area over 4000... Read More
4980 – Hot-wire anemometers are used to measure turbulent flow variables such as mean and fluctuating velocity components and temperature. Hot-wire anemometry is based on heat transfer through forced convection from a heated wire. The amount of heat transfer caused by an incident flow to maintain the hot-wire at a constant temperature is proportional to the velocity of the fluid. If the fluid... Read More
4976 – A dual particle imaging system for special nuclear materials (SNMs) detection in high-background radiation environments has been developed. This system is capable of imaging both fast neutrons and γ-radiation with tunable efficiency and angular resolution. The threat of nuclear arms and radioactive warfare techniques necessitates efficient and reliable radiation detection to help ensure... Read More
4958 – Breast cancer is a disease that exhibits a wide range of molecular deviations and clinical outcomes. In 2009, approximately 250,000 women in the U.S. were diagnosed with breast cancer and over 40,000 women died from the disease. A number of recurrent gene fusions and translocations, which is the formation of a gene from the association of two separate genes, have been linked to the... Read More
4957 – This is a research tool available for a materials license or material transfer agreement. Murine skin fibroblasts homozygous for the lymphoproliferation spontaneous mutation (Faslpr) have been isolated and stably transfected with either an empty GFP-tagged vector (Control Faslpr, GFP-Faslpr) or a vector overexpressing Fas (GFP-Fas-Faslpr).
4956 – This is a research tool available for a materials license or material transfer agreement. Researchers have developed an oral squamous cell carcinoma (OSCC) cell line that has stably suppressed levels of CD44 (UMSCC14A) and its vector control.
4955 – This is a research tool available for a materials license or material transfer agreement. Researchers have developed an oral squamous cell carcinoma (OSCC) cell line with stably suppressed levels of CD44 (UMSCC14A) that is anoikis-resistant. These clonally derived cells were generated by growth under susptension culture confitions and then clonally isolated by limiting dilution.
4954 – This is a research tool available for a materials license or material transfer agreement. Oral squamous cell carcinoma (OSCC) cell lines with stably suppressed levels of SIRT3 (UMSCC1, UMSCC14A, UMSCC17B) have been developed, along with their vector control counterparts.
4953 – This is a research tool available for a materials license or material transfer agreement. The HSC-3 oral squamouse cell carcinoma (OSCC) cell line has been stably suppressed in its expression of RIP, as well as stably transfected with the control vector.
5080 – Tissue microarray (TMA) is a recent innovation in the field of pathology. A TMA may contain many representative tissue samples from hundreds of different cases assembled in a single paraffin block, facilitating high throughput analysis of multiple specimens at the same time. Using this technique, up to 1000 or more tissue samples can be assayed on a single slide. It can permit... Read More
4936 – In 2007 there were over 37 million scans using Computed Tomography (CT) equipment in the US alone. The number of scans and the use of CT equipment continue to grow as CT technology allows clinicians to better diagnose and treat patients. By using images produced by CT scans, doctors can visualize the internal organs of patients noninvasively. CT simulation is a process used by a radiation... Read More
4974 – Blaise® is a questionnaire tool (software) developed by Statistics Netherlands and used by statistical agencies and large data collection organizations worldwide. Michigan’s CTT (described below) is possibly one of the the only tools that can help users more easily test instruments being contructed in Blaise, making it extremely useful to the Blaise user community. (Blaise is a registered... Read More
4975 – Blaise® is a questionnaire tool (software) developed by Statistics Netherlands and used by statistical agencies and large data collection organizations worldwide. MQDS is possibly one of the the only products that can easily create the specific documentation (for example questionnaire documentation, codebooks, etc.) from Blaise, making it extremely useful to the Blaise user community.... Read More
4931 – Diabetes affects approximately 16 million people in the United States, of which 25% have diabetes-related microvascular complications, such as diabetic retinopathy. Diabetic retinopathy is a diabetic eye disease caused by damage to the small blood vessels of the retina in the back of the eye. The small vessels can be damaged by high blood glucose and high blood pressure, causing them to... Read More
4917 – Millimeter wave (MMW) frequencies are becoming increasingly lucrative due to potential applications in areas such as remote sensing, wireless communication, imaging, atmospheric studies, autonomous vehicle control, and perimeter security. Whereas MMW wavelengths are short enough to allow the fabrication of compact, high-resolution radars compatible with monolithic microwave integrated... Read More
4919 – Infections from mosquito-borne neurotropic alphaviruses, such as western equine encephalitis virus (WEEV) and Venezuelan equine encephalitis virus (VEEV), can lead to serious illness. Eastern equine encephalitis (EEE) caused by the EEE virus, another neurotropic alphavirus, is considered to be one of the most severe mosquito-borne diseases in the United States with a mortality rate of... Read More
4889 – There are approximately 1.7 million people in the U.S living with limb loss. With 6% of them being upper extremity amputees. Most of these amputees are fitted with prosthetics ranging from basic hook systems, to electrically operated robotic arms. The more sophisticated prosthetics have evolved to be capable of sensing motor muscle signals, allowing the user to have functionality of motor... Read More
4866 – When a patient’s medical condition necessitates the surgical replacement of the hip joint with an artificial prosthesis (reconstructive hip arthroplasty), pre-operative planning is vital in preparation. Part of that process is the production of a template for the replacement. The traditional method for templating requires the use of printed radiographs and measurements made using... Read More
4856 – Patchy particles have multiple functions A method has been devised to engineer particles with magnetically activated surfaces. Researchers have demonstrated that it is possible to use a magnetic field to induce a change in color on a display made with these particles. Patchy poly(lactide-co-glycolide) particles are prepared such that one side of the particle is magnetic and dyed... Read More
4846 – Neurodegenerative disorders associated with the protein tau, which is abundantly expressed in neuronal cells, are referred to as tauopathies. The most common tauopathy is Alzheimer’s disease. In Alzheimer’s disease, two kinds of abnormal protein aggregates, plaques and tangles, are thought to be responsible for damaging and killing nerve cells. Tangles are created by excessive tau... Read More
4843 – The terahertz (THz) region of the electromagnetic spectrum (1012 Hz), between infrared- and micro- waves, has the potential to enhance homeland security, medical imaging, pharmaceutical analysis, chemical/biological detection, semiconductor monitoring, and quality control surveillance for a multitude of industries. Unfortunately, THz radiation sources have traditionally been cumbersome... Read More
4801 – The incidence of the metabolic disorders of diabetes and obesity has reached epidemic levels. The IDF (International Diabetes Federation) reports that 552 million people may have diabetes by 2030 and the disease will strike one in 10 adults by that time. China has more affected individuals than any other, with 90 million diabetics and more than ten million Americans are diagnosed with... Read More
4778 – Optofluidic lasers bring together nanophotonics and microfluidics and have been envisioned as sensitive biological and chemical sensors. Currently, they are limited by the laser wavelength, which must match that of the absorption wavelength of the dyes used. Energy transfer optofluidic lasers are far more efficient, but only a handful of them have been successfully demonstrated thus far.... Read More
4771 – This is a research tool available for a materials license or material transfer agreement. Enhanced green fluorescent protein (EGFP) inserted into the Pax2 gene locus such that EGFP is expressed whenever the Pax2 gene is transcribed. The EGFP insertion does not disturb the Pax2 protein, nor create a mutation in the endogenous Pax2 locus. EGFP mouse and embryonic stem cells used to... Read More
4768 – The Michigan Institute for Clinical & Health Research (MICHR) at the University of Michigan has developed an interactive training to engage and prepare community partners to both interact with Institutional Review Boards (IRB) and to perform ethical research practices in their community settings. There are already many hurdles for research that respectfully engages with communities,... Read More
4762 – This technology enables the targeted ablation of specific cell types in ablation therapies such as in the treatment of cardiac arrhythmias. The technique, by specifically destroying certain cell types, reduces the time of the ablation therapies and increases their effectiveness. Approximately 2.2 million individuals in the U.S. suffer from atrial fibrillation, the most common cause of... Read More
4754 – Single and few-layer graphene are promising materials for post-silicon electronics, owing to their potential of integrating bottom-up nanomaterial synthesis with top-down lithographic fabrication. However, as single-layer graphenes are intrinsically semi-metals, introducing energy bandgap to these materials requires patterning nanometer-width graphene ribbons or utilizing special... Read More
4753 – NMR Spectroscopy is a key method to determine the structures, interactions and dynamics of proteins in solution. A key step in all of these applications is the assignment of individual NMR signals to individual nuclei of the protein. Obtaining these assignments with any level of confidence has always been extremely labor intensive, and required a high-level of expertise. ... Read More
4743 – The peripheral nervous system includes nerve roots, the brachial and lumbosacral plexuses, and peripheral nerves. Focal lesions of any of these structures will result in a specific pattern of weakness or sensory loss that can be used to accurately localize the lesion. The anatomy is complicated, however, with many lesions presenting with overlapping deficits. Nerve Whiz is an... Read More
4737 – Mutations, amplifications or miss regulations of epidermal growth factor receptor (EGFR) or family members are implicated in about 30% of all epithelial cancers. Several therapeutic interventions, including small molecules and antibodies, have been developed that target EGFRs, including gefitinib, erlotinib, and cetuximab. However, many patients develop resistance to EGFR inhibitors,... Read More
4730 – Currently, there is a lack of text/network mining software available to the typical analyst end-user. Generally available text mining algorithms require extensive programming to implement. Typically, these more complex algorithms have an extremely steep learning curve, requiring a long-term commitment of professional software developer resources. Such solutions usually cannot be... Read More
4706 – Human and other mammalian stem cells including embryonic stem cells (hESCs and ESCs) have enormous potential as predictive models of early development or for cell replacement therapies. Because hESCs show remarkable sensitivity towards environmental influences, their continuous undifferentiated growth has been a major challenge undermining widespread use of hESCs in many applications.... Read More
4699 – Protein ubiquitination is a precisely controlled process mediating cell cycle timing, protein destruction, and signal transduction. Evidence suggests that cellular transformation deregulates or modifies components of the Ub system and its essential ubiquitin pathway enzymes. However, inhibition of deubiquitinases (enzymes that release Ub from target proteins, DUBs) may have anti-tumor... Read More
4682 – Despite the development of more than 25 approved anti-HIV drugs and improvements in their availability, the rate of new HIV-1 infections is outpacing the rate of new individuals receiving antiretroviral therapy. At present, it appears that an efficacious HIV vaccine is still many years away. Therefore, other methods for halting the spread of HIV are vitally needed. Some of the most... Read More
4650 – Phased arrays have been widely employed in the military radar applications for several decades. Recent growth in civilian radar-based sensors and communication circuits has drawn an increasing interest in the use of the phased array technology in commercial arena. For instance, phased arrays can be utilized in wireless networks, vehicular-radar based sensors, as well as emerging... Read More
4646 – ET743 (Trabectedin) is a tetrahydroisoquinoline natural product with potent activity as a chemotherapeutic originally isolated from the tunicate Ecteinascidia turbinata. This drug has been commercialized in Europe for patients with soft tissue sarcoma, and is in clinical trials in the US. This drug has been found to have unique mechanisms of action that are beneficial with regard to its... Read More
4637 – These blood transfusion bags enable easy extraction of small volumes of the stored blood. The ability to extract small volumes of blood from blood storage bags, while protecting the entire blood product from contamination, is particularly useful for performing quality control tests of blood products and for reducing the standard blood volume used in blood transfusions with infants. ... Read More
4636 – Gallium phosphide (GaP) has a mid-sized optoelectronic bandgap well suited for solar-powered water electrolysis. One key deficiency of GaP and GaP-based alloys is their susceptibility to interfacial degradation/oxidation. High quality, protective native/thermal oxides are not tenable on Ga-based III-V semiconductors and presently there are few available chemical routes for protecting GaP... Read More
4630 – Cardiovascular disease is still the leading cause of mortality in the United States, with 1 million lives lost each year. Cardiovascular patients could benefit by using tissue-engineered living blood vessels as a better source of grafts. Scaffolds play a pivotal role in this tissue engineering but the structural design must consider biocompatibility and biodegradability of the polymers,... Read More
4627 – Methanotrophs, organisms that consume methane as their sole source of carbon and energy, are found in a wide variety of environments where methane/ air interfaces develop, including forest and agricultural soils, wetlands, landfills, geothermal areas, among other locations. Most of these bacteria are obligate methanotrophs, i.e. can only grow on C1 substrates, although Methylocella spp.... Read More
4605 – Quantitative methods of microscopic imaging, particularly in dynamic living systems, are increasingly “in-demand” by researchers. One such method, FRET (fluorescence resonance energy transfer), measures the timing and location of intermolecular interactions in living cells. However, to-date, commercially available methods measure FRET in arbitrary units, cannot discriminate FRET... Read More
4594 – Constipation is one of the most commonly encountered gastrointestinal complaints in clinical practice – a recent review reported the prevalence of North American chronic constipation at 10-15%. Constipation is a symptom-based disorder of heterogeneous pathophysiology and management guidelines have universally recommended that patients with typical constipation related complaints and no... Read More
4583 – In behavioral neuroscience research involving sleep, there is a need for automated state scoring to correctly identify how the experimental manipulations impact the state of the animal, including humans. Manual state scoring of physiological recordings in sleep studies is time-consuming, resulting in a data backlog, research delays and increased personnel costs. Researchers at... Read More
4582 – UM File # 4582 Background In behavioral neuroscience research involving sleep, there is a need for automated state scoring to correctly identify how the experimental manipulations impact the state of the animal, including humans. Manual state scoring of physiological recordings in sleep studies is time-consuming, resulting in a data backlog, research delays and increased personnel costs. ... Read More
4581 – Cost effective and highly efficient renewable energy is becoming ever more important due to the rising energy prices and the serious issue of global warming from burning fossil fuels. Solar energy is a non-exhaustible and green energy. Solar cells are being developed as a promising solution to the energy crisis and environmental pollution. Third-generation organic solar cells offer a... Read More
4576 – Mammography is the most cost-effective screening method for early detection of breast cancer; however, mammographic sensitivity is often limited by the presence of overlapping dense fibroglandular tissue in the breast. Breast cancer digital tomosynthesis mammography (DTM) is a new modality in which a series of projection view (PV) mammograms of the breast is acquired as the x-ray source... Read More
4556 – This is a research tool available for a materials license or material transfer agreement. CARM1 cDNA was cloned into the pFastBacHTa vector, with bordering EcoRI and HindIII restriction sites for removal, for use in producing baculovirus for protein expression from insect cells.
4553 – Flag and HA tagged EZH2 cloned into pIRES-neo. The EZH2 complex can be purified by either tag purification.